Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Melody E. Clark"'
Autor:
Marjory L. Givens, Mark P. Kamps, Pamela L. Mellon, Naama Rave-Harel, Sara B. Hall, Melody E. Clark, Hao A. Duong, Djurdjica Coss, Shelley B. Nelson
Publikováno v:
Journal of Biological Chemistry. 279:30287-30297
Gonadotropin-releasing hormone (GnRH) is the central regulator of reproductive function. Expression of the GnRH gene is confined to a rare population of neurons scattered throughout the hypothalamus. Restricted expression of the rat GnRH gene is driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f36207393ee7ddcfe1b7c606ddcd0e
https://doi.org/10.1074/jbc.m402960200
https://doi.org/10.1074/jbc.m402960200
Autor:
Mark A. Lawson, Jolene J. Windle, Pamela L. Mellon, David B. Whyte, Satish A. Eraly, Melody E. Clark, Denise D. Belsham
Publikováno v:
Methods. 7:303-310
The neuroendocrine hypothalamus has been the object of intensive study in vivo and in tissue slices. However, using these models it is difficult to approach questions at the molecular and cellular level and to differentiate between direct effects and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26114d592c6a9e66c37d21403be055d4
https://doi.org/10.1006/meth.1995.1036
https://doi.org/10.1006/meth.1995.1036
The Otx2 homeoprotein regulates expression from the gonadotropin-releasing hormone proximal promoter
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 14(8)
The GnRH gene is expressed exclusively in a highly restricted population of approximately 800 neurons in the mediobasal hypothalamus in the mouse. The Otx2 homeoprotein has been shown to colocalize with GnRH in embryonic mouse brain. We have identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1b25e71432c959e5270d7c53ed23c80
https://pubmed.ncbi.nlm.nih.gov/10935548
https://pubmed.ncbi.nlm.nih.gov/10935548
Summary In this review we have assembled the recent literature concerning the molecular aspects of GnRH gene regulation. Since investigation of the molecular mechanisms of gene expression requires an appropriate cell model system, we have focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::878e1700165a077367d3a5c1f2c77fb0
https://doi.org/10.1016/s1569-2566(97)80032-4
https://doi.org/10.1016/s1569-2566(97)80032-4
Autor:
Melody E. Clark, Pamela L. Mellon
The mechanisms of specification of gene expression in a complex tissue such as the brain remain poorly understood. To provide a model system for the study of gene regulation in a specific subpopulation of differentiated neurons, we have derived cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f078992720011422045c9aa0657ee62
https://europepmc.org/articles/PMC230868/
https://europepmc.org/articles/PMC230868/
Autor:
Melody E. Clark, Asim Dasgupta
Publikováno v:
Molecular and cellular biology. 10(10)
In HeLa cells, RNA polymerase III (pol III)-mediated transcription is severely inhibited by poliovirus infection. This inhibition is due primarily to the reduction in transcriptional activity of the pol III transcription factor TFIIIC in poliovirus-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336dfcca2d79c0b82589aa8d372164fa
https://pubmed.ncbi.nlm.nih.gov/2204807
https://pubmed.ncbi.nlm.nih.gov/2204807