Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Melvin E. Andersen"'
Autor:
Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of
Externí odkaz:
https://doaj.org/article/06e7c45c8815464bb61eca7e8d431b5c
Autor:
Chantel I. Nicolas, Matthew W. Linakis, Melyssa S. Minto, Kamel Mansouri, Rebecca A. Clewell, Miyoung Yoon, John F. Wambaugh, Grace Patlewicz, Patrick D. McMullen, Melvin E. Andersen, Harvey J. Clewell III
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Current computational technologies hold promise for prioritizing the testing of the thousands of chemicals in commerce. Here, a case study is presented demonstrating comparative risk-prioritization approaches based on the ratio of surrogate hazard an
Externí odkaz:
https://doaj.org/article/c77f706ac85c49c3bc5d018511b024a1
Autor:
Michael B. Black, Melvin E. Andersen, Salil N. Pendse, Susan J. Borghoff, Michael Streicker, Patrick D. McMullen
Publikováno v:
Data in Brief, Vol 38, Iss , Pp 107420- (2021)
The National Toxicology Program (NTP) reported that chronic exposure to varying dietary concentrations of 4-methylimidazole (4-MeI) increased lung tumors in female and male mice [1]. In this study, mice (male and female B6C3F1 mice) were either admin
Externí odkaz:
https://doaj.org/article/14f8cca609cc494895eaded385e8c96a
Autor:
Lu Li, Jingqi Fu, Dan Liu, Jing Sun, Yongyong Hou, Chengjie Chen, Junbo Shao, Linlin Wang, Xin Wang, Rui Zhao, Huihui Wang, Melvin E. Andersen, Qiang Zhang, Yuanyuan Xu, Jingbo Pi
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Non-alcoholic fatty liver disease (NAFLD) is an emerging global disease with increasing prevalence. However, the mechanism of NAFLD development is not fully understood. To elucidate the cell-specific role of nuclear factor erythroid-derived 2-like 2
Externí odkaz:
https://doaj.org/article/2a2fcbeed5644329b70ad1aa8cb5b568
Autor:
Peng Xue, Yongyong Hou, Zhuo Zuo, Zhendi Wang, Suping Ren, Jian Dong, Jingqi Fu, Huihui Wang, Melvin E. Andersen, Qiang Zhang, Yuanyuan Xu, Jingbo Pi
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Nuclear factor erythroid 2-related factor 1 (NRF1), a ubiquitously expressed CNC-bZIP transcription factor, plays a critical role in white adipocyte (WAC) biology, whereas the underlying mechanisms remain unknown. The mouse Nrf1 gene is transcribed i
Externí odkaz:
https://doaj.org/article/a812b2ba731142918a5e1c80f17005f1
Autor:
Saad Haider, Michael B. Black, Bethany B. Parks, Briana Foley, Barbara A. Wetmore, Melvin E. Andersen, Rebecca A. Clewell, Kamel Mansouri, Patrick D. McMullen
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Efficient high-throughput transcriptomics (HTT) tools promise inexpensive, rapid assessment of possible biological consequences of human and environmental exposures to tens of thousands of chemicals in commerce. HTT systems have used relatively small
Externí odkaz:
https://doaj.org/article/b8192d7fd04c4982a628c821724c6ce5
Autor:
Rehana K. Leak, Edward J. Calabrese, Walter J. Kozumbo, Jeffrey M. Gidday, Thomas E. Johnson, James R. Mitchell, C. Keith Ozaki, Reinhard Wetzker, Aalt Bast, Regina G. Belz, Hans E. Bøtker, Sebastian Koch, Mark P. Mattson, Roger P. Simon, Randy L. Jirtle, Melvin E. Andersen
Publikováno v:
Dose-Response, Vol 16 (2018)
Human performance, endurance, and resilience have biological limits that are genetically and epigenetically predetermined but perhaps not yet optimized. There are few systematic, rigorous studies on how to raise these limits and reach the true maxima
Externí odkaz:
https://doaj.org/article/3eb871b58f0547168e8f9fcf6a6ec730
Autor:
Jenny M Pedersen, Yoo-Sik Shim, Vaibhav Hans, Martin Blake Phillips, Jeffrey M. Macdonald, Glenn Walker, Melvin E. Andersen, Harvey J. Clewell, Miyoung Yoon
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 4 (2016)
Accurate prediction of metabolism is a significant outstanding challenge in toxicology. The best predictions are based on experimental data from in vitro systems using primary hepatocytes. The predictivity of the primary hepatocyte-based culture syst
Externí odkaz:
https://doaj.org/article/88ed7d6f48f94a27a7855aeae14a7820
Publikováno v:
Open Biology, Vol 3, Iss 4 (2013)
Multi-component signal transduction pathways and gene regulatory circuits underpin integrated cellular responses to perturbations. A recurring set of network motifs serve as the basic building blocks of these molecular signalling networks. This revie
Externí odkaz:
https://doaj.org/article/37cf9f280580411088edb7994ab810f6
Autor:
Sudin eBhattacharya, Lisl K.M. Shoda, Qiang eZhang, Courtney eWoods, Brett A. Howell, Scott Q. Siler, Jeffrey L. Woodhead, Yuching eYang, Patrick eMcMullen, Paul B. Watkins, Melvin E. Andersen
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
We provide an overview of computational systems biology approaches as applied to the study of chemical- and drug-induced toxicity. The concept of ‘toxicity pathways’ is described in the context of the 2007 US National Academies of Science report,
Externí odkaz:
https://doaj.org/article/578b7eda103f4784bce6ab2aa88a0665