Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Melissa S. Egbertson"'
Publikováno v:
Current Topics in Medicinal Chemistry. 7:1251-1272
Replication of the human immunodeficiency virus (HIV) is dependent upon the enzyme HIV integrase (IN), one of three essential enzymes encoded in the viral genome. HIV-1 IN catalyzes the insertion of the proviral DNA into the host genome (strand trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12184cc1172ac48ea4af28676fae76c5
https://doi.org/10.2174/156802607781212248
https://doi.org/10.2174/156802607781212248
Autor:
Thomayant Prueksaritanont, Jerome H. Hochman, Samuel L. Graham, Yuhsin Kuo, Joan D. Ellis, Maria S. Michener, Melissa S. Egbertson, Cuyue Tang, Nicole T. Pudvah, Jacquelynn J. Cook
Publikováno v:
Biochemical Pharmacology. 78:642-647
Brain penetration of drugs which are subject to P-glycoprotein (Pgp)-mediated efflux is attenuated, as manifested by the fact that the cerebrospinal fluid concentration ( C CSF ), a good surrogate of the unbound brain concentration ( C ub ), is lower
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55a1233d36cf396705a799dd7594119
https://doi.org/10.1016/j.bcp.2009.05.026
https://doi.org/10.1016/j.bcp.2009.05.026
Publikováno v:
Synthetic Communications. 37:1887-1897
Practical syntheses of 4‐fluoro‐2‐(methylthio)benzylamine 1 and the corresponding 2‐methylsulfonyl analog 2 are reported. The methylthio moiety was introduced regioselectively by two methods. In the first method, metallation of 4‐fluoro‐2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cba871bc41c1f6391d993ea9f2c74b05
https://doi.org/10.1080/00397910701319221
https://doi.org/10.1080/00397910701319221
Autor:
Gail Murphy, Joseph J. Lynch, Lawrence I. Deckelbaum, Frederick L. Sax and, George D. Hartman, Man-Wai Lo, Melissa S. Egbertson, Robert J. Gould, Eliav Barr, Wasyl Halczenko, Jacquelynn J. Cook, Bohumil Bednar, Mark E. Duggan
Publikováno v:
Cardiovascular Drug Reviews. 17:199-224
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c80cee48cfb05b00fd056a4f28f28da4
https://doi.org/10.1111/j.1527-3466.1999.tb00015.x
https://doi.org/10.1111/j.1527-3466.1999.tb00015.x
Autor:
Melissa S. Egbertson, Marc V. Witmer, Linghang Zhuang, James P. Guare, William A. Schleif, Abigail Wolfe, Payne Linda S, Peter J. Felock, Stuart R. Michelson, Daria J. Hazuda, Steven D. Young, John S. Wai, Joseph J. Lynch, Kara A. Stillmock, Joseph P. Vacca, Lori J. Gabryelski, Yvonne M. Leonard, Mark Embrey, Thorsten E. Fisher, Gregory Moyer
Publikováno v:
Journal of Medicinal Chemistry. 46:453-456
Naphthyridine 7 inhibits the strand transfer of the integration process catalyzed by integrase with an IC50 of 10 nM and inhibits 95% of the spread of HIV-1 infection in cell culture at 0.39 microM. It does not exhibit cytotoxicity in cell culture at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57954f828de9dea836bb7bbeec94991b
https://doi.org/10.1021/jm025553u
https://doi.org/10.1021/jm025553u
Autor:
Keith W. Rickert, Ming-Tain Lai, Daniel Riley, Melissa S. Egbertson, Mike T. Rudd, Kausik K. Nanda, Barbara Hanney, Shawn J. Stachel, Stephanie A. Kane, Jay A. Grobler, Ahren Iver Green, John M. Sanders, Christopher Daley, Paul Zuck, Vandna Munshi, Edward J. Brnardic, Kristen G. Jones, Darrell A. Henze, Alicja Krasowska-Zoladek, Hua-Poo Su, Mark T. Bilodeau, Yiwei Li, Dennis Murphy, Michael D. Leitl, Peter J. Manley
Publikováno v:
Journal of medicinal chemistry. 57(13)
We have identified several series of small molecule inhibitors of TrkA with unique binding modes. The starting leads were chosen to maximize the structural and binding mode diversity derived from a high throughput screen of our internal compound coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b2952fd189ba1bbae53dd14909b8f9
https://pubmed.ncbi.nlm.nih.gov/24914455
https://pubmed.ncbi.nlm.nih.gov/24914455
Autor:
Bohumil Bednar, Patricia A. McQueney, Michael E. Cunningham, Rodney A. Bednar, B. C. Askew, George D. Hartman, Melissa S. Egbertson, Robert J. Gould
Publikováno v:
Cytometry. 28:58-65
Antagonists of platelet glycoprotein IIb/IIIa (GPIIb/IIIa) represent a new therapeutic approach in inhibiting platelet aggregation, thus providing a powerful form of antithrombotic therapy. The measurement of binding of arginine-glycine-aspartic acid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdf8137ec52f60cecd5fdb7c406951e
https://doi.org/10.1002/(sici)1097-0320(19970501)28:1<58::aid-cyto7>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19970501)28:1<58::aid-cyto7>3.0.co
Autor:
R. J. Lynch, Rodney A. Bednar, Bohumil Bednar, Jacquelynn J. Cook, L.M. Vassallo, Marie A. Holahan, Stanley L. Gaul, Melissa S. Egbertson, Laura A. Libby, G. R. Sitko, Robert J. Gould, J.J. Lynch, George D. Hartman, Maria T. Stranieri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2519-2524
Potency enhancing features of two series of fibrinogen receptor antagonists were combined to give analogs with improved potency and oral activity. Antagonists containing either alkyl or aryl sulfonamides and a central isoindolinone structural constra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72ca48d34bf7bd0c8173abb3a1aecb0f
https://doi.org/10.1016/0960-894x(96)00473-8
https://doi.org/10.1016/0960-894x(96)00473-8
Autor:
Melissa S. Egbertson, Jeffrey A. Vivian, Vanita Puri, Jason M. Uslaner, Christopher E. Cannon, Donnie Eddins
Publikováno v:
Neuropharmacology. 64
The cognitive deficits associated with schizophrenia are recognized as a core component of the disorder, yet there remain no available therapeutics to treat these symptoms of the disease. As a result, there is a need for establishing predictive precl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0882164cd2cd07979d0738a1ccd14d
https://pubmed.ncbi.nlm.nih.gov/22659472
https://pubmed.ncbi.nlm.nih.gov/22659472
Autor:
Robert J. Gould, Marie A. Holahan, J.J. Lynch, R. J. Lynch, Maria T. Stranieri, Melissa S. Egbertson, A.M. Naylor, George D. Hartman, Jacquelynn J. Cook, L.M. Vassallo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:1835-1840
Analysis of platelet aggregation inhibition results and rotational isomer preferences has provided an understanding of inhibitory potency for m-phthalic acid analogs 7–7. Constraint of the N-terminal amide led to compound 9, which is potent, select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c138a69e5e62a0b8d357f88db917efaf
https://doi.org/10.1016/s0960-894x(01)80380-2
https://doi.org/10.1016/s0960-894x(01)80380-2