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Selectivity of kinase inhibitor fragments.

Autor: Bamborough P; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK. Paul.A.Bamborough@gsk.com, Brown MJ, Christopher JA, Chung CW, Mellor GW

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Discovery of 6-aryl-7-alkoxyisoquinoline inhibitors of IkappaB kinase-beta (IKK-beta).

Autor: Christopher JA; GlaxoSmithKline R&D, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK. john@christopher257.fsnet.co.uk, Bamborough P, Alder C, Campbell A, Cutler GJ, Down K, Hamadi AM, Jolly AM, Kerns JK, Lucas FS, Mellor GW, Miller DD, Morse MA, Pancholi KD, Rumsey W, Solanke YE, Williamson R

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Rational design of 4-amino-5,6-diaryl-furo[2,3-d]pyrimidines as potent glycogen synthase kinase-3 inhibitors.

Autor: Miyazaki Y; GlaxoSmithKline, Tsukuba Research Laboratories, Chemistry Department, 43, Wadai, Tsukuba, Ibaraki 300-4247, Japan., Maeda Y, Sato H, Nakano M, Mellor GW

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Mar 15; Vol. 18 (6), pp. 1967-71. Date of Electronic Publication: 2008 Feb 02.

DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation.

Autor: Mullen, Nicholas J., Shukla, Surendra K., Thakur, Ravi, Kollala, Sai Sundeep, Dezhen Wang, Chaika, Nina, Santana, Juan F., Miklavcic, William R., LaBreck, Drew A., Mallareddy, Jayapal Reddy, Price, David H., Natarajan, Amarnath, Mehla, Kamiya, Sykes, David B., Hollingsworth, Michael A., Singh, Pankaj K.

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