Tandem-trapped ion mobility spectrometry/mass spectrometry (tTIMS/MS): a promising analytical method for investigating heterogenous samples

Autor: Fanny C. Liu, Mark E. Ridgeway, Melvin A. Park, Christian Bleiholder

Publikováno v: Analyst

Ion mobility spectrometry/mass spectrometry (IMS/MS) is widely used to study various levels of protein structure. Here, we review the current state of affairs in tandem-trapped ion mobility spectrometry/mass spectrometry (tTIMS/MS). Two different tTI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96c5995c79979bac7d1dad9d01c1222
https://doi.org/10.1039/d2an00335j

Implications of Blanc’s Law for Use in Trapped Ion Mobility Spectrometry

Autor: Cameron N. Naylor, Tobias Reinecke, Mark E. Ridgeway, Melvin A. Park, Brian H. Clowers

Publikováno v: Journal of the American Society for Mass Spectrometry. 32:2241-2250

Blanc's Law has served as a way to predict the mobilities of ions in mixed drift gases for over 100 years yet has remained largely unexplored using newer ion mobility spectrometry (IMS) configurations, including traveling wave and trapped IMS (TIMS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bd828042cef9a076a0e60e20767ca9
https://doi.org/10.1021/jasms.1c00168

Trapped Ion Mobility Spectrometry of Native Macromolecular Assemblies

Autor: Yuk-Ching Tse-Dinh, Francisco Fernandez-Lima, Alyssa Garabedian, Mark E. Ridgeway, Melvin A. Park, Kevin Jeanne Dit Fouque, Fenfei Leng

Publikováno v: Anal Chem

The structural elucidation of native macromolecular assemblies has been a subject of considerable interest in native mass spectrometry (MS), and more recently in tandem with ion mobility spectrometry (IMS-MS), for a better understanding of their bioc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb2bedce256c86e215b0ca051ab6b24
https://doi.org/10.1021/acs.analchem.0c04556

Ultra‐high sensitivity mass spectrometry quantifies single‐cell proteome changes upon perturbation

Autor: Nicolai Bache, Melvin A. Park, Ole Bjeld Horning, Constantin Ammar, Florian Meier, Andreas Mund, Fabian Coscia, David S. Fischer, Marvin Thielert, Matthias Mann, Oliver Raether, Amalia Apalategui, Catherine G. Vasilopoulou, Andreas-David Brunner, Markus Lubeck, Fabian J. Theis, Sabrina Richter

Publikováno v: bioRxiv
Mol. Syst. Biol. 18:e10798 (2022)
Brunner, A-D, Thielert, M, Vasilopoulou, C, Ammar, C, Coscia, F, Mund, A, Hoerning, O B, Bache, N, Apalategui, A, Lubeck, M, Richter, S, Fischer, D S, Raether, O, Park, M A, Meier, F, Theis, F J & Mann, M 2022, ' Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation ', Molecular Systems Biology, vol. 18, no. 3, e10798 . https://doi.org/10.15252/msb.202110798

Single-cell technologies are revolutionizing biology but are today mainly limited to imaging and deep sequencing1–3. However, proteins are the main drivers of cellular function and in-depth characterization of individual cells by mass spectrometry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f08a75b6b0e9d95b9128badde6f987c
https://doi.org/10.15252/msb.202110798

Trapped Ion Mobility Spectrometry and Parallel Accumulation–Serial Fragmentation in Proteomics

Autor: Florian Meier, Melvin A. Park, Matthias Mann

Publikováno v: Molecular & Cellular Proteomics : MCP

Recent advances in efficiency and ease of implementation have rekindled interest in ion mobility spectrometry, a technique that separates gas phase ions by their size and shape and that can be hybridized with conventional LC and MS. Here, we review t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e97aa36ff3b8962986c3ce9a13891fb2
http://europepmc.org/articles/PMC8453224