4-amino-2-phenyl-6-(p-fluorophenyl)-5-carbonitrile-pyrimidine-bis-substituted-loaded liposomes as promising system for cancer treatment

Autor: OLIVEIRA, JANICE V., ALMEIDA, GLEYBSON C., NOGUEIRA, MARIANE C.B.L., AGUIAR JÚNIOR, FRANCISCO C.A., MELO, AUDENES O., SILVA, THIAGO D.S., SANTOS, NOEMIA P.S., MAGALHÃES, NEREIDE S.S., MELO, SEBASTIÃO J., FALCÃO, EMERSON P.S.

Publikováno v: Anais da Academia Brasileira de Ciências, Volume: 95 Supplement 1, Article number: e20211078, Published: 10 JUL 2023

The aim of the present study was to perform in vitro and in vivo assessments of the antineoplastic action of 4-amino-pyrimidine encapsulated in liposomes. Liposomes were prepared and characterized for particle size and drug encapsulation and submitte

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652023000200603&lng=en&tlng=en

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Synthesis and cytotoxic profile of glycosyl–triazole linked to 1,2,4-oxadiazole moiety at C-5 through a straight-chain carbon and oxygen atoms

Autor: dos Anjos, Janaína V., Neves Filho, Ricardo A.W., do Nascimento, Silene C., Srivastava, Rajendra M., de Melo, Sebastião J., Sinou, Denis

Publikováno v: In European Journal of Medicinal Chemistry 2009 44(9):3571-3576

Pyrimidine Derivatives: QSAR Studies of Larvicidal Activity against Aedes aegypti

Autor: Monte,Zenaide S., Navarro,Daniela M. A. F., Aguiar,Júlio C. R. O. F., Nascimento,Jessica S., Scotti,Marcus T., Scotti,Luciana, Barros,Renata P. C., Santos,Aline C. S., Pereira,Valéria R. A., Falcão,Emerson P. S., Melo,Sebastião J.

Publikováno v: Journal of the Brazilian Chemical Society, Volume: 31, Issue: 7, Pages: 1531-1540, Published: 03 JUL 2020
Journal of the Brazilian Chemical Society v.31 n.7 2020
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ

The present study investigated the activity of pyrimidine derivatives against Aedes aegypti. Two compounds, 3c and 3d showed excellent larvicide activity. Additionally, quantitative structure-activity relationship (QSAR) models were built using multi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::fade631307fa605e6d8351ddb8318829
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532020000701531&lng=en&tlng=en

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