Single and two-dose typhoid conjugate vaccine safety and immunogenicity in HIV-exposed uninfected and HIV-unexposed uninfected Malawian children

Autor: Nginache Nampota-Nkomba, Osward M. Nyirenda, Victoria Mapemba, Rhoda Masonga, Priyanka D. Patel, Theresa Misiri, Felistas Mwakiseghile, Richard Wachepa, John M. Ndaferankhande, Bright Lipenga, Pratiksha Patel, Happy Banda, Jennifer Oshinsky, Marcela F. Pasetti, Robert S. Heyderman, Leslie P. Jamka, Divya Hosangadi, Shrimati Datta, Melita A. Gordon, Kathleen M. Neuzil, Matthew B. Laurens

Publikováno v: Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)

Vaccine safety and immunogenicity data in human immunodeficiency virus (HIV)-exposed uninfected (HEU) children are important for decision-making in HIV and typhoid co-endemic countries. In an open-label study, we recruited Malawian HEU and HIV unexpo

Externí odkaz: https://doaj.org/article/f07e042e084547c98e965b494eb39f5a

Protocol for the challenge non-typhoidal Salmonella (CHANTS) study: a first-in-human, in-patient, double-blind, randomised, safety and dose-escalation controlled human infection model in the UK

Autor: Melita A Gordon, Christopher Smith, Xinxue Liu, Andrew J Pollard, Emma Smith, Graham S Cooke, Robert K M Choy, Anna Rydlova, Robert Varro, Jay C D Hinton, Christopher Chiu, Malick M Gibani

Publikováno v: BMJ Open, Vol 14, Iss 1 (2024)

Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting, Salmonella enterica serovar Typhimurium accounts for two-thirds of infections

Externí odkaz: https://doaj.org/article/1918efc4b7e8470281477786c25f07d8

Salmonella Vaccine Study in Oxford (SALVO) trial: protocol for an observer-participant blind randomised placebo-controlled trial of the iNTS-GMMA vaccine within a European cohort

Autor: Melita A Gordon, Ellis Owusu-Dabo, Florian Marks, Carsten Mantel, Andrew J Pollard, Brama Hanumunthadu, Rachel White, John A Crump, Hannah Robinson, Jan Jacobs, Samuel Kariuki, Bieke Tack, Stefano Malvolti, Nasir Kanji, Nelly Owino, Carla Ferreira Da Silva, Pietro Ferruzzi, Usman Nakakana, Rocio Canals, Maheshi Ramasamy, Francis Agyapong, Gianluca Breghi, Fabio Fiorino, Christian S. Marchello, Donata Medaglini, Esther M. Muthumbi, Chisomo L. Msefula, Tonney S. Nyirenda, Robert Onsare, Elena Pettini, Anthony G Scott J, Bassiahi Abdramane Soura, Tiziana Spadafina

Publikováno v: BMJ Open, Vol 13, Iss 11 (2023)

Introduction Invasive non-typhoidal Salmonellosis (iNTS) is mainly caused by Salmonella enterica serovars Typhimurium and Enteritidis and is estimated to result in 77 500 deaths per year, disproportionately affecting children under 5 years of age in

Externí odkaz: https://doaj.org/article/7f29c2eaf5e042f4a8bfa23fb84777a2

Global diversity and antimicrobial resistance of typhoid fever pathogens: Insights from a meta-analysis of 13,000 Salmonella Typhi genomes

Autor: Megan E Carey, Zoe A Dyson, Danielle J Ingle, Afreenish Amir, Mabel K Aworh, Marie Anne Chattaway, Ka Lip Chew, John A Crump, Nicholas A Feasey, Benjamin P Howden, Karen H Keddy, Mailis Maes, Christopher M Parry, Sandra Van Puyvelde, Hattie E Webb, Ayorinde Oluwatobiloba Afolayan, Anna P Alexander, Shalini Anandan, Jason R Andrews, Philip M Ashton, Buddha Basnyat, Ashish Bavdekar, Isaac I Bogoch, John D Clemens, Kesia Esther da Silva, Anuradha De, Joep de Ligt, Paula Lucia Diaz Guevara, Christiane Dolecek, Shanta Dutta, Marthie M Ehlers, Louise Francois Watkins, Denise O Garrett, Gauri Godbole, Melita A Gordon, Andrew R Greenhill, Chelsey Griffin, Madhu Gupta, Rene S Hendriksen, Robert S Heyderman, Yogesh Hooda, Juan Carlos Hormazabal, Odion O Ikhimiukor, Junaid Iqbal, Jobin John Jacob, Claire Jenkins, Dasaratha Ramaiah Jinka, Jacob John, Gagandeep Kang, Abdoulie Kanteh, Arti Kapil, Abhilasha Karkey, Samuel Kariuki, Robert A Kingsley, Roshine Mary Koshy, AC Lauer, Myron M Levine, Ravikumar Kadahalli Lingegowda, Stephen P Luby, Grant Austin Mackenzie, Tapfumanei Mashe, Chisomo Msefula, Ankur Mutreja, Geetha Nagaraj, Savitha Nagaraj, Satheesh Nair, Take K Naseri, Susana Nimarota-Brown, Elisabeth Njamkepo, Iruka N Okeke, Sulochana Putli Bai Perumal, Andrew J Pollard, Agila Kumari Pragasam, Firdausi Qadri, Farah N Qamar, Sadia Isfat Ara Rahman, Savitra Devi Rambocus, David A Rasko, Pallab Ray, Roy Robins-Browne, Temsunaro Rongsen-Chandola, Jean Pierre Rutanga, Samir K Saha, Senjuti Saha, Karnika Saigal, Mohammad Saiful Islam Sajib, Jessica C Seidman, Jivan Shakya, Varun Shamanna, Jayanthi Shastri, Rajeev Shrestha, Sonia Sia, Michael J Sikorski, Ashita Singh, Anthony M Smith, Kaitlin A Tagg, Dipesh Tamrakar, Arif Mohammed Tanmoy, Maria Thomas, Mathew S Thomas, Robert Thomsen, Nicholas R Thomson, Siaosi Tupua, Krista Vaidya, Mary Valcanis, Balaji Veeraraghavan, François-Xavier Weill, Jackie Wright, Gordon Dougan, Silvia Argimón, Jacqueline A Keane, David M Aanensen, Stephen Baker, Kathryn E Holt, Global Typhoid Genomics Consortium Group Authorship

Publikováno v: eLife, Vol 12 (2023)

Background: The Global Typhoid Genomics Consortium was established to bring together the typhoid research community to aggregate and analyse Salmonella enterica serovar Typhi (Typhi) genomic data to inform public health action. This analysis, which m

Externí odkaz: https://doaj.org/article/13a143010eb0443fa36eddce18230371

Diagnostic performance evaluation of hepatitis B e antigen rapid diagnostic tests in Malawi

Autor: Alexander J. Stockdale, Niza M. Silungwe, Isaac Thom Shawa, Benno Kreuels, Melita A. Gordon, Anna Maria Geretti

Publikováno v: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)

Abstract Background The World Health Organization (WHO) has targeted a reduction in viral hepatitis-related mortality by 65% and incidence by 90% by 2030, necessitating enhanced hepatitis B treatment and prevention programmes in low- and middle-incom

Externí odkaz: https://doaj.org/article/0f2fe286896f4308ba8d1d24955d765d