Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Melissa P. Lokugamage"'
Autor:
Huanzhen Ni, Marine Z. C. Hatit, Kun Zhao, David Loughrey, Melissa P. Lokugamage, Hannah E. Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.
Externí odkaz:
https://doaj.org/article/a3a05515d75242a7919700c5dcde3bf7
Autor:
Sebastian G. Huayamares, Melissa P. Lokugamage, Alejandro J. Da Silva Sanchez, James E. Dahlman
Publikováno v:
Current Research in Biotechnology, Vol 4, Iss , Pp 392-401 (2022)
Biotechnologies are being commercialized at historic rates. In 2020, 74 biotech startups went public through an initial public offering (IPO) and 60 went through the IPO process in the first six months of 2021. However, the traits associated with bio
Externí odkaz:
https://doaj.org/article/c30e2096e5a040c5a8036c87302a70c8
Autor:
Zubao Gan, Melissa P. Lokugamage, Marine Z. C. Hatit, David Loughrey, Kalina Paunovska, Manaka Sato, Ana Cristian, James E. Dahlman
Publikováno v:
Bioengineering & Translational Medicine, Vol 5, Iss 3, Pp n/a-n/a (2020)
Abstract Once inside the cytoplasm of a cell, mRNA can be used to treat disease by upregulating the expression of any gene. Lipid nanoparticles (LNPs) can deliver mRNA to hepatocytes in humans, yet systemic non‐hepatocyte delivery at clinical doses
Externí odkaz:
https://doaj.org/article/09c92bc7ebd54af58ade7073722c4754
Autor:
Marine Z. C. Hatit, Curtis N. Dobrowolski, Melissa P. Lokugamage, David Loughrey, Huanzhen Ni, Chiara Zurla, Alejandro J. Da Silva Sanchez, Afsane Radmand, Sebastian G. Huayamares, Ryan Zenhausern, Kalina Paunovska, Hannah E. Peck, Jinwhan Kim, Manaka Sato, Jacob I. Feldman, Michael-Alexander Rivera, Ana Cristian, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Chemistry. 15:508-515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d411f66312b8f3b3c4db27594a5df3e
https://doi.org/10.1038/s41557-023-01138-9
https://doi.org/10.1038/s41557-023-01138-9
Autor:
Afsane Radmand, Melissa P. Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G. Huayamares, Marine Z. C. Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J. Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nano Letters. 23:993-1002
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ee5f3aad88116eea784f435311926c8
https://doi.org/10.1021/acs.nanolett.2c04479
https://doi.org/10.1021/acs.nanolett.2c04479
Autor:
Curtis Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri, David Loughrey, Alejandro J. Da Silva Sanchez, Huanzhen Ni, Marine Z. C. Hatit, Melissa P. Lokugamage, Yanina Kuzminich, Hannah E. Peck, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:871-879
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5beb6a4306e31071e6b7bc2c2cb6f282
https://doi.org/10.1038/s41565-022-01146-9
https://doi.org/10.1038/s41565-022-01146-9
Autor:
Cory D. Sago, Melissa P. Lokugamage, David Loughrey, Kevin E. Lindsay, Robert Hincapie, Brandon R. Krupczak, Sujay Kalathoor, Manaka Sato, Elisa Schrader Echeverri, Jordan P. Fitzgerald, Zubao Gan, Lena Gamboa, Kalina Paunovska, Carlos A. Sanhueza, Marine Z. C. Hatit, M. G. Finn, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Biomedical Engineering. 6:157-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e8d05bf56456cbf86e57da6eb41c3f7
https://doi.org/10.1038/s41551-022-00847-9
https://doi.org/10.1038/s41551-022-00847-9
Autor:
Marine Z. C. Hatit, Melissa P. Lokugamage, Curtis N. Dobrowolski, Kalina Paunovska, Huanzhen Ni, Kun Zhao, Daryll Vanover, Jared Beyersdorf, Hannah E. Peck, David Loughrey, Manaka Sato, Ana Cristian, Philip J. Santangelo, James E. Dahlman
Publikováno v:
Nature Nanotechnology. 17:310-318
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff65c7ba59890ec94d1cb948b4e910f
https://doi.org/10.1038/s41565-021-01030-y
https://doi.org/10.1038/s41565-021-01030-y
Autor:
Jared Beyersdorf, YongTae Kim, Huanzhen Ni, James E. Dahlman, Elisa Schrader Echeverri, Daryll Vanover, Marine Z. C. Hatit, Jeong-Kee Yoon, Melissa P. Lokugamage, Philip J. Santangelo, Hannah E. Peck, Laura Rotolo
Publikováno v:
Nature Biomedical Engineering. 5:1059-1068
Lipid nanoparticles (LNPs) for the efficient delivery of drugs need to be designed for the particular administration route and type of drug. Here we report the design of LNPs for the efficient delivery of therapeutic RNAs to the lung via nebulization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5b20432f2dcecc6f5da64dfd78d16f3
https://doi.org/10.1038/s41551-021-00786-x
https://doi.org/10.1038/s41551-021-00786-x
Autor:
Curtis, Dobrowolski, Kalina, Paunovska, Elisa, Schrader Echeverri, David, Loughrey, Alejandro J, Da Silva Sanchez, Huanzhen, Ni, Marine Z C, Hatit, Melissa P, Lokugamage, Yanina, Kuzminich, Hannah E, Peck, Philip J, Santangelo, James E, Dahlman
Publikováno v:
Nature nanotechnology. 17(8)
Cells that were previously described as homogeneous are composed of subsets with distinct transcriptional states. However, it remains unclear whether this cell heterogeneity influences the efficiency with which lipid nanoparticles (LNPs) deliver mess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8dcce55c089a1aa29138cdd00365fb1c
https://pubmed.ncbi.nlm.nih.gov/35768613
https://pubmed.ncbi.nlm.nih.gov/35768613