Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Melissa Scholefield"'
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
BackgroundDementia with Lewy bodies (DLB) can be difficult to distinguish from Alzheimer’s disease (AD) and Parkinson’s disease dementia (PDD) at different stages of its progression due to some overlaps in the clinical and neuropathological prese
Externí odkaz:
https://doaj.org/article/dc0b770d0c4c4f41a9adf842be695bbb
Autor:
Melissa Scholefield, Stephanie J. Church, George Taylor, David Knight, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
npj Parkinson's Disease, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, most commonly characterised by motor dysfunction, but also with a high prevalence of cognitive decline in the decades following diagnosis—a condition known as
Externí odkaz:
https://doaj.org/article/f02d70b9f7a349db9090cc49b4e80243
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionVascular dementia (VaD) is one of the most common causes of dementia among the elderly. Despite this, the molecular basis of VaD remains poorly characterized when compared to other age-related dementias. Pervasive cerebral elevations of u
Externí odkaz:
https://doaj.org/article/7512390f6448457da5107a8761bc0857
Autor:
Sasha A. Philbert, Jingshu Xu, Melissa Scholefield, Stephanie J. Church, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Vascular dementia (VaD) is thought to be the second most common cause of age-related dementia amongst the elderly. However, at present, there are no available disease-modifying therapies for VaD, probably due to insufficient understanding about the m
Externí odkaz:
https://doaj.org/article/39efd04749634e7b828ce0cb6c4e5f5b
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Widespread elevations in brain urea have, in recent years, been reported in certain types of age-related dementia, notably Alzheimer’s disease (AD) and Huntington’s disease (HD). Urea increases in these diseases are substantive, and approximate i
Externí odkaz:
https://doaj.org/article/19001ef99efe4d14957c087415473dbc
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Several studies of Parkinson's disease (PD) have reported dysregulation of cerebral metals, particularly decreases in copper and increases in iron in substantia nigra (SN). However, few studies have investigated regions outside the SN, fewer have mea
Externí odkaz:
https://doaj.org/article/c771a8427ef54805a19961581ac0aefb
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Stefano Patassini, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Metabolites, Vol 11, Iss 9, p 569 (2021)
Pantothenic acid (vitamin B5) is an essential trace nutrient required for the synthesis of coenzyme A (CoA). It has previously been shown that pantothenic acid is significantly decreased in multiple brain regions in both Alzheimer’s disease (ADD) a
Externí odkaz:
https://doaj.org/article/c478ab4f1e094e158574b5baa876cff0
Autor:
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Andrew C. Robinson, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Publikováno v:
Metabolites, Vol 10, Iss 11, p 438 (2020)
The use of post-mortem human tissue is indispensable in studies investigating alterations in metabolite levels in neurodegenerative conditions such as Alzheimer’s disease (AD). However, variability between samples may have unknown effects on metabo
Externí odkaz:
https://doaj.org/article/bd6bf168e484432ab371cc420f223056
Autor:
Sasha Philbert, Jingshu Xu, Melissa Scholefield, Stefano Patassini, Stephanie J. Church, Richard D. Unwin, Federico Roncaroli, Garth J.S. Cooper
Vascular dementia (VaD) is one of the most common causes of dementia amongst the elderly. Despite this, the molecular basis of VaD remains poorly characterised when compared to other age-related dementias. Probably as a result, therapeutic options ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4803bd8715a09260f9324edafffcf6c4
https://doi.org/10.21203/rs.3.rs-1670831/v1
https://doi.org/10.21203/rs.3.rs-1670831/v1
Autor:
Jingshu Xu, Natalie J. Gardiner, Melissa Scholefield, Garth J. S. Cooper, Nigel M. Hooper, Stephanie J. Church, Sarah Kassab, Richard D. Unwin, Federico Roncaroli
Publikováno v:
Scholefield, M, Church, S J, Xu, J, Kassab, S, Gardiner, N J, Roncaroli, F, Hooper, N M, Unwin, R D & Cooper, G J S 2020, ' Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location ', Metallomics : integrated biometal science . https://doi.org/10.1039/d0mt00048e
Studies of neurodegenerative conditions such as Alzheimer’s disease (AD) using post mortem brain tissues have uncovered several perturbations in metals such as copper, iron, and zinc. However, studies of the effects of key, potentially confounding