Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Melissa Sykes"'
Autor:
Janet C. Reid, Vicky M. Avery, Lendl Tan, Neda AbuGharbiyeh, Melissa Sykes, Chee Wei Ang, Mark E. Cooper, Mark A. T. Blaskovich, Anjan Debnath, Nicholas P. West
Publikováno v:
Journal of Medicinal Chemistry
Following the approval of delamanid and pretomanid as new drugs to treat drug-resistant tuberculosis, there is now a renewed interest in bicyclic nitroimidazole scaffolds as a source of therapeutics against infectious diseases. We recently described
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc03fe8a19391b7a47f0a5f5f1a60d2e
http://europepmc.org/articles/PMC7770830
http://europepmc.org/articles/PMC7770830
Autor:
Ronald W. Brown, Vicky M. Avery, Melissa Sykes, Paul A. Keller, Ashraf M. Abdel-Megeed, Amy J. Jones, Christopher J. T. Hyland, Jonathan B. Baell, Marcel Kaiser
Publikováno v:
RSC Med Chem
African sleeping sickness is a potentially fatal neglected disease affecting sub-Saharan Africa. High-throughput screening identified the thiazolyl–benzothiophenamide 1 to be active against the causative parasite, Trypanosoma brucei. This work esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a72a8f11e2e7a5222d6d5ed9e132a513
https://doi.org/10.1039/d0md00277a
https://doi.org/10.1039/d0md00277a
Autor:
Amanda G. Eufrasio, Stephanie Russell, Girdhar Singh Deora, Amy J. Jones, Artur T. Cordeiro, Swapna Varghese, Vicky M. Avery, Raphaël Rahmani, Matthew J. Piggott, Lori Ferrins, Arthur Toynton, Julian Sherman, Melissa Sykes, Ana Rodriguez, Albane Kessler, Jonathan B. Baell
Publikováno v:
ACS Med Chem Lett
[Image: see text] Trypanosoma brucei (T. brucei) and Trypanosoma cruzi (T. cruzi) are causative agents of parasitic diseases known as human African trypanosomiasis and Chagas disease, respectively. Together, these diseases affect 68 million people ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f374eb70f63e10320e28ac0dca5f06a
https://doi.org/10.1021/acsmedchemlett.9b00218
https://doi.org/10.1021/acsmedchemlett.9b00218
Autor:
Adam P. Wdowiak, Kirill V. Sukhoverkov, Bilal Zulfiqar, Nicholas P. West, Melissa Sykes, Leonardo Lucantoni, Alexandre N. Sobolev, Glenn A. Pullella, Matthew J. Piggott, Vicky M. Avery, Joshua S. Mylne
Publikováno v:
Organic Letters. 21:5519-5523
The first approaches to the 10′-anthronyl-2-anthraquinone skeleton have been devised, allowing two syntheses of the marine natural product albopunctatone. Both routes involve regioselective addition of a nucleophilic masked anthraquinone to a prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17b1799103da4c261243b5e55e342ea
https://doi.org/10.1021/acs.orglett.9b01838
https://doi.org/10.1021/acs.orglett.9b01838
Autor:
James J. De Voss, G. Paul Savage, Maree T. Smith, Glen M. Boyle, Benjamin A. Chalmers, John Tsanaktsidis, Jeanette E. Stok, Vicky M. Avery, Paul V. Bernhardt, Hui Xing, Melissa Sykes, Craig M. Williams, Sevan D. Houston, Clementina Farfan Soto, Jed M. Burns, Tyler Fahrenhorst-Jones
Publikováno v:
Organic & Biomolecular Chemistry. 17:6790-6798
The cubane phenyl ring bioisostere paradigm was further explored in an extensive study covering a wide range of pharmaceutical and agrochemical templates, which included antibiotics (cefaclor, penicillin G) and antihistamine (diphenhydramine), a smoo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b405b9f46fdced55075c7e77e78dae7
https://doi.org/10.1039/c9ob01238a
https://doi.org/10.1039/c9ob01238a
Autor:
Patrick D. O'Connor, William A. Denny, John M. Kelly, Karen L. White, Vicky M. Avery, Melissa Sykes, Amanda F. Francisco, Scott Cornwall, Andrew J. Marshall, Jennifer Riley, Bilal Zulfiqar, Susan A. Charman, Catherine J. Perez, Kevin D. Read, Eric Chatelain, Andrew M. Thompson, R.C. Andrew Thompson, Martine Keenan
Phenotypic screening of a 900 compound library of antitubercular nitroimidazole derivatives related to pretomanid against the protozoan parasite Trypanosoma cruzi (the causative agent for Chagas disease) identified several structurally diverse hits w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f4d7d9298b453cdb9602cabb875e1e
Publikováno v:
RSC Med Chem
Trypanosoma cruzi and Trypanosoma brucei are the parasitic causative agents of Chagas disease and human African trypanosomiasis (HAT), respectively. The drugs currently used to treat these diseases are not efficacious against all stages and/or parasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f1df8e8ec4f1efc7af58b1c878468c
https://europepmc.org/articles/PMC7578707/
https://europepmc.org/articles/PMC7578707/
Autor:
Angie M. Jarrad, Mark A. T. Blaskovich, Tomislav Karoli, Mark S. Butler, Chee Wei Ang, Nicholas P. West, Mark E. Cooper, Vicky M. Avery, Melissa Sykes, Kyra Woods, Anjan Debnath, Amy J. Jones, Hye Jee Hahn, Lendl Tan, Ruby Pelingon
Publikováno v:
Journal of Medicinal Chemistry
Tuberculosis and parasitic diseases, such as giardiasis, amebiasis, leishmaniasis, and trypanosomiasis, all urgently require improved treatment options. Recently, it has been shown that antitubercular bicyclic nitroimidazoles such as pretomanid and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdeebf31546a59be77d3cad28af05e55
https://doi.org/10.1021/acs.jmedchem.8b01578
https://doi.org/10.1021/acs.jmedchem.8b01578
Autor:
Janis M. Harmon, Melissa Sykes, Kassandra Smith, Karen D. Wood, Kimberly Ramadan, Nauff Zakaria
Publikováno v:
Reading Psychology. 37:962-994
This qualitative study investigated high school reading programs and participants focusing on the insider perspectives of teachers and their students. The study occurred in two sites, one in a Southern state and the other in an Eastern state. The par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efda3faefa4fe07eaafdccb13fca1d2b
https://doi.org/10.1080/02702711.2016.1157536
https://doi.org/10.1080/02702711.2016.1157536
Autor:
Jonathan B. Baell, Emma E. Watson, Marcel Kaiser, Richard J. Payne, Vicky M. Avery, Melissa Sykes, Alexandra Manos-Turvey, Amy J. Jones
Publikováno v:
MedChemComm. 6:403-406
The synthesis and anti-trypanosomal activity of a compound library based on a phenoxymethylbenzamide hit discovered in a high throughput screen is described. Several of the analogues exhibited potent activity against Trypanosoma brucei rhodesiense, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a0831c2ab4e3b35776ffad306cca6b
https://doi.org/10.1039/c4md00406j
https://doi.org/10.1039/c4md00406j