Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Melissa Skibba"'
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Idiopathic Pulmonary Fibrosis (IPF) is a chronically progressive interstitial lung that affects over 3 M people worldwide and rising in incidence. With a median survival of 2–3 years, IPF is consequently associated with high morbidity, mortality, a
Externí odkaz:
https://doaj.org/article/b072f1ad775c40298fba1366ce1650d1
Autor:
Melissa Skibba, Md. Abdul Hye Khan, Lauren L. Kolb, Michael M. Yeboah, John R. Falck, Radhika Amaradhi, John D. Imig
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Renal fibrosis, which is a critical pathophysiological event in chronic kidney diseases, is associated with renal epithelial-to-mesenchymal transition (EMT). Epoxyeicosatrienoic acids (EETs) are Cyp epoxygenase arachidonic acid metabolites that demon
Externí odkaz:
https://doaj.org/article/3c8d726ed4a043b2bd11b29c3926b108
Autor:
Yuanyuan Qian, Peng Zhong, Dandan Liang, Zheng Xu, Melissa Skibba, Chunlai Zeng, Xiaokun Li, Tiemin Wei, Lianpin Wu, Guang Liang
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120215 (2015)
Obesity is strongly associated with the cause of structural and functional changes of the heart in both human and animal models. Oxidative stress and inflammation play a critical role in the development of obesity-induced cardiac disorders. Curcumin
Externí odkaz:
https://doaj.org/article/bea8ac325ea64c0c8fca8377a9fedd85
Publikováno v:
Journal of Diabetes Research, Vol 2013 (2013)
Fibroblast growth factors (FGFs) are classically known as hormonal factors and recent studies have revealed that FGFs have a key role in regulating growth and development of several reproductive organs, including the testis. The testis is mainly cons
Externí odkaz:
https://doaj.org/article/e8d616e33a614f8ba6ea52704b13723b
Autor:
Chi Zhang, Linbo Zhang, Shali Chen, Biao Feng, Xuemian Lu, Yang Bai, Guang Liang, Yi Tan, Minglong Shao, Melissa Skibba, Litai Jin, Xiaokun Li, Subrata Chakrabarti, Lu Cai
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82287 (2013)
BACKGROUND: Emerging evidence showed the beneficial effect of acidic fibroblast growth factor (aFGF) on heart diseases. The present study investigated whether non-mitogenic aFGF (nm-aFGF) can prevent diabetic cardiomyopathy and the underlying mechani
Externí odkaz:
https://doaj.org/article/50230d34132f4e99905d3c874a390939
Genomic targets of the IRE1-XBP1s pathway in mediating metabolic adaptation in epithelial plasticity
Publikováno v:
Nucleic Acids Research. 51:3650-3670
Epithelial mesenchymal plasticity (EMP) is a complex cellular reprogramming event that plays a major role in tissue homeostasis. Recently we observed the unfolded protein response (UPR) triggers EMP through the inositol-requiring protein 1 (IRE1α)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38ed55319c1df2f7098b41821e8043f8
https://doi.org/10.1093/nar/gkad077
https://doi.org/10.1093/nar/gkad077
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 16; Pages: 9000
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections (LRTI) associated with decreased pulmonary function, asthma, and allergy. Recently, we demonstrated that RSV induces the hexosamine biosynthetic pathway via the unfold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fb4c57c9ca4425e3df030f9a1c6bcd
Autor:
Ksenija Bernau, Melissa Skibba, Jonathan P. Leet, Sierra Furey, Carson Gehl, Yi Li, Jia Zhou, Nathan Sandbo, Allan R. Brasier
Publikováno v:
Frontiers in Molecular Medicine. 2
Idiopathic pulmonary fibrosis is a lethal disease driven by myofibroblast expansion. Currently no therapies exist that target the epigenetic mechanisms controlling myofibroblast transdifferentiation, which is responsible for unregulated extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cda01156d3e95cc8cf10830327a8457
https://doi.org/10.3389/fmmed.2022.842558
https://doi.org/10.3389/fmmed.2022.842558
Autor:
Roberto P. Garofalo, Melissa Skibba, Xiaofang Xu, Dianhua Qiao, Yingxin Zhao, Allan R. Brasier
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 321(3)
The paramyxoviridae, respiratory syncytial virus (RSV), and murine respirovirus are enveloped, negative-sense RNA viruses that are the etiological agents of vertebrate lower respiratory tract infections (LRTIs). We observed that RSV infection in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b13b0d9073cbe898c9d9fe4c8978c2d
https://pubmed.ncbi.nlm.nih.gov/34318710
https://pubmed.ncbi.nlm.nih.gov/34318710
Autor:
Lauren L. Kolb, René Blöcher, Markus Hartmann, Abdul H. Khan, John D. Imig, Melissa Skibba, Ewgenij Proschak
Publikováno v:
Diabetologia. 61:2235-2246
AIMS/HYPOTHESIS: The metabolic syndrome is a cluster of risk correlates that can progress to type 2 diabetes. The present study aims to evaluate a novel molecule with a dual action against the metabolic syndrome and type 2 diabetes. METHODS: We devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da198171413c6378eb813ed70bf5aef
https://doi.org/10.1007/s00125-018-4685-0
https://doi.org/10.1007/s00125-018-4685-0