A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles

Autor: Nguyen, Vivian V T, Ye, Shicheng, Gkouzioti, Vasiliki, van Wolferen, Monique E, Yengej, Fjodor Yousef, Melkert, Dennis, Siti, Sofia, de Jong, Bart, Besseling, Paul J, Spee, Bart, van der Laan, Luc J W, Horland, Reyk, Verhaar, Marianne C, van Balkom, Bas W M, Interne geneeskunde GD, CS_STEM

Publikováno v: Journal of Extracellular Vesicles, 11(11), 1. Co-Action Publishing
Journal of Extracellular Vesicles, 11(11):12280. Taylor & Francis Ltd

Mesenchymal stromal cell (MSC)-derived small extracellular vesicles (sEVs) show therapeutic potential in multiple disease models, including kidney injury. Clinical translation of sEVs requires further preclinical and regulatory developments, includin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd60e28461c4ed11800755ac5b553fa
https://dspace.library.uu.nl/handle/1874/424297

A human kidney and liver organoid-based multi-organ-on-a-chip model to study the therapeutic effects and biodistribution of mesenchymal stromal cell-derived extracellular vesicles.

Autor: Nguyen VVT; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., Ye S; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Gkouzioti V; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., van Wolferen ME; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., Yengej FY; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.; Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, The Netherlands., Melkert D; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., Siti S; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., de Jong B; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., Besseling PJ; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., Spee B; Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands., van der Laan LJW; Dept of Surgery, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands., Horland R; TissUse GmbH, Berlin, Germany., Verhaar MC; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands., van Balkom BWM; Department of Nephrology and Hypertension, UMC Utrecht, Utrecht, The Netherlands.

Publikováno v: Journal of extracellular vesicles [J Extracell Vesicles] 2022 Nov; Vol. 11 (11), pp. e12280.