The Impact of SIV-Induced Immunodeficiency on SARS-CoV-2 Disease, Viral Dynamics, and Antiviral Immune Response in a Nonhuman Primate Model of Coinfection.

Autor: Melton A; Tulane National Primate Research Center, Covington, LA 70433, USA.; Biomedical Science Training Program, Tulane University School of Medicine, New Orleans, LA 70112, USA., Rowe LA; Tulane National Primate Research Center, Covington, LA 70433, USA., Penney T; Tulane National Primate Research Center, Covington, LA 70433, USA., Krzykwa C; Tulane National Primate Research Center, Covington, LA 70433, USA., Goff K; Tulane National Primate Research Center, Covington, LA 70433, USA., Scheuermann SE; Tulane National Primate Research Center, Covington, LA 70433, USA., Melton HJ; Department of Statistics, Florida State University, Tallahassee, FL 32306, USA., Williams K; Tulane National Primate Research Center, Covington, LA 70433, USA., Golden N; Tulane National Primate Research Center, Covington, LA 70433, USA., Green KM; Tulane National Primate Research Center, Covington, LA 70433, USA., Smith B; Tulane National Primate Research Center, Covington, LA 70433, USA., Russell-Lodrigue K; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Dufour JP; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Doyle-Meyers LA; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Schiro F; Tulane National Primate Research Center, Covington, LA 70433, USA., Aye PP; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Lifson JD; AIDS and Cancer Viruses Program, Frederick National Laboratory, Frederick, MD 21701, USA., Beddingfield BJ; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Blair RV; Tulane National Primate Research Center, Covington, LA 70433, USA., Bohm RP; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Kolls JK; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Rappaport J; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA., Hoxie JA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Maness NJ; Tulane National Primate Research Center, Covington, LA 70433, USA.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA 70112, USA.

Publikováno v: Viruses [Viruses] 2024 Jul 21; Vol. 16 (7). Date of Electronic Publication: 2024 Jul 21.

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection.

Autor: Melton A; Tulane National Primate Research Center, Covington, Louisiana.; Biomedical Science Training Program, Tulane University School of Medicine, New Orleans, Louisiana., Rowe LA; Tulane National Primate Research Center, Covington, Louisiana., Penney T; Tulane National Primate Research Center, Covington, Louisiana., Krzykwa C; Tulane National Primate Research Center, Covington, Louisiana., Goff K; Tulane National Primate Research Center, Covington, Louisiana., Scheuermann S; Tulane National Primate Research Center, Covington, Louisiana., Melton HJ; Florida State University, Department of Statistics, Tallahassee, Florida., Williams K; Tulane National Primate Research Center, Covington, Louisiana., Golden N; Tulane National Primate Research Center, Covington, Louisiana., Green KM; Tulane National Primate Research Center, Covington, Louisiana., Smith B; Tulane National Primate Research Center, Covington, Louisiana., Russell-Lodrigue K; Tulane National Primate Research Center, Covington, Louisiana.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana., Dufour JP; Tulane National Primate Research Center, Covington, Louisiana.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana., Doyle-Meyers LA; Tulane National Primate Research Center, Covington, Louisiana.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana., Schiro F; Tulane National Primate Research Center, Covington, Louisiana., Aye PP; Tulane National Primate Research Center, Covington, Louisiana.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana., Lifson JD; AIDS and Cancer Viruses Program, Frederick National Laboratory, Frederick, Maryland, United States of America., Beddingfield BJ; Tulane National Primate Research Center, Covington, Louisiana.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana., Blair RV; Tulane National Primate Research Center, Covington, Louisiana., Bohm RP; Tulane National Primate Research Center, Covington, Louisiana.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana.; Present address: Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon., Kolls JK; Departments of Medicine and Pediatrics, Center for Translational Research in Infection and Inflammation, Tulane University School of Medicine, New Orleans, LA 70112, USA.; Department of Pulmonary Critical Care and Environmental Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA., Rappaport J; Tulane National Primate Research Center, Covington, Louisiana.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana., Hoxie JA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Maness NJ; Tulane National Primate Research Center, Covington, Louisiana.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 16. Date of Electronic Publication: 2023 Nov 16.

MIMOSA: A resource consisting of improved methylome imputation models increases power to identify DNA methylation-phenotype associations.

Autor: Melton HJ; Department of Statistics, Florida State University., Zhang Z; Department of Statistics, Florida State University., Deng HW; Cancer Epidemiology Division, University of Hawaii Cancer Center., Wu L; Center of Bioinformatics and Genomics, Tulane University., Wu C; Department of Biostatistics, University of Texas MD Anderson Cancer Center.

Publikováno v: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Oct 04. Date of Electronic Publication: 2023 Oct 04.

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease.

Autor: Melton A; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Biomedical Science Training Program, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Doyle-Meyers LA; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Blair RV; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Midkiff C; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Melton HJ; Florida State University, Department of Statistics, Tallahassee, Florida, United States of America., Russell-Lodrigue K; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Aye PP; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Schiro F; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Fahlberg M; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Szeltner D; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Spencer S; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Beddingfield BJ; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Goff K; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Golden N; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Penney T; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Picou B; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Hensley K; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Chandler KE; Tulane National Primate Research Center, Covington, Louisiana, United States of America., Plante JA; World Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America., Plante KS; World Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America., Weaver SC; World Reference Center for Emerging Viruses and Arboviruses, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, United States of America., Roy CJ; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Hoxie JA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Gao H; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, United States of America., Montefiori DC; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, United States of America., Mankowski JL; Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America., Bohm RP; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Rappaport J; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America., Maness NJ; Tulane National Primate Research Center, Covington, Louisiana, United States of America.; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, United States of America.

Publikováno v: PLoS pathogens [PLoS Pathog] 2021 Dec 20; Vol. 17 (12), pp. e1010162. Date of Electronic Publication: 2021 Dec 20 (Print Publication: 2021).