Localization of the Dual Oxidase BLI-3 and Characterization of Its NADPH Oxidase Domain during Infection of Caenorhabditis elegans.

Autor: Ransome van der Hoeven, Melissa R Cruz, Violeta Chávez, Danielle A Garsin

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124091 (2015)

Dual oxidases (DUOX) are enzymes that contain an NADPH oxidase domain that produces hydrogen peroxide (H2O2) and a peroxidase domain that can utilize H2O2 to carry out a variety of reactions. The model organism Caenorhabditis elegans produces the DUO

Externí odkaz: https://doaj.org/article/89bd3435931b48d584669a9a20047d43

Structural and functional analysis of EntV reveals a 12 amino acid fragment protective against fungal infections

Autor: Melissa R. Cruz, Shane Cristy, Shantanu Guha, Giuseppe Buda De Cesare, Elena Evdokimova, Hiram Sanchez, Dominika Borek, Pedro Miramón, Junko Yano, Paul L. Fidel, Alexei Savchenko, David R. Andes, Peter J. Stogios, Michael C. Lorenz, Danielle A. Garsin

Publikováno v: Nature Communications. 13

Fungal pathogens are a continuing challenge due to few effective antifungals and a rise in resistance. In previous work, we described the inhibition of Candida albicans virulence following exposure to the 68 amino acid bacteriocin, EntV, secreted by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fedb15cdb33ab3829e77703bbb4efdd2
https://doi.org/10.1038/s41467-022-33613-1

Ribonuclease J-Mediated mRNA Turnover Modulates Cell Shape, Metabolism and Virulence in Corynebacterium diphtheriae

Autor: Manuel Wittchen, Asis Das, Chungyu Chang, Melissa R. Cruz, Ju Huck Lee, Andreas Tauch, Danielle A. Garsin, Hung Ton-That, Yi-Wei Chen, Truc Thanh Luong, HyLam Ton-That, Minh Tan Nguyen

Publikováno v: Microorganisms
Microorganisms, Vol 9, Iss 389, p 389 (2021)
Volume 9
Issue 2

Controlled RNA degradation is a crucial process in bacterial cell biology for maintaining proper transcriptome homeostasis and adaptation to changing environments. mRNA turnover in many Gram-positive bacteria involves a specialized ribonuclease calle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::854f84515a2ccb88d9a4428b1a52799b
http://europepmc.org/articles/PMC7917786

Cardiac Microlesions Form During Severe Bacteremic Enterococcus faecalis Infection

Autor: Kavindra V. Singh, Liezl E. Francisco, Karan Gautam Kaval, Melissa R. Cruz, Barbara E. Murray, Armand O. Brown, Danielle A. Garsin

Enterococci, such as Enterococcus faecalis, are a significant cause of hospital-acquired bacteremia and mortality among the elderly and patients with comorbid conditions in the healthcare setting. In this study, the novel discovery is made that cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66752576274c1c579cfc3fedfa29238
https://doi.org/10.1101/2020.01.14.906669

Antimicrobial sensing coupled with cell membrane remodeling mediates antibiotic resistance and virulence in Enterococcus faecalis

Autor: Ayesha Khan, Orville Pemberton, Diana Panesso, Truc T. Tran, Rafael Rios, Paul J. Planet, Sara D. Siegel, Cesar A. Arias, Sandra Rincon, Danielle A. Garsin, Hung Ton-That, Jinnethe Reyes, Milya Davlieva, Lorena Diaz, Melissa R. Cruz, April H. Nguyen, Yousif Shamoo, Kavindra V. Singh, William R. Miller, Apurva Narechania, Mauricio Latorre

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 52
Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque

Bacteria have developed several evolutionary strategies to protect their cell membranes (CMs) from the attack of antibiotics and antimicrobial peptides (AMPs) produced by the innate immune system, including remodeling of phospholipid content and loca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606aa1dc7abfe6461eecb381a3a01533
https://escholarship.org/uc/item/8j65h21n