Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Melody Zhao"'
Autor:
Ching Serena Kao, Rebekah van Bruggen, Jihye Rachel Kim, Xiao Xiao Lily Chen, Cadia Chan, Jooyun Lee, Woo In Cho, Melody Zhao, Claudia Arndt, Katarina Maksimovic, Mashiat Khan, Qiumin Tan, Michael D. Wilson, Jeehye Park
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
MATR3 is an ALS-linked gene. Here the authors describe a mutant MATR3 knockin mouse, which mimics some aspects of early-stage ALS.
Externí odkaz:
https://doaj.org/article/0a3728efa1014765b5026bca91c3ff8d
Autor:
Deivid C. Rodrigues, Dae-Sung Kim, Guang Yang, Kirill Zaslavsky, Kevin C.H. Ha, Rebecca S.F. Mok, P. Joel Ross, Melody Zhao, Alina Piekna, Wei Wei, Benjamin J. Blencowe, Quaid Morris, James Ellis
Publikováno v:
Cell Reports, Vol 17, Iss 3, Pp 720-734 (2016)
A progressive increase in MECP2 protein levels is a crucial and precisely regulated event during neurodevelopment, but the underlying mechanism is unclear. We report that MECP2 is regulated post-transcriptionally during in vitro differentiation of hu
Externí odkaz:
https://doaj.org/article/55dd7c868803470c80fd0349885b27c3
Publikováno v:
Targeted Oncology. 18:327-358
Autor:
Christopher Drudge, Melody Zhao, Satoru Tanaka, Nozomu Tanaka, Hiromichi Otaka, Izumi Kawachi, Dieter A. Häring, Róisín Brennan, Nicholas Adlard, Imtiaz A. Samjoo
Publikováno v:
Clinical and Experimental Neuroimmunology. 13:234-245
Autor:
Chris Cameron, Evelyn Worthington, Melody Zhao, Luisa Klotz, Dieter A. Häring, Christopher Drudge, Imtiaz A. Samjoo, Nicholas Adlard, Dee Stoneman
Publikováno v:
Journal of Comparative Effectiveness Research. 10:495-507
Background: The Association of British Neurologists (ABN) 2015 guidelines suggested classifying multiple sclerosis therapies according to their average relapse reduction. We sought to classify newer therapies (cladribine, ocrelizumab, ofatumumab, oza
Autor:
Luisa Klotz, Nicholas Adlard, Melody Zhao, Dieter A. Häring, Chris Cameron, Christopher Drudge, Imtiaz A. Samjoo, Dee Stoneman, Evelyn Worthington
Publikováno v:
Journal of Comparative Effectiveness Research. 9:1255-1274
Aim: To compare the efficacy of ofatumumab to other disease-modifying therapies (DMTs) for relapsing multiple sclerosis (RMS). Materials & methods: A network meta-analysis was conducted to determine the relative effect of ofatumumab on annualized rel
Autor:
Mashiat Khan, Xiao Xiao Lily Chen, Jooyun Lee, Qiumin Tan, Michael D. Wilson, Claudia Arndt, Jihye Rachel Kim, Jeehye Park, Rebekah van Bruggen, Ching Serena Kao, Melody Zhao, Cadia Chan, Woo In Cho, Katarina Maksimovic
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Nature Communications
A missense mutation, S85C, in the MATR3 gene is a genetic cause for amyotrophic lateral sclerosis (ALS). It is unclear how the S85C mutation affects MATR3 function and contributes to disease. Here, we develop a mouse model that harbors the S85C mutat
Autor:
Evelyn Worthington, Nicholas Adlard, Imtiaz A. Samjoo, Dee Stoneman, Christopher Drudge, Chris Cameron, Melody Zhao, Luisa Klotz, Dieter A. Häring
Publikováno v:
Journal of comparative effectiveness research. 10(17)
Autor:
Imtiaz A. Samjoo, Luisa Klotz, Gavin Giovannoni, Christopher Drudge, Anja Haltner, Evelyn Worthington, Melody Zhao, Róisín Brennan, Dieter A. Häring, Chris Cameron, Nicholas Adlard
Publikováno v:
Multiple Sclerosis and Related Disorders. 66:104031
Ofatumumab is a subcutaneously administered anti-CD20 monoclonal antibody (MoAb) therapy that has been evaluated in two identically designed randomized controlled trials (RCTs), ASCLEPIOS I (NCT02792218) and ASCLEPIOS II (NCT02792231), in patients wi
Autor:
Alina Piekna, Michael W. Salter, Eric Deneault, Stephen W. Scherer, Peter Pasceri, Wei Wei, Tadeo Thompson, James Ellis, P. Joel Ross, Fraser P. McCready, Deivid C. Rodrigues, Kirill Zaslavsky, Wen-Bo Zhang, Melody Zhao, Joelle El Hajjar, Caitlin Loo, Zhuozhi Wang, Marat Mufteev, Shahryar Khattak, Asli Romm
Publikováno v:
Nature neuroscience
Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum disorder (ASD). We generated cortical neurons from induced pluripotent stem cells (iPSC) derived from neurotypic and ASD-affected donors. We developed Sparse cocult