Výsledky vyhledávání - "Melissa S Samuel"

Akademický článek

Serologic titers to Leptospira in vaccinated pigs and interpretation for surveillance.

Autor: Susan K Schommer, Nicholas Harrison, Michael Linville, Melissa S Samuel, Sabrina L Hammond, Kevin D Wells, Randall S Prather

Publikováno v: PLoS ONE, Vol 16, Iss 11, p e0260052 (2021)

Diagnosis and surveillance of pathogenic Leptospira is difficult as organisms may be intermittently shed and in small numbers. Therefore, serologic testing by the microscopic agglutination test (MAT) is the primary screening method for leptospirosis.

Externí odkaz: https://doaj.org/article/47514bb767cf4399856b4d9f491022f2

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Akademický článek

Oral fluid testing can be used to monitor xenotransplant donor herds for porcine cytomegalovirus/roseolovirus status

Autor: Susan K. Schommer, Melissa S. Samuel, Kristin M. Whitworth, Addison K. Byrne, Kevin D. Wells, Randall S. Prather

Publikováno v: Frontiers in Veterinary Science, Vol 11 (2024)

A major concern of xenotransplantation is that donor organs may be a source of pathogens. One pathogen in particular, porcine cytomegalovirus (PCMV), a porcine roseolovirus (PRV), is thought to result in donor organ failure in an immunosuppressed sta

Externí odkaz: https://doaj.org/article/d914359dafc74ef8901f3522a2e07bb2

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Akademický článek

Disruption of Mitochondrion-To-Nucleus Interaction in Deceased Cloned Piglets.

Autor: Joonghoon Park, Liangxue Lai, Melissa S Samuel, David Wax, Randall S Prather, Xiuchun Tian

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129378 (2015)

Most animals produced by somatic cell nuclear transfer (SCNT) are heteroplasmic for mitochondrial DNA (mtDNA). Oxidative phosphorylation (OXPHOS) in clones therefore requires the coordinated expression of genes encoded by the nuclear DNA and the two

Externí odkaz: https://doaj.org/article/801ee70e1e9140ff9fbc862dadbafa76

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Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model

Autor: Shamus P. Keeler, Jennifer Yantis, Benjamin J. Gerovac, Samuel L. Youkilis, Stephanie Podgorny, Dailing Mao, Yong Zhang, Kristin M. Whitworth, Bethany Redel, Melissa S. Samuel, Kevin D. Wells, Randall S. Prather, Michael J. Holtzman

Publikováno v: Am J Physiol Lung Cell Mol Physiol

Morbidity and mortality of respiratory diseases are linked to airway obstruction by mucus but there are still no specific, safe, and effective drugs to correct this phenotype. The need for better treatment requires a new understanding of the basis fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b94d469409d87497a9fac037ed67bc26
https://europepmc.org/articles/PMC9142155/

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Disruption of anthrax toxin receptor 1 in pigs leads to a rare disease phenotype and protection from senecavirus A infection

Publikováno v: Scientific reports. 12(1)

Senecavirus A (SVA) is a cause of vesicular disease in pigs, and infection rates are rising within the swine industry. Recently, anthrax toxin receptor 1 (ANTXR1) was revealed as the receptor for SVA in human cells. Herein, the role of ANTXR1 as a re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e22fcc6361fa29d91ad9fa64ebe835b5
https://pubmed.ncbi.nlm.nih.gov/35322150

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Use of single stranded targeting DNA or negative selection does not further increase the efficiency of a GGTA1 promoter trap

Autor: Benjamin P, Beaton, Jiude, Mao, Clifton N, Murphy, Melissa S, Samuel, Randall S, Prather, Kevin D, Wells

Publikováno v: Journal of molecular cloninggenetic recombination. 2(1)

Although several techniques have been developed to create gene knockouts in pigs, homologous recombination will continue to be required for site-specific genome modifications that are more sophisticated than gene disruption (base changes, domain exch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e54a6e3349f618389991f386f963d9cd
https://pubmed.ncbi.nlm.nih.gov/25309937

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Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos

Autor: Kristin M, Whitworth, Kiho, Lee, Joshua A, Benne, Benjamin P, Beaton, Lee D, Spate, Stephanie L, Murphy, Melissa S, Samuel, Jiude, Mao, Chad, O'Gorman, Eric M, Walters, Clifton N, Murphy, John, Driver, Alan, Mileham, David, McLaren, Kevin D, Wells, Randall S, Prather

Publikováno v: Biology of reproduction. 91(3)

Targeted modification of the pig genome can be challenging. Recent applications of the CRISPR/Cas9 system hold promise for improving the efficacy of genome editing. When a designed CRISPR/Cas9 system targeting CD163 or CD1D was introduced into somati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b49f434e43c2de6d8048bda7dd57f2d
https://pubmed.ncbi.nlm.nih.gov/25100712

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Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer

Autor: Jianguo, Zhao, Jason W, Ross, Yanhong, Hao, Lee D, Spate, Eric M, Walters, Melissa S, Samuel, August, Rieke, Clifton N, Murphy, Randall S, Prather

Publikováno v: Biology of reproduction. 81(3)

The National Institutes of Health (NIH) miniature pig was developed specifically for xenotransplantation and has been extensively used as a large-animal model in many other biomedical experiments. However, the cloning efficiency of this pig is very l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::04f55ca8864c4f13bfceabcb4360242c
https://pubmed.ncbi.nlm.nih.gov/19386991

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