Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Mellissa Creighton"'
Autor:
George A. Doss, Nathan X. Yu, Yohannes Teffera, Suzanne L. Ciccotto, Stella H. Vincent, Wei Tang, Mellissa Creighton, M. Reza Anari, Richard Tschirret-Guth, Donald F. Hobra, John B. Coleman, Jason S. Ngui, David C. Evans
Publikováno v:
Drug Metabolism and Disposition. 34:1367-1375
The pharmacokinetics and metabolism of 1-(4-((4-phenyl-5-trifluoromethyl-2-thienyl)methoxy)benzyl)azetidine-3-carboxylic acid (MRL-A), a selective agonist for the sphingosine-1-phosphate 1 (S1P1) receptor, were investigated in rats and dogs. In both
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e33a1b6d8cf5cff2e7ab4f56b5c4903
https://doi.org/10.1124/dmd.105.009027
https://doi.org/10.1124/dmd.105.009027
Autor:
Vijay Bhasker G. Reddy, Christopher J. Kochansky, George A. Doss, Ronald B. Franklin, Bindhu V. Karanam, Mellissa Creighton, Stella H. Vincent
Publikováno v:
Drug Metabolism and Disposition. 32:1154-1161
MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl)phenyl]methyl]benzamide] is a novel thiazolidinedione-containing peroxisome proliferator-activated receptor alpha/gamma agonist. In rats dosed orally with [14C]MK-0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60946f21d9c59864efa8eca0043a6f75
https://doi.org/10.1124/dmd.104.000240
https://doi.org/10.1124/dmd.104.000240
Autor:
Christopher J, Kochansky, Yuan-Qing, Xia, Sui, Wang, Brian, Cato, Mellissa, Creighton, Stella H, Vincent, Ronald B, Franklin, James R, Reed
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(12)
A species difference was observed in the excretion pathway of 2-[[5,7-dipropyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy]-2-methylpropanoic acid (MRL-C), an alpha-weighted dual peroxisome proliferator-activated receptor alpha/gamma agonist. After
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a836090dbdd51cb3963ddec102c9c0e
https://pubmed.ncbi.nlm.nih.gov/16183782
https://pubmed.ncbi.nlm.nih.gov/16183782
Autor:
Mellissa Creighton, Stella H. Vincent, James R. Reed, Brian Cato, Sui Wang, Christopher J. Kochansky, Ronald B. Franklin, Yuan-Qing Xia
Publikováno v:
Drug Metabolism and Disposition.
A species difference was observed in the excretion pathway of 2-[[5,7-dipropyl-3-(trifluoromethyl)-1,2-benzisoxazol-6-yl]oxy]-2-methylpropanoic acid (MRL-C), an alpha-weighted dual peroxisome proliferator-activated receptor alpha/gamma agonist. After
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8c917859c94a356371d7c928d3f5e03
https://doi.org/10.1124/dmd.105.004010
https://doi.org/10.1124/dmd.105.004010
Autor:
R Eydelloth, Stella H. Vincent, Shuet-Hing Lee Chiu, Mellissa Creighton, Cornelis E. C. A. Hop, Alice R. Mao, F Tang, N Yu, Maria G. Beconi, Ronald B. Franklin
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 33(7)
1. The metabolism of a substituted 2,4-thiazolidinedione (P1) with dual PPARalpha/gamma activity was evaluated in male and female rats, dogs and monkeys. A para-hydroxylated metabolite (M1) with potent PPARgamma-selective agonist, was a major circula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb73efe8413a5bb1fb5905e53e364b92
https://pubmed.ncbi.nlm.nih.gov/12893525
https://pubmed.ncbi.nlm.nih.gov/12893525
Autor:
Y S Tang, W Feeney, J Szewczyk, David Q. Liu, J R Reed, Stella H. Vincent, Zhongzhou Shen, R Bakhtiar, Mellissa Creighton, Ronald B. Franklin, Donald F. Hora
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 33(5)
1. Four new metabolites of pioglitazone were identified by liquid chromatography-mass spectrometry (LC-MS/MS) as being formed by hydroxylation (M-VII and M-VIII), opening of the thiazolidinedione ring (M-X) and by desaturation of the terminal ethyl s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6912a6c60b7407d579f3799a54fc13a
https://pubmed.ncbi.nlm.nih.gov/12746106
https://pubmed.ncbi.nlm.nih.gov/12746106
Autor:
An-Hua Mao, Yi Tien Yang, Rena Ning Ren, Mitree M. Ponpipom, Stella H. Vincent, Jisong Cui, Joel B. Yudkovitz, Robert L. Bugianesi, George R. Mount, Mellissa Creighton, Kang Cheng, Joseph P. Simeone, Jane-Ling Lo, Mark T. Goulet
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(22)
The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0d9016909508805fb7efc6835dbb42
https://pubmed.ncbi.nlm.nih.gov/12392744
https://pubmed.ncbi.nlm.nih.gov/12392744