Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Melissa R. Regan"'
Autor:
Jean Philippe Richard, Mariah L. Hoye, Svetlana Vidensky, Joseph D. Dougherty, Jeffrey D. Rothstein, Nicholas J. Maragakis, Timothy M. Miller, Linga V. Reddy, Leah A. Jensen, Allison M. Lake, Melissa R. Regan
Publikováno v:
Brain.
We recently demonstrated that microRNA-218 (miR-218) is greatly enriched in motor neurons and is released extracellularly in amyotrophic lateral sclerosis model rats. To determine if the released, motor neuron-derived miR-218 may have a functional ro
Autor:
Melissa R. Regan, Dwight E. Bergles, Andrew M. Watkins, Jeffrey D. Rothstein, Yu Shin Kim, Yanhua H. Huang, Lin Jin, Margaret Dykes-Hoberg
Publikováno v:
Journal of Neuroscience. 27:6607-6619
Glutamate transporters regulate excitatory neurotransmission and prevent glutamate-mediated excitotoxicity in the CNS. To better study the cellular and temporal dynamics of the expression of these transporters, we generated bacterial artificial chrom
Autor:
Andrew M. Watkins, Dwight E. Bergles, Lin Jin, Melissa R. Regan, Jeffrey D. Rothstein, Dan Gincel
Publikováno v:
Experimental Neurology. 203:205-212
The EAAT4 glutamate transporter helps regulate excitatory neurotransmission and prevents glutamate-mediated excitotoxicity in the cerebellum. Immunohistochemistry and in situ hybridization have previously defined a cerebellar cell population expressi
Autor:
Pankaj Gupta, Jeffrey D. Rothstein, Dwight E. Bergles, Yanhua H. Huang, Lin Jin, Zao-Zhong Su, Lucie I. Bruijn, Svetlana Vidensky, Christine Haenggeli, Paul B. Fisher, Dorothy S. Chung, Margaret Dykes Hoberg, Sarjubhai Patel, Shuy Vang Toan, Melissa R. Regan
Publikováno v:
Nature. 433:73-77
Glutamate is the principal excitatory neurotransmitter in the nervous system. Inactivation of synaptic glutamate is handled by the glutamate transporter GLT1 (also known as EAAT2; refs 1, 2), the physiologically dominant astroglial protein. In spite
Autor:
Linda C. Robinson, Bruce L. Tempel, Martha M. Bosma, William S. Agnew, Vasiliki P. Demas, Valerie A. Street, Doras D. Lin, Melissa R. Regan
Publikováno v:
The Journal of Neuroscience. 17:635-645
Theopisthotonos(opt) mutation arose spontaneously in a C57BL/Ks-db2Jcolony and is the only known, naturally occurring allele ofopt. This mutant mouse was first identified based on its ataxic and convulsive phenotype. Genetic and molecular data presen
Autor:
Yongjie Yang, Lydie Morel, Seng Kah Ng, Jeffrey D. Rothstein, Melissa R. Regan, Svetlana Vidensky, Christine Esau, Haruki Higashimori
Publikováno v:
The Journal of biological chemistry. 288(10)
Perisynaptic astrocytes express important glutamate transporters, especially excitatory amino acid transporter 2 (EAAT2, rodent analog GLT1) to regulate extracellular glutamate levels and modulate synaptic activation. In this study, we investigated a
Publikováno v:
Biochemical and Biophysical Research Communications. 197:100-104
A variety of glial cell types express saxitoxin (STX)-binding voltage-sensitive Na channels (1,2), although the possible role of impulse conduction in these cells is not understood. Gautron et al. (1992) recently identified a 7.5 kb species of mRNA i
Autor:
Vivianne L. Tawfik, Natalie Perez, Nancy Nutile-McMenemy, Michael L. LaCroix-Fralish, Christine Haenggeli, Joyce A. DeLeo, Melissa R. Regan, Jeffrey D. Rothstein
Publikováno v:
Neuroscience. 152(4)
We have previously shown that the atypical methylxanthine, propentofylline, reduces mechanical allodynia after peripheral nerve transection in a rodent model of neuropathy. In the present study, we sought to determine whether propentofylline-induced
Autor:
Rebecca Stein, Mark C. Emerick, Robin Kunze, Dorothy A. Hanck, Melissa R. Regan, Megan M. McNulty, William S. Agnew
Publikováno v:
Proteins. 64(2)
We describe the regulated transcriptome of CACNA1G, a human gene for T-type Ca v 3.1 calcium channels that is subject to extensive alternative RNA splicing. Fifteen sites of transcript variation include 2 alternative 5'-UTR promoter sites, 2 alternat
Publikováno v:
Proteins. 59(2)
The domain structure of proteins synthesized from a single gene can be remodeled during tissue development by activities at the RNA level of gene expression. The impact of higher order RNA processing on changing patterns of protein domain selection m