Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Melissa V Gammons"'
Publikováno v:
eLife, Vol 9 (2020)
Feedback control is a universal feature of cell signaling pathways. Naked/NKD is a widely conserved feedback regulator of Wnt signaling which controls animal development and tissue homeostasis. Naked/NKD destabilizes Dishevelled, which assembles Wnt
Externí odkaz:
https://doaj.org/article/d6bab8cbc1134dcea1a33a730546eea4
Autor:
Wei Kan, Michael D Enos, Elgin Korkmazhan, Stefan Muennich, Dong-Hua Chen, Melissa V Gammons, Mansi Vasishtha, Mariann Bienz, Alexander R Dunn, Georgios Skiniotis, William I Weis
Publikováno v:
eLife, Vol 9 (2020)
In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector D
Externí odkaz:
https://doaj.org/article/909d22a097d24da0a1d1f2431d614ce4
Autor:
David O Bates, Athina Mavrou, Yan Qiu, James G Carter, Maryam Hamdollah-Zadeh, Shaney Barratt, Melissa V Gammons, Ann B Millar, Andrew H J Salmon, Sebastian Oltean, Steven J Harper
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68399 (2013)
Vascular Endothelial Growth Factor-A (VEGF-A) can be generated as multiple isoforms by alternative splicing. Two families of isoforms have been described in humans, pro-angiogenic isoforms typified by VEGF-A165a, and anti-angiogenic isoforms typified
Externí odkaz:
https://doaj.org/article/c5e11b23554f49f3992873cd602d0d0f
Autor:
Mariann Bienz, Gonzalo J Beitia, Stefan M.V. Freund, Melissa V. Gammons, Hugh R.B. Pelham, Trevor J. Rutherford
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We report a Dishevelled structural clamp, a β-sheet containing a conserved phosphorylation site immediately upstream of the Dishevelled, Egl-10, and Pleckstrin (DEP) domain, contacting a cognate surface on its partner DEP domain to stab
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
Feedback control is a universal feature of cell signaling pathways. Naked/NKD is a widely conserved feedback regulator of Wnt signaling which controls animal development and tissue homeostasis. Naked/NKD destabilizes Dishevelled, which assembles Wnt
Feedback control is a universal feature of cell signaling pathways. Naked/NKD is a widely conserved feedback regulator of Wnt signaling which controls animal development and tissue homeostasis. Naked/NKD destabilizes Dishevelled, which assembles Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19fc48c7c9f9b0f79079e1fe2251fb87
https://doi.org/10.1101/2020.06.10.144725
https://doi.org/10.1101/2020.06.10.144725
Autor:
Melissa V. Gammons, Michael D Enos, Georgios Skiniotis, Mariann Bienz, Alexander R. Dunn, Dong-Hua Chen, Elgin Korkmazhan, Mansi Vasishtha, Wei Kan, Stefan Muennich, William I. Weis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ea2bc860079c4690449fad7f0364f8
https://doi.org/10.7554/elife.55015.sa2
https://doi.org/10.7554/elife.55015.sa2
Autor:
Georgios Skiniotis, Elgin Korkmazhan, Melissa V. Gammons, Michael D Enos, Dong-Hua Chen, Mariann Bienz, William I. Weis, Mansi Vasishtha, Alexander R. Dunn, Wei Kan, Stefan Muennich
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
In Wnt/β-catenin signaling, the transcriptional coactivator β-catenin is regulated by its phosphorylation in a complex that includes the scaffold protein Axin and associated kinases. Wnt binding to its coreceptors activates the cytosolic effector D
Publikováno v:
Molecular Cell
Summary Extracellular signals are often transduced by dynamic signaling complexes (“signalosomes”) assembled by oligomerizing hub proteins following their recruitment to signal-activated transmembrane receptors. A paradigm is the Wnt signalosome,