Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Melissa Nassif"'
Autor:
Pablo Ahumada Montalva, Carolina Jerez, Sara Borquez, Francisco Muñoz, Melissa Nassif, Mario Sanhueza, Rene Vidal, Diego Rojas Rivera
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S488- (2023)
Externí odkaz:
https://doaj.org/article/805ed957537a43e3bf4a406a834b52bb
Autor:
Denisse Sepúlveda, Felipe Grunenwald, Alvaro Vidal, Paulina Troncoso-Escudero, Marisol Cisternas-Olmedo, Roque Villagra, Pedro Vergara, Carlos Aguilera, Melissa Nassif, Rene L. Vidal
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Insulin-like growth factor 2 (IGF2) and autophagy-related genes have been proposed as biomolecules of interest related to idiopathic Parkinson’s disease (PD). The objective of this study was to determine the IGF2 and IGF1 levels in plasma
Externí odkaz:
https://doaj.org/article/94b8c6f1859e461084e81569e52e168b
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin
Externí odkaz:
https://doaj.org/article/ade956d219374b4fbaa3c4d8f20d7362
Autor:
Sandra Espinoza, Felipe Grunenwald, Wileidy Gomez, Felipe García, Lorena Abarzúa-Catalan, Sebastián Oyarce-Pezoa, Maria Fernanda Hernandez, Bastián I. Cortés, Markus Uhrig, Daniela P. Ponce, Claudia Durán-Aniotz, Claudio Hetz, Carol D. SanMartín, Victor H. Cornejo, Fernando Ezquer, Valentina Parra, Maria Isabel Behrens, Patricio A. Manque, Diego Rojas-Rivera, René L. Vidal, Ute Woehlbier, Melissa Nassif
Publikováno v:
Cells, Vol 11, Iss 12, p 1860 (2022)
Alzheimer’s disease (AD) is the most prevalent age-associated neurodegenerative disease. A decrease in autophagy during aging contributes to brain disorders by accumulating potentially toxic substrates in neurons. Rubicon is a well-established inhi
Externí odkaz:
https://doaj.org/article/2c0619b110c14ca2bc7f93cba197acc2
Autor:
Emiliano Vicencio, Sebastián Beltrán, Luis Labrador, Patricio Manque, Melissa Nassif, Ute Woehlbier
Publikováno v:
Cells, Vol 9, Iss 2, p 381 (2020)
Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disorder that progressively affects motor neurons in the brain and spinal cord. Due to the biological complexity of the disease, its etiology remains unknown. Several cellular mechanis
Externí odkaz:
https://doaj.org/article/5a0b4c2bfdf543d893a2b59158e6f775
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Neuroinflammation is one of the most important processes involved in the pathogenesis of Parkinson's disease (PD). The current concept of neuroinflammation comprises an inflammation process, which occurs in the central nervous system due to molecules
Externí odkaz:
https://doaj.org/article/1f6a71ed4425476e85b9c757d0064a43
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and genomics have revealed intr
Externí odkaz:
https://doaj.org/article/eafa8f3140af4e619ea0fd8a746463fa
Autor:
Lauren L. Zamin, Patrícia Dillenburg-Pilla, Ricardo Argenta-Comiran, Ana Paula Horn, Fabrício Simão, Melissa Nassif, Daniéli Gerhardt, Rudimar L. Frozza, Christianne Salbego
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 1, Pp 170-182 (2006)
Here we investigated the neuroprotective effect of resveratrol in an in vitro model of ischemia. We used organotypic hippocampal cultures exposed to oxygen–glucose deprivation (OGD). In OGD-vehicle exposed cultures, about 46% of the hippocampus was
Externí odkaz:
https://doaj.org/article/3af4cf938f27490ca189eac791117f98
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e66672 (2013)
Endoplasmic reticulum (ER) stress represents an early pathological event in amyotrophic lateral sclerosis (ALS). ATF4 is a key ER stress transcription factor that plays a role in both adaptation to stress and the activation of apoptosis. Here we inve
Externí odkaz:
https://doaj.org/article/53bfd4ef4d274e919c15fe58673aceef
Autor:
Patricio Manque, Nohela B Arévalo, Maria I. Behrens, Ute Woehlbier, Carol D. SanMartín, Esteban Leyton, Paola Murgas, Claudia Duran-Aniotz, Bastián I Cortés, Sandra Espinoza, Wileidy Gomez, Diego Matus, José Matías Benitez, Melissa Nassif, Claudio Hetz
Publikováno v:
Journal of Alzheimer's Disease. 82:S163-S178
Background: Disturbances in the autophagy/endolysosomal systems are proposed as early signatures of Alzheimer’s disease (AD). However, few studies are available concerning autophagy gene expression in AD patients. Objective: To explore the differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b5e1b155b19cfd6abb30af23427f8f
https://doi.org/10.3233/jad-201264
https://doi.org/10.3233/jad-201264