Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Melissa Works"'
Autor:
Susanne M. Steggerda, Mark K. Bennett, Jason Chen, Ethan Emberley, Tony Huang, Julie R. Janes, Weiqun Li, Andrew L. MacKinnon, Amani Makkouk, Gisele Marguier, Peter J. Murray, Silinda Neou, Alison Pan, Francesco Parlati, Mirna L. M. Rodriguez, Lee-Ann Van de Velde, Tracy Wang, Melissa Works, Jing Zhang, Winter Zhang, Matthew I. Gross
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-18 (2017)
Abstract Background Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-argi
Externí odkaz:
https://doaj.org/article/e6521eae41ac406fb6124cdd07cf5f4d
Autor:
Milica Momcilovic, Sean T. Bailey, Jason T. Lee, Michael C. Fishbein, Clara Magyar, Daniel Braas, Thomas Graeber, Nicholas J. Jackson, Johannes Czernin, Ethan Emberley, Matthew Gross, Julie Janes, Andy Mackinnon, Alison Pan, Mirna Rodriguez, Melissa Works, Winter Zhang, Francesco Parlati, Susan Demo, Edward Garon, Kostyantyn Krysan, Tonya C. Walser, Steven M. Dubinett, Saman Sadeghi, Heather R. Christofk, David B. Shackelford
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 601-610 (2017)
Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We tested the small-molecule inhibitor of glutaminase CB-839 in combination with erlotinib on epi
Externí odkaz:
https://doaj.org/article/f0d6faedf9bb47c7a8edcf0f64321391
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 1 shows information about the differential effects of lenalidomide with additional scfvs and the selected scfv at an additional E:T ratio with OPM-2 and RPMI-8226 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d0afc0464e3243fd418c73786778cf
https://doi.org/10.1158/1535-7163.22506366
https://doi.org/10.1158/1535-7163.22506366
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells have shown promising clinical responses in patients with relapsed/refractory multiple myeloma. Lenalidomide, an immunomodulatory drug, potentiates T cell functionality, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec1de428704b5d6bdfb9b182aec9e142
https://doi.org/10.1158/1535-7163.c.6538380.v1
https://doi.org/10.1158/1535-7163.c.6538380.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
anti-BCMA CAR T amino acid sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b406a8728513acff0fe733a8adcb7e7
https://doi.org/10.1158/1535-7163.22506351.v1
https://doi.org/10.1158/1535-7163.22506351.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 4 shows the effects of lenalidomide on CD27, CCR7, CD45RA, and CAR positivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1925681cdee8d90e38f67e48891705e4
https://doi.org/10.1158/1535-7163.22506357.v1
https://doi.org/10.1158/1535-7163.22506357.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 2 shows the effect of lenalidomide on BCMA expression of the cell lines used in the experiments in this manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c42d08c0f6db0e0ef235edfd100324
https://doi.org/10.1158/1535-7163.22506363.v1
https://doi.org/10.1158/1535-7163.22506363.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 3 shows the effect of lenalidomide on cytokine production by anti-BCMA CAR T cells stimulated with BCMA beads for 24 hours.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7b4172afe6d412aa4e8eaacba36b43
https://doi.org/10.1158/1535-7163.22506360.v1
https://doi.org/10.1158/1535-7163.22506360.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ed1b249766c63e611f54d59f8c8051
https://doi.org/10.1158/1535-7163.22506354.v1
https://doi.org/10.1158/1535-7163.22506354.v1
Autor:
Thomas G. Graeber, Matthew I. Gross, Saman Sadeghi, Heather R. Christofk, Johannes Czernin, Clara E. Magyar, Francesco Parlati, Julie Janes, Alison Pan, Ethan D. Emberley, Daniel Braas, Michael C. Fishbein, Mirna Rodriguez, Melissa Works, Edward B. Garon, Sean T. Bailey, Andy Mackinnon, Kostyantyn Krysan, Jason T. Lee, Steven M. Dubinett, David B. Shackelford, Tonya C. Walser, Winter Zhang, Milica Momcilovic, Susan Demo, Nicholas Jackson
Publikováno v:
Cell Reports, Vol 18, Iss 3, Pp 601-610 (2017)
Cell reports, vol 18, iss 3
Cell reports, vol 18, iss 3
Cancer cells exhibit increased use of nutrients, including glucose and glutamine, to support the bioenergetic and biosynthetic demands of proliferation. We tested the small-molecule inhibitor ofglutaminase CB-839 in combination with erlotinib on epid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdddd976408592b503b4350a333c3156
http://www.sciencedirect.com/science/article/pii/S2211124716317685
http://www.sciencedirect.com/science/article/pii/S2211124716317685