Výsledky vyhledávání - "Melissa Precopio"

Data from Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8

Autor: Sudhir Agrawal, Ekambar R. Kandimalla, Jimmy X. Tang, Dong Yu, Tao Lan, Melissa Precopio, Daqing Wang

Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptors 7 and 8 (TLR7 and TLR8). We have reported a novel class of synthetic oligoribonucleotides, referred to as stabilized immune-modulatory RNA compounds, which act as agonis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3359f37bace781823b119113ff4406ce
https://doi.org/10.1158/1535-7163.c.6531882.v1

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Synthesis and immunological activities of novel agonists of toll-like receptor 9

Autor: Weiwen Jiang, Sudhir Agrawal, Andrew J. Bett, Ireneusz Nowak, Thomas Wisniewski, Sheri Dubey, Zhenhua Sun, Mallikarjuna Putta, Melissa Precopio, Danilo R. Casimiro, Hao Wang, Dong Yu, Ekambar R. Kandimalla, Jimmy X. Tang, Mary Struthers

Publikováno v: Cellular Immunology. 263:105-113

Novel agonists of TLR9 with two 5'-ends and synthetic immune stimulatory motifs, referred to as immune modulatory oligonucleotides (IMOs) are potent agonists of TLR9. In the present study, we have designed and synthesized 15 novel IMOs by incorporati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c3d4873025f0b4fb4bca36d843969c
https://doi.org/10.1016/j.cellimm.2010.03.005

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Synthesis of tungsten compounds with Schiff base ligands prepared from ferrocenecarboxaldehyde: Observation of the migration of an imine double bond

Autor: Janet L. Shaw, Melissa Precopio, Ronald M. Jarret, Kerianne Crandall, Richard S. Herrick, Christopher J. Ziegler

Publikováno v: Journal of Organometallic Chemistry. 693:619-624

The one-pot reactions of ferrocenecarboxaldehyde, W(CO)4(pip)2 (pip = piperidine) and either 2-(aminomethyl)pyridine or 2-(2-aminoethyl)pyridine lead to clean formation of pyridine imine products W(CO)4(η2-NC5H4CH NCH2C5H4FeCp) (1) and W(CO)4(η2-NC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e2252845bcb1c184af36eefa108b610f
https://doi.org/10.1016/j.jorganchem.2007.11.046

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Synthesis and immunological activities of novel Toll-like receptor 7 and 8 agonists

Autor: Mary Struthers, Weiwen Jiang, Melissa Precopio, Zhenhua Sun, Hao Wang, Tao Lan, Sheri Dubey, Ekambar R. Kandimalla, Thomas Wisniewski, Andrew J. Bett, Sudhir Agrawal, Danilo R. Casimiro

Publikováno v: Cellular immunology. 270(2)

Single-stranded oligoribonucleotides (ORNs) stimulate innate immune responses through TLR7 and TLR8. Specific linkages and chemical modifications incorporated into synthetic ORN can greatly enhance nuclease stability, selectivity, and potency. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d519d7f64c27e06ee62c0356263579a
https://pubmed.ncbi.nlm.nih.gov/21570062

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Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8

Autor: Jimmy X. Tang, Dong Yu, Sudhir Agrawal, Melissa Precopio, Tao Lan, Daqing Wang, Ekambar R. Kandimalla

Publikováno v: Molecular cancer therapeutics. 9(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a1477d367fbee217fc1849c29bbcc6a
https://pubmed.ncbi.nlm.nih.gov/20515950

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Modification of immune activation in HIV-1-infected humanized mouse model using TLR7/9 antagonists (113.19)

Autor: J. Judy Chang, Robert Lindsay, Erin Doyle, Vladimir Vrbanac, Edward Seung, Timothy Dudek, Melissa Precopio, Ekambar Kandimalla, Andrew Tager, Marcus Altfeld

Publikováno v: The Journal of Immunology. 188:113.19-113.19

Background: T cell immune activation is a strong predictor of HIV-1 disease progression, and IFNα production following TLR7 stimulation has been associated with elevated CD8+ T cell activation. We hypothesize that modulation of TLR7 stimulation coul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91f6a02f6a08b5864e4dd93ad1c23c96
https://doi.org/10.4049/jimmunol.188.supp.113.19

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IMO-4200, a Novel TLR7 and TLR8 Dual Agonist, Enhances Antitumor Effect of Ofatumumab, Rituximab and Cytotoxics in Preclinical Models of Hematological Malignancies

Autor: Jimmy X. Tang, Ekambar R. Kandimalla, Sudhir Agrawal, Daqing Wang, Melissa Precopio, Michael J. Reardon, Nicola La Monica, Tao Lan, Alice Bexon

Publikováno v: Blood. 118:3724-3724

Abstract 3724 Background Toll-like receptors (TLR) are ideal targets for combination therapy of hematological malignancies as they modulate immune responses and can influence the tumor microenvironment through cytokine and chemokine induction. TLR-ta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0286f528786af115692e57b10afee92d
https://doi.org/10.1182/blood.v118.21.3724.3724

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Supra-additive effect of IMO-4200, a novel TLR7 and TLR8 dual agonist, with rituximab and cytotoxics in preclinical models of hematologic malignancies

Autor: Daqing Wang, Tao Lan, Alice Bexon, Jimmy X. Tang, Michael J. Reardon, Sudhir Agrawal, Ekambar R. Kandimalla, Melissa Precopio, N. La Monica

Publikováno v: Journal of Clinical Oncology. 29:e13076-e13076

e13076 Background: IMO-4200, a dual agonist of toll-like receptors (TLR) 7 and 8, induces potent Th-1 immune responses and exerts significant antitumor effects in a number of tumor models. In this ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7e7260d5c4ec666ae0ff7979f8067152
https://doi.org/10.1200/jco.2011.29.15_suppl.e13076

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Antitumor Activity of An RNA-Based Agonist of TLR7 and 8 In Preclinical Models of Hematological Malignancies

Autor: Melissa Precopio, Tao Lan, Michael J. Reardon, Daqing Wang, Jimmy X. Tang, Sudhir Agrawal, Nicola La Monica, Ekambar R. Kandimalla

Publikováno v: Blood. 116:421-421

Abstract 421 Treatment of hematological malignancies, non-Hodgkins lymphoma in particular, has evolved greatly in the past decade with the advent of rituximab, proteasome inhibitors and other new agents. Nonetheless, the need remains for effective ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90a7c95c2233674fd2fbeee11e64fb35
https://doi.org/10.1182/blood.v116.21.421.421

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