Výsledky vyhledávání - "Melvin D. Trousdale"

Autoimmune Dacryoadenitis and Sialadenitis Induced in Rabbits by Intravenous Injection of Autologous Lymphocytes Activated Ex Vivo Against Lacrimal Antigens

Autor: Melvin D. Trousdale, Austin K. Mircheff, Padmaja B. Thomas, Rui Hua Wei, Joel E. Schechter, D. M. Samant

Publikováno v: Cornea. 31:693-701

PURPOSE Autologous peripheral blood lymphocytes, activated in a mixed cell reaction when cocultured with purified rabbit lacrimal epithelial cells, are known to induce a severe autoimmune dacryoadenitis when injected directly into the donor animal's

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96dbb4ce6524e49a37ba8730dee39c7f
https://doi.org/10.1097/ico.0b013e31823f8e47

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Distinct Dacryoadenitides Autoadoptively Transferred to Rabbits by Different Subpopulations of Lymphocytes Activated Ex vivo

Autor: D. M. Samant, Melvin D. Trousdale, Douglas Stevenson, Joel E. Schechter, Shivaram Selvam, John D Gray, Yanru Wang, Austin K. Mircheff, Padmaja B. Thomas

Publikováno v: Cornea. 29:1153-1162

PURPOSE To test whether CD4+ T cells proliferate in mixed cell reactions with autologous lacrimal gland (LG) acinar cells and whether these cells can autoadoptively transfer disease. METHODS Purified acinar cells were gamma irradiated and cocultured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2659f4965c70d436624923e7ec47f2ad
https://doi.org/10.1097/ico.0b013e3181d0090e

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Suppression of Lymphocyte Proliferation and Regulation of Dendritic Cell Phenotype by Soluble Mediators from Rat Lacrimal Epithelial Cells

Autor: Yanru Wang, M. De Saint Jean, Austin K. Mircheff, Joel E. Schechter, Melvin D. Trousdale, T. Nakamura

Publikováno v: Scandinavian Journal of Immunology. 70:53-62

Lacrimal epithelial cells appear to constitutively secrete autoantigens to their underling stroma. The present experiments address the hypothesis that they also secrete soluble factors that regulate immune responses. Epithelial cells, spleen cells an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0df4683c622fac238c59cb09e192717
https://doi.org/10.1111/j.1365-3083.2009.02272.x

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Long-Term Topical Cyclosporine Treatment Improves Tear Production and Reduces Keratoconjunctivitis in Rabbits With Induced Autoimmune Dacryoadenitis

Autor: D. M. Samant, Padmaja B. Thomas, Z. Zhu, Melvin D. Trousdale, Sang W. Song, Shivaram Selvam, Douglas Stevenson, Yanru Wang, Austin K. Mircheff, Joel E. Schechter, Samuel C. Yiu

Publikováno v: Journal of Ocular Pharmacology and Therapeutics. 25:285-291

To use a rabbit model of induced autoimmune dacryoadenitis to evaluate the efficacy of topical ophthalmic cyclosporine A (CsA).Autoimmune dacryoadenitis was induced by injecting autologous peripheral blood lymphocytes, which had been activated in a m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cbdd3f7ed05f3f279b0cd7a3b2c190
https://doi.org/10.1089/jop.2008.0138

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In vitro and in vivo studies with sodium hyaluronate as a carrier for intraocular gentamicin

Autor: Melvin D. Trousdale, Carlos A. Moreira Jr., Roger W. Jelliffe, Deborah K. Armstrong, Peter E. Liggett, Ana Tereza Ramos Moreira, Coreen C. Woodford

Publikováno v: Acta Ophthalmologica. 69:50-56

We compared the in vitro growth of common intraocular pathogens Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa in rabbit vitreous and in sodium hyaluronate (SH) with and without gentamicin. The minimal inhibitory concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6fd0a5365125a37e8e285ad572bedd
https://doi.org/10.1111/j.1755-3768.1991.tb01990.x

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Autoimmune dacryoadenitis and keratoconjunctivitis induced in rabbits by subcutaneous injection of autologous lymphocytes activated ex vivo against lacrimal antigens

Autor: Shivaram Selvam, S.W. Song, Melvin D. Trousdale, Douglas Stevenson, Joel E. Schechter, Austin K. Mircheff, D. M. Samant, Padmaja B. Thomas, Z. Zhu

Publikováno v: Journal of Autoimmunity. 31:116-122

Autologous peripheral blood lymphocytes (PBL), activated in a mixed cell reaction when co-cultured with purified rabbit lacrimal epithelial cells, are known to induce a Sjőgren’s-like autoimmune dacryoadenitis and keratoconjunctivitis when injecte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f793a60cff924c25e3d837580062d19
https://doi.org/10.1016/j.jaut.2008.04.019

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Traffic of endogenous, transduced, and endocytosed prolactin in rabbit lacrimal acinar cells

Autor: Yanru Wang, Sarah F. Hamm-Alvarez, Barbara Petridou, T. Nakamura, Ameae M. Walker, C.T. Chiu, Austin K. Mircheff, Joel E. Schechter, Melvin D. Trousdale

Publikováno v: Experimental Eye Research
Experimental Eye Research, Elsevier, 2007, 85 (6), pp.749-761

The rabbit lacrimal gland undergoes an immunophysiological transformation during pregnancy, reminiscent of that of the mammary gland as it prepares to deliver secretory IgA into the nascent fluid product. The contents of TGF-beta and prolactin (PRL)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffd97cd8d3ed1598dc362cce7428377
https://doi.org/10.1016/j.exer.2007.08.009

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Tissue-engineered tear secretory system: Functional lacrimal gland acinar cells cultured on matrix protein-coated substrata

Autor: Jean T. Jacob, Melvin D. Trousdale, Joel E. Schechter, Padmaja B. Thomas, Samuel C. Yiu, Ronald E. Smith, Shivaram Selvam, Douglas Stevenson, Austin K. Mircheff

Publikováno v: Journal of Biomedical Materials Research Part B: Applied Biomaterials. :192-200

Dry eye is a general term that refers to a myriad of ophthalmic disorders resulting in the inadequate wetting of the corneal surface by the tear film. Dry eyes are typically treated by the application of artificial tears. However, patients with lacri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e9c9cc0c96cee8b065114ea37bee099
https://doi.org/10.1002/jbm.b.30584

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Mucosal Immunity and Self-Tolerance in the Ocular Surface System

Autor: Melvin D. Trousdale, Magdalena Baladud de Saint Jean, Sarah F. Hamm-Alvarez, Yanru Wang, Chuanqing Ding, Austin K. Mircheff, Joel E. Schechter

Publikováno v: The Ocular Surface. 3:182-193

This paper articulates a new working hypothesis that explains many of the pathophysiological conditions described under the common rubric "dry eye" as altered states of mucosal immune regulation. A central principle of mucosal immune physiology is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9dee58929902f464f8ced1650edf4a
https://doi.org/10.1016/s1542-0124(12)70204-5

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Impairment of conjunctival glutathione secretion and ion transport by oxidative stress in an adenovirus type 5 ocular infection model of pigmented rabbits

Autor: Wenzheng Zhang, Hovhannes J. Gukasyan, Kwang-Jin Kim, Vincent H.L. Lee, Ram Kannan, Melvin D. Trousdale

Publikováno v: Free Radical Biology and Medicine. 37:229-238

Conjunctival epithelial cells of pigmented rabbits secrete reduced glutathione (GSH) into the apical (mucosal) fluid. The aim of the current study was to determine the effect of oxidative stress resulting from viral infection and that of GSH suppleme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9881f62f45a65091efabeca991c54a8
https://doi.org/10.1016/j.freeradbiomed.2004.04.030

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