Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Melissa T. Manners"'
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106610- (2024)
Chronic stress is a major precursor to various neuropsychiatric disorders and is linked with increased inflammation in the brain. However, the bidirectional association between inflammation and chronic stress has yet to be fully understood. Astrocyte
Externí odkaz:
https://doaj.org/article/6f218ef5ce7c46309b457bf48cebb54e
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Opioid drugs have been long known to induce different responses in males compared to females, however, the molecular mechanisms underlying these effects are yet to be fully characterized. Recent studies have established a link between the gut microbi
Externí odkaz:
https://doaj.org/article/c09fb92090544517bc504829a27435f9
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5085 (2024)
The brain is the central organ of adaptation to stress because it perceives and determines threats that induce behavioral, physiological, and molecular responses. In humans, chronic stress manifests as an enduring consistent feeling of pressure and b
Externí odkaz:
https://doaj.org/article/e6a8704c0c7c487ab0865ac3b37ecc44
Publikováno v:
Stress, Vol 26, Iss 1 (2023)
Besides significant benefits to physical health, exercise promotes mental health, reduces symptoms of mental illness, and enhances psychological development. Exercise can offset the impact of chronic stress, which is a major precursor to the developm
Externí odkaz:
https://doaj.org/article/e359eb52266245508b1e5125767c6d21
Publikováno v:
Life, Vol 12, Iss 2, p 196 (2022)
Major depressive disorder is one of the most prevalent mental health disorders. Monoamine-based antidepressants were the first drugs developed to treat major depressive disorder. More recently, ketamine and other analogues were introduced as fast-act
Externí odkaz:
https://doaj.org/article/4ac1a22e015b44018affa15874cdf59d
Publikováno v:
FEBS Open Bio, Vol 5, Iss 1, Pp 733-740 (2015)
Nerve injury induces chronic pain and dysregulation of microRNAs in dorsal root ganglia (DRG). Several downregulated microRNAs are predicted to targetMecp2. MECP2 mutations cause Rett syndrome and these patients report decreased pain perception. We c
Externí odkaz:
https://doaj.org/article/379c826989e6465abc540ca3c3439668
Autor:
Chad E. Beyer, Jason M. Dwyer, Michael J. Piesla, Brian J. Platt, Ru Shen, Zia Rahman, Karen Chan, Melissa T. Manners, Tarek A. Samad, Jeffrey D. Kennedy, Brendan Bingham, Garth T. Whiteside
Publikováno v:
Neurobiology of Disease, Vol 39, Iss 2, Pp 148-155 (2010)
Rimonabant was the first clinically marketed cannabinoid (CB)1 receptor antagonist developed to treat obesity. Unfortunately, CB1 receptor antagonism produced adverse psychiatric events in patients. To determine whether this occurs pre-clinically, we
Externí odkaz:
https://doaj.org/article/076a332ba28d4a31822f0239f65decee
Autor:
Melissa T. Manners, Darrell Eacret, Xin Liu, Max Schechter, Julie A. Blendy, Julia K. Brynildsen
Publikováno v:
Brain Behav Immun
The transcription factor CREB (cyclic AMP response element (CRE)-binding protein) is implicated in the pathophysiology and treatment of depression. Structural and functional studies in both animals and humans suggest that abnormalities of the hippoca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1930f14103791250f2dc6d3546dbd180
https://doi.org/10.1016/j.bbi.2019.06.035
https://doi.org/10.1016/j.bbi.2019.06.035
Autor:
G. R. Grant, Julie A. Blendy, Nicole L. Yohn, Melissa T. Manners, Nicholas F. Lahens, Marisa S. Bartolomei
Publikováno v:
Genes Brain Behav
Adolescent stress can impact health and well-being not only during adulthood of the exposed individual but even in future generations. To investigate the molecular mechanisms underlying these long-term effects, we exposed adolescent males to stress a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e141024ff0e75408678a6c08167f6a6b
https://europepmc.org/articles/PMC6292780/
https://europepmc.org/articles/PMC6292780/
Autor:
Denise Gallagher, Melissa Donigan, Joseph T. Nickels, Florencia Pascual, Melissa T. Manners, Christina Gallo-Ebert, Weiwei Chen, George M. Carman, Robert Swanson, Hsing-Yin Liu, Devanshi Pandya
Publikováno v:
Journal of Biological Chemistry. 288:35466-35477
Saccharomyces cerevisiae ergosterol biosynthesis, like cholesterol biosynthesis in mammals, is regulated at the transcriptional level by a sterol feedback mechanism. Yeast studies defined a 7-bp consensus sterol-response element (SRE) common to genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8c890cc8d5c4b45fc4eec797b7f87f
https://doi.org/10.1074/jbc.m113.526087
https://doi.org/10.1074/jbc.m113.526087