Comparative effects of CFTR modulators on phagocytic, metabolic and inflammatory profiles of CF and nonCF macrophages.

Autor: Aridgides DS; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. Daniel.S.Aridgides@hitchcock.org., Mellinger DL; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Gwilt LL; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Hampton TH; Department of Microbiology and Immunology, Dartmouth College, Geisel School of Medicine, Hanover, NH, USA., Mould DL; Department of Microbiology and Immunology, Dartmouth College, Geisel School of Medicine, Hanover, NH, USA., Hogan DA; Department of Microbiology and Immunology, Dartmouth College, Geisel School of Medicine, Hanover, NH, USA., Ashare A; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Department of Microbiology and Immunology, Dartmouth College, Geisel School of Medicine, Hanover, NH, USA.

Publikováno v: Scientific reports [Sci Rep] 2023 Jul 25; Vol. 13 (1), pp. 11995. Date of Electronic Publication: 2023 Jul 25.

Extracellular Vesicles from Pseudomonas aeruginosa Suppress MHC-Related Molecules in Human Lung Macrophages.

Autor: Armstrong DA; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756; david.a.armstrong@hitchcock.org., Lee MK; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756., Hazlett HF; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH 03755., Dessaint JA; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756., Mellinger DL; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756., Aridgides DS; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756., Hendricks GM; Department of Cell and Developmental Biology, University of Massachusetts Medical School, Worcester, MA 01655., Abdalla MAK; Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria 21526, Egypt; and., Christensen BC; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756., Ashare A; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH 03756.

Publikováno v: ImmunoHorizons [Immunohorizons] 2020 Aug 20; Vol. 4 (8), pp. 508-519. Date of Electronic Publication: 2020 Aug 20.

Functional and metabolic impairment in cigarette smoke-exposed macrophages is tied to oxidative stress.

Autor: Aridgides DS; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Mellinger DL; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Armstrong DA; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Hazlett HF; Department of Microbiology and Immunology, Geisel School of Medicine, Hanover, NH, USA., Dessaint JA; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Hampton TH; Department of Microbiology and Immunology, Geisel School of Medicine, Hanover, NH, USA., Atkins GT; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Carroll JL; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Ashare A; Section of Pulmonary and Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. Alix.Ashare@hitchcock.org.; Department of Microbiology and Immunology, Geisel School of Medicine, Hanover, NH, USA. Alix.Ashare@hitchcock.org.

Publikováno v: Scientific reports [Sci Rep] 2019 Jul 03; Vol. 9 (1), pp. 9624. Date of Electronic Publication: 2019 Jul 03.

Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis.

Autor: Chen Y; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Armstrong DA; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. David.A.Armstrong@hitchcock.org., Salas LA; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Hazlett HF; Program in Experimental and Molecular Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA., Nymon AB; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Dessaint JA; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Aridgides DS; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Mellinger DL; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Liu X; Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA., Christensen BC; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.; Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.; Department of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Ashare A; Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.; Program in Experimental and Molecular Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Publikováno v: Clinical epigenetics [Clin Epigenetics] 2018 Dec 10; Vol. 10 (1), pp. 152. Date of Electronic Publication: 2018 Dec 10.