Výsledky vyhledávání - "Meloche Sylvain"

Akademický článek

From basic research to clinical development of MEK1/2 inhibitors for cancer therapy

Autor: Meloche Sylvain, Frémin Christophe

Publikováno v: Journal of Hematology & Oncology, Vol 3, Iss 1, p 8 (2010)

Abstract The Ras-dependent Raf/MEK/ERK1/2 mitogen-activated protein (MAP) kinase signaling pathway is a major regulator of cell proliferation and survival. Not surprisingly, hyperactivation of this pathway is frequently observed in human malignancies

Externí odkaz: https://doaj.org/article/96111efe968a4115b5e0ebf0de0f5a50

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Akademický článek

ER stress affects processing of MHC class I-associated peptides

Autor: Meloche Sylvain, de Verteuil Danielle, Caron Étienne, Hardy Marie-Pierre, Tanguay Pierre-Luc, Granados Diana P, Perreault Claude

Publikováno v: BMC Immunology, Vol 10, Iss 1, p 10 (2009)

Abstract Background Viral infection and neoplastic transformation trigger endoplasmic reticulum (ER) stress. Thus, a large proportion of the cells that must be recognized by the immune system are stressed cells. Cells respond to ER stress by launchin

Externí odkaz: https://doaj.org/article/1517632a05e641269dd3df94db40ddc0

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Akademický článek

Activation of MEK1 or MEK2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors

Autor: Saba-El-Leil Marc K, Claveau Isabelle, Gopalbhai Kailesh, Duhamel Stéphanie, Julien Catherine, Voisin Laure, Rodrigue-Gervais Ian, Gaboury Louis, Lamarre Daniel, Basik Mark, Meloche Sylvain

Publikováno v: BMC Cancer, Vol 8, Iss 1, p 337 (2008)

Abstract Background The Ras-dependent ERK1/2 MAP kinase signaling pathway plays a central role in cell proliferation control and is frequently activated in human colorectal cancer. Small-molecule inhibitors of MEK1/MEK2 are therefore viewed as attrac

Externí odkaz: https://doaj.org/article/dfa1ee9c0ccf465c83bfe321e2d5e937

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