Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Melissa Samuel"'
Autor:
George C. Gabriel, William A. Devine, Bethany K. Redel, Kristin M. Whitworth, Melissa Samuel, Lee D. Spate, Raissa F. Cecil, Randall S. Prather, Yijen L. Wu, Kevin D. Wells, Cecilia W. Lo
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The pig is an ideal model system for studying human development and disease due to its similarities to human anatomy, physiology, size, and genome. Further, advances in CRISPR gene editing have made genetically engineered pigs viable models
Externí odkaz:
https://doaj.org/article/93f422a95d7043129581d1f40224dc7b
Autor:
Lynda S Ostedgaard, Margaret P Price, Kristin M Whitworth, Mahmoud H Abou Alaiwa, Anthony J Fischer, Akshaya Warrier, Melissa Samuel, Lee D Spate, Patrick D Allen, Brieanna M Hilkin, Guillermo S Romano Ibarra, Miguel E Ortiz Bezara, Brian J Goodell, Steven E Mather, Linda S Powers, Mallory R Stroik, Nicholas D Gansemer, Camilla E Hippee, Keyan Zarei, J Adam Goeken, Thomas R Businga, Eric A Hoffman, David K Meyerholz, Randall S Prather, David A Stoltz, Michael J Welsh
Publikováno v:
eLife, Vol 9 (2020)
Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous airways. Although it has been assumed that SMGs contribute to respiratory defense, that hypothesis has gone without a direct test. Therefore, we studied pigs, which hav
Externí odkaz:
https://doaj.org/article/de4e52b4b350483bb95240e3006ac61e
Autor:
Jing Yang, Steven Menges, Ping Gu, Ronald Tongbai, Melissa Samuel, Randall S. Prather, Henry Klassen
Publikováno v:
Cell Transplantation, Vol 26 (2017)
The impact of gestational age on mammalian neural progenitor cells is potentially important for both an understanding of neural development and the selection of donor cells for novel cell-based treatment strategies. In terms of the latter, it can be
Externí odkaz:
https://doaj.org/article/3104af9f82e5410cb6a6d1f66c08c0a1
Autor:
Erek Nelson, Fang Jin, Taofic Mounajjed, Yao Jia, Wei Zhou, Raymond D. Hickey, Aaron J. Johnson, Bruce Amiot, Scott L. Nyberg, Randall S. Prather, Adam J. Wood, Anna Spate, Dong Jin Joo, Min Shi, Kevin D. Wells, Anna Minshew, Ellen L. Larson, Joeseph Lillegard, Piero Rinaldo, Anan Abu Rmilah, Eric M. Walters, Jeffrey L. Platt, Melanie C. Bois, Melissa Samuel, Jaime Glorioso, Kristin M. Whitworth, Shennen A. Mao
Publikováno v:
Tissue Engineering Part A. 28:150-160
The mammalian liver's regenerative ability has led researchers to engineer animals as incubators for expansion of human hepatocytes. The expansion properties of human hepatocytes in immunodeficient...
Autor:
Melissa Samuel, Caroline A Pfeiffer, Destiny N Johns, Matthew C. Lucy, Kevin D. Wells, Melissa A Fudge, Lee D. Spate, Hongyu Liu, Shelbi D Perry, Caroline G Lucas, Paula R Chen, Christine Spinka, Rodney D. Geisert, Thomas E. Spencer, Raissa F. Cecil, Randall S. Prather, Ashley E Meyer
Publikováno v:
Biology of Reproduction. 105:1577-1590
Establishment and maintenance of pregnancy in the pig is a complex process that relies on conceptus regulation of the maternal proinflammatory response to endometrial attachment. Following elongation, pig conceptuses secrete interferon gamma (IFNG) d
Autor:
Paula R Chen, Randall S. Prather, Joshua A. Benne, Lee D. Spate, Taylor K. Hord, Raissa F. Cecil, Melissa Samuel
Publikováno v:
Molecular Reproduction and Development
To improve efficiency of somatic cell nuclear transfer (SCNT), it is necessary to modify differentiated donor cells to become more amendable for reprogramming by the oocyte cytoplasm. A key feature that distinguishes somatic/differentiated cells from
Autor:
Erek David, Nelson, Ellen, Larson, Dong Jin, Joo, Shennen, Mao, Jaime, Glorioso, Anan, Abu Rmilah, Wei, Zhou, Yao, Jia, Taofic, Mounajjed, Min, Shi, Melanie, Bois, Adam, Wood, Fang, Jin, Kristin, Whitworth, Kevin, Wells, Anna, Spate, Melissa, Samuel, Anna, Minshew, Eric, Walters, Piero, Rinaldo, Joseph B, Lillegard, Aaron, Johnson, Bruce, Amiot, Raymond, Hickey, Randall, Prather, Jeffrey L, Platt, Scott L, Nyberg
Publikováno v:
Tissue engineering. Part A. 28(3-4)
The mammalian liver's regenerative ability has led researchers to engineer animals as incubators for expansion of human hepatocytes. The expansion properties of human hepatocytes in immunodeficient mice are well known. However, little has been report
Autor:
Randall S. Prather, Bethany K. Redel, Cecilia W. Lo, William A. Devine, Yijen L. Wu, Melissa Samuel, Kevin D. Wells, Raissa F. Cecil, Lee D. Spate, Kristin M. Whitworth, George C. Gabriel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Modeling cardiovascular diseases in mice has provided invaluable insights into the cause of congenital heart disease. However, the small size of the mouse heart has precluded translational studies. Given current high‐efficiency gene edit
Autor:
Thomas E. Spencer, Michael F. Smith, Megan K McLean, Melissa Samuel, Ashley E Meyer, Joshua A. Benne, Clifton N. Murphy, Lee D. Spate, Rodney D. Geisert, Caroline A Pfeiffer, Kevin D. Wells, Raissa F. Cecil, Susanta K. Behura, Randall S. Prather, Lauren A Ciernia, Kelsey E. Brooks, Kristin M. Whitworth
Publikováno v:
Biology of Reproduction. 101:148-161
The proposed signal for maternal recognition of pregnancy in pigs is estrogen (E2), produced by the elongating conceptuses between days 11 to 12 of pregnancy with a more sustained increase during conceptus attachment and placental development on days
Autor:
Melissa Samuel, Kevin D. Wells, Bethany R. Mordhorst, Kristin M. Whitworth, Raissa F. Cecil, Lee D. Spate, Jonathan A. Green, Clifton N. Murphy, Randall S. Prather, Joshua A. Benne
Publikováno v:
Molecular Reproduction and Development
Genetically engineered pigs serve as excellent biomedical and agricultural models. To date, the most reliable way to generate genetically engineered pigs is via somatic cell nuclear transfer (SCNT), however, the efficiency of cloning in pigs is low (