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Akademický článek

Highly immunogenic and fully synthetic peptide-carrier constructs targetting GNRH

Autor: Beekman, N.J.C.M ^{a, b}, Schaaper, W.M.M ^{a, *}, Turkstra, J.A ^a, Meloen, R.H ^a

Publikováno v: In Vaccine 1999 17(15):2043-2050

Pharmacological and toxicological assessment of a potential GnRH vaccine in young-adult male pigs

Autor: Turkstra, J.A., van der Staay, F.J., Stockhofe-Zurwieden, N., Woelders, H., Meloen, R.H., Schuurman, T., Emotion and Cognition, Dep Gezondheidszorg Landbouwhuisdieren

Publikováno v: Vaccine, 29, 3791. Elsevier
Vaccine, 29(21), 3791-3801
Vaccine 29 (2011) 21

Active immunization against gonadotrophin-releasing hormone (GnRH) is successfully applied to prevent boar taint in pork. In men, GnRH immunization could be an alternative to hormone therapy in patients with prostate cancer. In this study, a new GnRH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c826523ba25d9f14a11e2d954b9d7db3
https://dspace.library.uu.nl/handle/1874/236203

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Multidrug-resistant tumor cells remain sensitive to a recombinant interleukin-4-Pseudomonas exotoxin, except when overexpressing the multidrug resistance protein MRP1

Autor: de Jong, M.C., Scheffer, G.L., Broxterman, H.J., Hooijberg, J.H., Slootstra, J.W., Meloen, R.H., Kreitman, R.J., Husain, S.R., Joshi, B.H., Puri, R.K., Scheper, R.J.

Publikováno v: Clinical Cancer Research 9 (2003) 13
Clinical Cancer Research, 9(13), 5009-5017

Tumor cells may become resistant to conventional anticancer drugs through the occurrence of transmembrane transporter proteins such as P-glycoprotein (ABCB1), breast cancer resistance protein (ABCG2), or members of the multidrug resistance-associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c222100d71c27abc4bd776d64d104868
https://research.wur.nl/en/publications/multidrug-resistant-tumor-cells-remain-sensitive-to-a-recombinant

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Performance of male pigs immunized against GnRH is related to the time of onset of biological response

Autor: Turkstra, J.A., van Diepen, J.T.M., Jongbloed, A.W., Oonk, H.B., van de Wiel, D.F.M., Meloen, R.H.

Publikováno v: Journal of Animal Science, 80
Journal of Animal Science 80 (2002)

In this study, the performance of male pigs immunized against GnRH was determined in relation to the onset of their biological response to the immunization. Pigs were immunized at 9 and 17 wk of age and were housed in a pen together with both a surgi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0785255b1c86b6d64e2ac44b7abf61e7
https://research.wur.nl/en/publications/performance-of-male-pigs-immunized-against-gnrh-is-related-to-the

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The nature of the bond between peptide and carrier molecule determines immunogenicity of the construct

Autor: Beekman, N.L.C.M., Schaaper, W.M.M., Langeveld, J.P.M., Boshuizen, R.S., Meloen, R.H.

Publikováno v: Journal of peptide research, 58(3), 237-245
Journal of peptide research 58 (2001) 3

The influence of the nature of the bond between a peptide and a (lipidic) carrier molecule on the immunogenicity of that construct was investigated. As types of bonds a thioester-, a disulfide-, an amide- and a thioether bond were investigated. As ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b752c0b7e7026d186a4aaa1d12c2b3f5
https://research.wur.nl/en/publications/the-nature-of-the-bond-between-peptide-and-carrier-molecule-deter

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