Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Melissa R Pergande"'
Autor:
Jonathan D. Horvath, Maria Casas, Candice Kutchukian, Sara Creus Sánchez, Melissa R. Pergande, Stephanie M. Cologna, Sergi Simó, Rose E. Dixon, Eamonn J. Dickson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113244- (2023)
Summary: Anomalous aggregation of α-synuclein (α-Syn) is a pathological hallmark of many degenerative synucleinopathies including Lewy body dementia (LBD) and Parkinson’s disease (PD). Despite its strong link to disease, the precise molecular mec
Externí odkaz:
https://doaj.org/article/ff98fe59a9e9430e909a2ae22edbc46d
Autor:
Amrita Salvi, Laura R. Hardy, Kimberly N. Heath, Samantha Watry, Melissa R. Pergande, Stephanie M. Cologna, Joanna E. Burdette
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 36, Iss , Pp 100866- (2023)
High grade serous ovarian cancer (HGSC) arises from the fimbriated end of the fallopian tube epithelium (FTE), and in some cases, the ovarian surface epithelium (OSE). PAX8 is a commonly used biomarker for HGSC and is expressed in ∼90% of HGSC. Alt
Externí odkaz:
https://doaj.org/article/9101562bd9cc4179af9b546f9faef902
Autor:
Melissa R. Pergande, Christina Kang, Diann George, Pearl A. Sutter, Stephen J. Crocker, Stephanie M. Cologna, Maria I. Givogri
Publikováno v:
Lipids in Health and Disease, Vol 21, Iss 1, Pp 1-19 (2022)
Abstract Background Recent findings show that extracellular vesicle constituents can exert short- and long-range biological effects on neighboring cells in the brain, opening an exciting avenue for investigation in the field of neurodegenerative dise
Externí odkaz:
https://doaj.org/article/81ba21c6879f47b39112097282b4e604
Autor:
Amrita Salvi, Alexandria N. Young, Andrew C. Huntsman, Melissa R. Pergande, Melissa A. Korkmaz, Rathnayake A. Rathnayake, Brittney K. Mize, A. Douglas Kinghorn, Xiaoli Zhang, Kiira Ratia, Markus Schirle, Jason R. Thomas, Scott M. Brittain, Claude Shelton, Leslie N. Aldrich, Stephanie M. Cologna, James R. Fuchs, Joanna E. Burdette
Publikováno v:
Cell Death and Disease, Vol 13, Iss 1, Pp 1-13 (2022)
Abstract PHY34 is a synthetic small molecule, inspired by a compound naturally occurring in tropical plants of the Phyllanthus genus. PHY34 was developed to have potent in vitro and in vivo anticancer activity against high grade serous ovarian cancer
Externí odkaz:
https://doaj.org/article/e4c4de122bed46cdace434fd84397a5c
Autor:
Tova M. Bergsten, Sarah E. Levy, Katherine E. Zink, Hannah J. Lusk, Melissa R. Pergande, Stephanie M. Cologna, Joanna E. Burdette, Laura M. Sanchez
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
High grade serous ovarian cancer (HGSOC), the most lethal histotype of ovarian cancer, frequently arises from fallopian tube epithelial cells (FTE). Once transformed, tumorigenic FTE often migrate specifically to the ovary, completing the crucial pri
Externí odkaz:
https://doaj.org/article/77c0cd2b2aba4b908dd0581ef235cc96
Autor:
Koralege C. Pathmasiri, Melissa R. Pergande, Fernando Tobias, Rima Rebiai, Avia Rosenhouse-Dantsker, Ernesto R. Bongarzone, Stephanie M. Cologna
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 7, Pp 1004-1013 (2020)
Niemann-Pick disease type C1 (NPC1) is a lipid storage disorder in which cholesterol and glycosphingolipids accumulate in late endosomal/lysosomal compartments because of mutations in the NPC1 gene. A hallmark of NPC1 is progressive neurodegeneration
Externí odkaz:
https://doaj.org/article/44c36cca532149f597b96fb3e2fdcc90
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:668-675
Autor:
Hang-Soo Park, Rishi Man Chugh, Melissa R. Pergande, Esra Cetin, Hiba Siblini, Sahar Esfandyari, Stephanie M. Cologna, Ayman Al-Hendy
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4633 (2022)
Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-aged women, and it typically involves elevated androgen levels. Recently, it has been reported that human bone marrow mesenchymal stem cells (hBM-MSC
Externí odkaz:
https://doaj.org/article/8e8d6312899d4ea89124c0201d34d1ff
Autor:
Matthew K. Tobin, Terilyn K. L. Stephen, Kyra L. Lopez, Melissa R. Pergande, Amelia M. Bartholomew, Stephanie M. Cologna, Orly Lazarov
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 7 (2020)
Background Brain repair mechanisms fail to promote recovery after stroke, and approaches to induce brain regeneration are scarce. Mesenchymal stem cells (MSC) are thought to be a promising therapeutic option. However, their efficacy is not fully eluc
Externí odkaz:
https://doaj.org/article/147d76f157644505a0ac5ac13c1fe57c
Autor:
Lei Duan, Sarah Calhoun, Ricardo E. Perez, Virgilia Macias, Fatima Mir, Melissa R. Pergande, Paolo Gattuso, Jeffrey A. Borgia, Carl G. Maki
Publikováno v:
Cancers, Vol 14, Iss 3, p 739 (2022)
TNBC is an aggressive cancer sub-type with limited treatment options and poor prognosis. New therapeutic targets are needed to improve outcomes in TNBC patients. PRCP is a lysosomal serine protease that cleaves peptide substrates when the penultimate
Externí odkaz:
https://doaj.org/article/df76e54c7206438ca2873b242791d130