Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Melissa S. Jurica"'
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258551 (2021)
U2 snRNP is an essential component of the spliceosome. It is responsible for branch point recognition in the spliceosome A-complex via base-pairing of U2 snRNA with an intron to form the branch helix. Small molecule inhibitors target the SF3B compone
Externí odkaz:
https://doaj.org/article/0976836617604d699a0dbbe03cebfff0
Autor:
Srinivasa Rao Allu, Adriana Gamboa Lopez, Hannah M. Maul-Newby, Guddeti Chandrashekar Reddy, Melissa S. Jurica, Patricia Mendez, Arun K. Ghosh
Publikováno v:
ACS chemical biology, vol 16, iss 3
ACS Chem Biol
ACS Chem Biol
Small molecules that target the spliceosome SF3B complex are potent inhibitors of cancer cell growth. The compounds affect an early stage of spliceosome assembly when U2 snRNP first engages the branch point sequence of an intron. Employing an inactiv
Autor:
Beth E. Prichard, Turvi Sharma, Angela N. Amorello, Matthew S. Modena, John H. Kim, Melissa S. Jurica, Hannah M. Maul-Newby
Publikováno v:
RNA (New York, N.Y.), vol 28, iss 4
A critical step of pre-mRNA splicing is the recruitment of U2 snRNP to the branch point sequence of an intron. U2 snRNP conformation changes extensively during branch helix formation and several RNA-dependent-ATPases are implicated in the process. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5461614442075a3f0d7068f8715446ef
https://escholarship.org/uc/item/00t5w11g
https://escholarship.org/uc/item/00t5w11g
Autor:
Mary J. Pulvino, Zackary Falls, Matthew J. Walter, Rakesh Chatrikhi, Andrew J. MacRae, Jermaine L. Jenkins, Callen F. Feeney, Clara L. Kielkopf, Melissa S. Jurica, William W. Brennessel, Sumit Rai, Georgios Alachouzos, Alison J. Frontier, Timothy A. Graubert, Ram Samudrala
Publikováno v:
Cell chemical biology, vol 28, iss 8
Cell Chem Biol
Cell Chem Biol
Dysregulated pre-mRNA splicing is an emerging Achilles heel of cancers and myelodysplasias. To expand the currently limited portfolio of small molecule drug leads, we screened for chemical modulators of the U2AF complex, which nucleates spliceosome a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895a2cf142ec23caeae71ba14975f65e
https://escholarship.org/uc/item/2sk8s5gr
https://escholarship.org/uc/item/2sk8s5gr
Publikováno v:
PLoS ONE
PloS one, vol 16, iss 10
PLoS ONE, Vol 16, Iss 10, p e0258551 (2021)
PloS one, vol 16, iss 10
PLoS ONE, Vol 16, Iss 10, p e0258551 (2021)
U2 snRNP is an essential component of the spliceosome. It is responsible for branch point recognition in the spliceosome A-complex via base-pairing of U2 snRNA with an intron to form the branch helix. Small molecule inhibitors target the SF3B compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9aab736b989090d4a66e9f1cd9455f7
https://doi.org/10.1101/2021.07.05.451154
https://doi.org/10.1101/2021.07.05.451154
Autor:
Nicholas A. Larsen, Xiang Liu, Patricia Gee, Andrew Cook, Constantin Cretu, Melissa S. Jurica, Vladimir Pena, Anant A. Agrawal, Tuong-Vi Nguyen, Arun K. Ghosh
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Intron selection during the formation of prespliceosomes is a critical event in pre-mRNA splicing. Chemical modulation of intron selection has emerged as a route for cancer therapy. Splicing modulators alter the splicing patterns in cells by binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425751521a803c9bd864ce99295a846
https://escholarship.org/uc/item/3sr415kn
https://escholarship.org/uc/item/3sr415kn
Publikováno v:
J Nat Prod
Journal of natural products, vol 84, iss 5
Journal of natural products, vol 84, iss 5
Spliceostatins and thailanstatins are intriguing natural products due to their structural features as well as their biological significance. This family of natural products has been the subject of immense synthetic interest because they exhibit very
Autor:
Julia Pinheiro Chagas da Cunha, Carla C. Oliveira, Guilherme H. Gatti da Silva, Patricia P. Coltri, Melissa S. Jurica
Publikováno v:
Journal of Cellular Biochemistry. 120:8764-8774
Pre-messenger RNA (mRNA) splicing is an essential step in the control of eukaryotic gene expression. During splicing, the introns are removed from the gene transcripts as the exons are ligated to create mature mRNA sequences. Splicing is performed by
Publikováno v:
PLoS Biology, Vol 11, Iss 8, p e1001621 (2013)
The number of mRNA and protein molecules expressed from a single gene molecule fluctuates over time. These fluctuations have been attributed, in part, to the random transitioning of promoters between transcriptionally active and inactive states, caus
Externí odkaz:
https://doaj.org/article/62f4973d25724669b7cafb93aa7e0d7e
Publikováno v:
J Org Chem
An efficient palladium-free Stille cross-coupling reaction of allylic bromides and functionalized organostannylfuran using catalytic copper halide has been developed. The coupling reaction was optimized using CuI and low catalyst loading (down to 5 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d685f87bb74ad04265d038c71b0f1fd
https://europepmc.org/articles/PMC7900942/
https://europepmc.org/articles/PMC7900942/