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pro vyhledávání: '"Melody Mills"'
Autor:
Melody Mills, Mary K. Estes
Publikováno v:
Drug Discovery Today. 21:1540-1552
Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research. Lack of suitable animal models, the need for better predictors of human immune responses, and pathogens that grow poorly or not
Autor:
Valentina Di Francesco, Jean E. McEwen, Carl C. Baker, Jeffery A. Schloss, Samir Zakhari, Susan Garges, Bracie Watson, Tsegahiwot Belachew, Kris A. Wetterstrand, Matthew E. Portnoy, Michael H. Sayre, A. Roger Little, Beena Akolkar, Carolyn Deal, Lindsey Grandison, Jane Peterson, Michael Wright, Lisa Begg, Jag H. Khalsa, Pamela Starke-Reed, Rachelle Salomon, Jennifer S. Read, Hannah Peavy, Robert W. Karp, T. Kevin Howcroft, Christina Giblin, Chris Mullins, Cindy D. Davis, Pamela McInnes, Christopher Wellington, Lu Wang, R. Dwayne Lunsford, Melody Mills, Hagit David, Maria Y. Giovanni, Carol H. Pontzer, Vivien Bonazzi, Michael C. Humble, Mark S. Guyer
Publikováno v:
The Human Microbiota
The Human Microbiome Project (HMP), funded as an initiative of the NIH Roadmap for Biomedical Research (http://nihroadmap.nih.gov), is a multi-component community resource. The goals of the HMP are: (1) to take advantage of new, high-throughput techn
Publikováno v:
Infection and Immunity. 70:2414-2418
Cattle are important reservoirs of enterohemorrhagic Escherichia coli (EHEC) O157:H7 that cause disease in humans. Both dairy and beef cattle are asymptomatically and sporadically infected with EHEC. Our long-term goal is to develop an effective vacc
Publikováno v:
Infection and Immunity. 69:2066-2074
Cytotoxic necrotizing factor type 1 (CNF1) of uropathogenic Escherichia coli belongs to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivat
Autor:
Melody Mills, Shelley M. Payne
Publikováno v:
Infection and Immunity. 65:5358-5363
shuA encodes a 70-kDa outer membrane heme receptor in Shigella dysenteriae. Analysis of the shuA DNA sequence indicates that this gene encodes a protein with homology to TonB-dependent receptors of gram-negative bacteria. Transport of heme by the Shu
Autor:
Melody Mills, Shelley M. Payne
Publikováno v:
Journal of Bacteriology. 177:3004-3009
Shigella species can use heme as the sole source of iron. In this work, the heme utilization locus of Shigella dysenteriae was cloned and characterized. A cosmid bank of S. dysenteriae serotype 1 DNA was constructed in an Escherichia coli siderophore
Publikováno v:
Infection and immunity. 68(10)
Pathogenic Escherichia coli associated with urinary tract infections (UTIs) in otherwise healthy individuals frequently produce cytotoxic necrotizing factor type 1 (CNF1), a member of the family of bacterial toxins that target the Rho family of small
Autor:
Kamiel Maase, Alfredo G. Torres, Elizabeth E. Wyckoff, Melody Mills, Donald Duncan, Shelley M. Payne
Publikováno v:
Molecular microbiology. 28(6)
The ability to transport and use haemin as an iron source is frequently observed in clinical isolates of Shigella spp. and pathogenic Escherichia coli. We found that many of these haem-utilizing E. coli strains contain a gene that hybridizes at high