Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melissa Plone"'
Autor:
Jose Cangiano, John Robertson, John Hunter, Ramon Añel, Harold Locay, Anita Patel, Sara Engstrand, Christine Darwin, Melissa Plone
Publikováno v:
Dialysis & Transplantation. 40:252-257
OBJECTIVE No well-controlled studies of the safety and efficacy of active vitamin D analogues have been conducted in vitamin D-replete (25-hydroxyvitamin D ≥ 30 ng/mL) patients. This study assessed the safety and efficacy of doxercalciferol in vita
Autor:
Calum N. Ross, Sandip Mitra, Jeremy Heaton, Melissa Plone, Stanley Fan, Philip A. Kalra, Nick Pritchard, John Hunter
Publikováno v:
Nephrology Dialysis Transplantation
Background Sevelamer carbonate is an improved, buffered form of sevelamer hydrochloride developed for the treatment of hyperphosphataemia in CKD patients. Sevelamer carbonate formulated as a powder for oral suspension presents a novel, patient-friend
Publikováno v:
Clinical Pharmacokinetics. 41:517-523
To examine the absorption, distribution and excretion of sevelamer hydrochloride in rats and humans.Twelve male Sprague-Dawley rats were used in the animal study, and twenty human volunteers participated in the clinical trial.In the animal study, six
Publikováno v:
Annals of the New York Academy of Sciences. 1054:492-494
Deferitrin, a novel, orally available iron chelator, is in the early stage of clinical development for the treatment of chronic iron overload due to transfusional therapy. Preclinical pharmacology studies demonstrate iron excretion largely by the fec
Autor:
Zhaohui Ni, Gengru Jiang, Xiaoqiang Ding, Fan Fan Hou, Bi-Cheng Liu, Xuequing Yu, Xuemei Li, Li Zuo, Yan La, Jianghua Chen, Ping Fu, John Hunter, Li Wang, Changying Xing, Nan Chen, Xiongfei Wu, John Neylan, Chaoxing Huang, Maureen Dillon, Jun-zhou Fu, Melissa Plone, Changlin Mei
Publikováno v:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 29(1)
BACKGROUND Hyperphosphataemia in patients with advanced chronic kidney disease (CKD) is associated with adverse outcomes, including vascular calcification and higher mortality rates. While phosphate lowering is an integral aspect of CKD management, t
Autor:
Martin, Hanus, Eugene, Zhorov, Deborah, Brommage, Melissa, Plone, Stephen Randall, Holmes-Farley
Publikováno v:
Nephrology nursing journal : journal of the American Nephrology Nurses' Association. 39(3)
This study investigated mixing sevelamer carbonate powder with foods and beverages other than water. Food samples, including applesauce, oatmeal, chicken, protein powder, scrambled eggs, ginger ale, and diet ginger ale, were subjected to an in vitro
Autor:
Joachim Hertel, Srinivas Hariachar, John Hunter, Melissa Plone, Sara Engstrand, Ajay Duggal, Marializa Bernardo, Alejandro R. Gonzalez, K. Shashi Kant
Publikováno v:
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 22(1)
Objective The purpose of the 2 studies presented in this article was to determine the clinically appropriate dose of doxercalciferol capsules that is required to maintain similar intact parathyroid hormone control when converting from intravenous (IV
Autor:
Srinivas Hariachar, Jeremy Heaton, Wadi N. Suki, Steven Fishbane, James A. Delmez, Sharon M. Moe, Scott Chasan-Taber, Melissa Plone
Publikováno v:
American journal of kidney diseases : the official journal of the National Kidney Foundation. 55(2)
Sevelamer carbonate powder for oral suspension is a new dosage form of sevelamer, which may be suited to once-daily dosing.Randomized parallel open-label study.Hemodialysis patients.After a 2-week phosphate-binder washout, patients were randomly assi
Autor:
Martin Hanus, Eugene Zhorov, Rafif Dagher, Melissa Plone, Jeffrey M. Goldberg, Steven K. Burke, Ajay Duggal
Publikováno v:
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 16(3)
Sevelamer, a nonabsorbed, calcium- and metal-free dietary phosphate binder, consists of a polyallylamine polymer backbone with a cationic charge that shows a high capacity for binding anionically charged compounds such as phosphate. The currently lic
Autor:
Maureen A. Dillon, Melissa Plone, Kenneth N. Cline, Danny Fischer, Steven K. Burke, Andrew T. Blair
Publikováno v:
American journal of kidney diseases : the official journal of the National Kidney Foundation. 48(3)
Background: Patients with renal failure require complex regimens of renal replacement therapies and medications, including ingestion of phosphate-binding agents 3 times daily. Previous studies suggested that sevelamer may provide extended phosphate b