Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs.

Autor: Saintilnord WN, Hegazy YA, Chesnutt K, Eckstein M, Cassidy RN, Dhahri H, Bennett RL, Melters DP, Lopes E, Fu Z, Lau K, Chandler DP, Poirier MG, Dalal Y, Licht JD, Fondufe-Mittendorf Y

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Nov 21. Date of Electronic Publication: 2024 Nov 21.

Single molecule analysis of CENP-A chromatin by high-speed atomic force microscopy.

Autor: Melters DP; National Cancer Institute, Center for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, United States., Neuman KC; National Heart, Lung, and Blood Institute, Laboratory of Single Molecule Biophysics, Bethesda, United States., Bentahar RS; National Cancer Institute, Center for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, United States., Rakshit T; National Cancer Institute, Center for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, United States.; Department of Chemistry, Shiv Nadar University, Dadri, India., Dalal Y; National Cancer Institute, Center for Cancer Research, Laboratory Receptor Biology and Gene Expression, Bethesda, United States.

Publikováno v: ELife [Elife] 2023 Sep 20; Vol. 12. Date of Electronic Publication: 2023 Sep 20.

A hyper-quiescent chromatin state formed during aging is reversed by regeneration.

Autor: Yang N; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Occean JR; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Melters DP; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 21224, USA., Shi C; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Wang L; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Stransky S; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY 10461, USA., Doyle ME; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Cui CY; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Delannoy M; JHU SOM Microscope Facility, Johns Hopkins University, Baltimore, MD 21205, USA., Fan J; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Slama E; Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD 21229, USA., Egan JM; Laboratory of Clinical Investigation, National Institute on Aging, NIH, Baltimore, MD 21224, USA., De S; Computational Biology and Genomics Core, Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Cunningham SC; Department of Surgery, Ascension Saint Agnes Hospital, Baltimore, MD 21229, USA., de Cabo R; Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA., Sidoli S; Department of Biochemistry, Albert Einstein School of Medicine, Bronx, NY 10461, USA., Dalal Y; Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, NIH, Bethesda, MD 21224, USA., Sen P; Laboratory of Genetics and Genomics, National Institute on Aging, NIH, Baltimore, MD 21224, USA. Electronic address: payel.sen@nih.gov.

Publikováno v: Molecular cell [Mol Cell] 2023 May 18; Vol. 83 (10), pp. 1659-1676.e11. Date of Electronic Publication: 2023 Apr 27.

Breaking the aging epigenetic barrier.

Autor: Sikder S; Chromatin Structure and Epigenetic Mechanisms, Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI, NIH, Bethesda, MD, United States., Arunkumar G; Chromatin Structure and Epigenetic Mechanisms, Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI, NIH, Bethesda, MD, United States., Melters DP; Chromatin Structure and Epigenetic Mechanisms, Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI, NIH, Bethesda, MD, United States., Dalal Y; Chromatin Structure and Epigenetic Mechanisms, Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, NCI, NIH, Bethesda, MD, United States.

Publikováno v: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2022 Jul 28; Vol. 10, pp. 943519. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).

Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy.

Autor: Rakshit T; Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD, USA.; Department of Chemical, Biological & Macromolecular Sciences, S. N. Bose National Centre for Basic Sciences , Salt Lake, India., Melters DP; Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD, USA., Dimitriadis EK; Trans-NIH Shared Resource on Biomedical Engineering and Physical Science, National Cancer Institute, NIH , Bethesda, MD, USA., Dalal Y; Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Cancer Institute, NIH , Bethesda, MD, USA.

Publikováno v: Nucleus (Austin, Tex.) [Nucleus] 2020 Dec; Vol. 11 (1), pp. 264-282.