Výsledky vyhledávání - "Melissa S. Wason"

Cerium Oxide Nanoparticles Sensitize Pancreatic Cancer to Radiation Therapy through Oxidative Activation of the JNK Apoptotic Pathway

Autor: Debarati Mukherjee, Heng Lu, Lin Yu, Chao Shen, Melissa S. Wason, Satadru K. Lahiri, Jihe Zhao, Sudipta Seal, Soumen Das

Publikováno v: Cancers
Volume 10
Issue 9
Cancers, Vol 10, Iss 9, p 303 (2018)

Side effects of radiation therapy (RT) remain the most challenging issue for pancreatic cancer treatment. Cerium oxide nanoparticles (CONPs) are currently being tested in pre-clinical trials as an adjuvant to sensitize pancreatic cancer cells to RT a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8249f2888cdaa3902284b24b4304587a
https://pubmed.ncbi.nlm.nih.gov/30200491

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Synthesis and Biological Evaluation of Antimetastatic Agents Predicated upon Dihydromotuporamine C and Its Carbocyclic Derivatives

Autor: Teresa R. Johnson, Aaron Muth, Melissa S. Wason, Cheryl H. Baker, Xianlin Han, Deborah A. Altomare, Navneet Kaur, Veethika Pandey, Otto Phanstiel

Publikováno v: Journal of Medicinal Chemistry. 57:4023-4034

The motuporamines isolated from the sea sponge Xestospongia exigua are of biological interest because of their unique antimigration and antiangiogenic properties. Key bioactive features were found to be a saturated 15-membered heterocycle and a norsp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73856a7a98c08935cada35133cfdc4c
https://doi.org/10.1021/jm401906v

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Identification of epithelial stromal interaction 1 as a novel effector downstream of Krüppel-like factor 8 in breast cancer invasion and metastasis

Autor: Debarati Mukherjee, Lin Yu, Chao Shen, Satadru K. Lahiri, Jihe Zhao, Tianshu Li, Melissa S. Wason, Heng Lu

Publikováno v: Oncogene

Krüppel-like factor 8 (KLF8) is a transcriptional factor critical for metastatic progression of breast cancer. Epithelial stromal interaction 1 (EPSTI1), a recently identified stromal fibroblast-induced gene in non-invasive breast cancer cells is hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebe2219f2d8d8c663d6603ef39612864
http://europepmc.org/articles/PMC3979502

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KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer

Autor: Debarati Mukherjee, Lin Yu, Jihe Zhao, Liu Hu, Xianhui Wang, Tianshu Li, Chao Shen, Alison M. Urvalek, Heng Lu, Melissa S. Wason, Satadru K. Lahiri

Publikováno v: Oncogene

Krüppel-like factor 8 (KLF8) regulates critical gene transcription associated with cancer. The underlying mechanisms, however, remain largely unidentified. We have recently demonstrated that KLF8 expression enhances the activity but not expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef570d54fa8484f9f22814e7eb5c345a
http://europepmc.org/articles/PMC3929536

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Sensitization of pancreatic cancer cells to radiation by cerium oxide nanoparticle-induced ROS production

Autor: Sudipta Seal, Soumen Das, Jimmie Colon, Cheryl H. Baker, Melissa S. Wason, James Turkson, Jihe Zhao

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 9:558-569

Side effect of radiation therapy (RT) remains the most challenging issue for pancreatic cancer treatment. In this report we determined whether and how cerium oxide nanoparticles (CONPs) sensitize pancreatic cancer cells to RT. CONP pretreatment enhan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff27ce3b988a28c15461baf8d21cd49
https://doi.org/10.1016/j.nano.2012.10.010

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Harnessing nanoparticles to improve toxicity after head and neck radiation

Autor: Rafael Madero-Visbal, Beatrice Alvarado, Jimmie Colon, Melissa S. Wason, Beth Isley, Cheryl H. Baker, R. Manon, Chris M. Lee, Sudipta Seal, Soumen Das

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine. 8:1223-1231

This article reports the evaluation of cerium oxide (CeO 2 ) nanoparticles' ability to decrease xerostomia and radiation-induced dermatitis in mice after head and neck radiation. Mice were irradiated using an IC160 x-ray system. Two cohorts were incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fdd918f9ec25bb73fa2c34da417459
https://doi.org/10.1016/j.nano.2011.12.011

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A Novel Role of Krüppel-like Factor 8 in DNA Repair in Breast Cancer Cells*

Autor: Chao Shen, Hui Xie, Melissa S. Wason, Liu Hu, Heng Lu, Lin Yu, Tianshu Li, Satadru K. Lahiri, Debarati Mukherjee, Jihe Zhao

Krüppel-like factor 8 (KLF8) regulates critical gene transcription and cellular events associated with cancer. However, the role of KLF8 in cancer remains largely unknown. Here, we report a surprisingly novel role for KLF8 in DNA repair in breast ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::282a6e3bfe1ce49aabcb99c66489f06d
https://europepmc.org/articles/PMC3527957/

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Abstract 2687: Krüppel-like factor 8 targets matrix metalloproteinase-14 to promote breast cancer invasion and metastasis

Autor: Chao Shen, Satadru K. Lahiri, Debarati Mukherjee, Heng Lu, Lin Yu, Tianshu Li, Xianhui Wang, Liu Hu, Jihe Zhao, Melissa S. Wason

Publikováno v: Cancer Research. 73:2687-2687

Krüppel-like factor 8 (KLF8) regulates critical gene transcription and invasion events associated with cancer, including epithelial to mesenchymal transition (EMT) and extracellular matrix degradation. Here, we report a novel KLF8-to- matrix metall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::93510a268ddbe96a5ee5ed21fd2263ce
https://doi.org/10.1158/1538-7445.am2013-2687

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Abstract 1468: Cerium oxide nanoparticles sensitize pancreatic cancer cells to radiation by modulating the JNK pathway

Autor: Melissa S. Wason, Jimmie Colon, Cheryl H. Baker, Jihe Zhao

Publikováno v: Cancer Research. 72:1468-1468

Pancreatic cancer, one of the most lethal cancers, has a poor prognosis and a high mortality rate. Currently, the absence of effective therapies increases reliance on radiation therapy (RT) to treat pancreatic cancer. We have previously reported that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dafa2f68e2ae600de81364d8c5c507ab
https://doi.org/10.1158/1538-7445.am2012-1468

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Abstract 2129: Regulation of DNA repair by Kruppel-like factor 8

Autor: Liu Hu, Tianshu Li, and Jihe Zhao, Debarati Mukherjee, Heng Lu, Melissa S. Wason, Satadru K. Lahiri, Lin Yu

Publikováno v: Cancer Research. 72:2129-2129

Krüppel-like factor 8 (KLF8) regulates critical gene transcription and cellular events associated with cancer. Recently we have identified poly(ADP-ribose) polymerase-1(PARP-1) as a novel KLF8-interacting and regulating protein. However, whether KL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2140784beb548d981032189e5065b3bc
https://doi.org/10.1158/1538-7445.am2012-2129

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