Výsledky vyhledávání - "Melita B. Irving"

Acromesomelic Dysplasia, Type Maroteaux: Impact of Long-Term (8 Years) High-Dose Growth Hormone Treatment on Growth Velocity and Final Height in 2 Siblings

Autor: Simon Chapman, Ved Bhushan Arya, Melita B. Irving, Charles R. Buchanan, Maha Younes, Meena Raj, Ritika R. Kapoor

Publikováno v: Hormone research in paediatrics. 93(5)

Introduction: Acromesomelic dysplasia, type Maroteaux (AMDM) is a rare autosomal recessive skeletal dysplasia, characterized by severe dwarfism and disproportionate limb shortening. It results from loss-of-function NPR2 mutations affecting the C-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e125f09a7d43ce6a9e0500c1ce617d
https://pubmed.ncbi.nlm.nih.gov/33238275

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Exploring peptide mimics for the production of antibodies against discontinuous protein epitopes

Autor: Lisa Craig, Alfredo Menendez, Beechanahalli P. Gangadhar, Jamie K. Scott, Melita B. Irving, Nienke E. van Houten, Marinieve Montero

Publikováno v: Molecular Immunology

Peptide “mimics” (mimotopes) of linear protein epitopes and carbohydrate epitopes have been successfully used as immunogens to elicit cross-reactive antibodies against their cognate epitopes; however, immunogenic mimicry has been difficult to ach

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218c614ef073a20329e1faa751c4559c

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Identification and Characterization of a Peptide That Specifically Binds the Human, Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody b12

Autor: Jamie K. Scott, Paul W. H. I. Parren, Melita B. Irving, Lori L. C. Bonnycastle, Carlos F. Barbas, Michael B. Zwick, Dennis R. Burton, Alfredo Menendez

Publikováno v: Journal of Virology. 75:6692-6699

Human monoclonal antibody (MAb) b12 recognizes a conformational epitope that overlaps the CD-4-binding site of the human immunodeficiency virus type 1 (HIV-1) envelope. MAb b12 neutralizes a broad range of HIV-1 primary isolates and protects against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779e8b3980c44fea7efb857784c08732
https://doi.org/10.1128/jvi.75.14.6692-6699.2001

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Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics

Autor: Jamie K. Scott, Oscar C.C. Pan, Melita B. Irving

Publikováno v: Current Opinion in Chemical Biology

Random peptide libraries and antigen-fragment libraries (also known as gene-fragment libraries) have been used to identify epitopes on protein antigens. These technologies promise to make significant contributions to diagnostic and vaccine developmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf2d5f7f5fff3a2e0dac0ec9bc85343
https://doi.org/10.1016/s1367-5931(00)00208-8

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