Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melissa N. Hart"'
Autor:
Melissa N. Hart, Franziska Mohring, Sophia M. DonVito, James A. Thomas, Nicole Muller-Sienerth, Gavin J. Wright, Ellen Knuepfer, Helen R. Saibil, Robert W. Moon
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs
Externí odkaz:
https://doaj.org/article/c48e41643e4c4f30a28ba70dc114bca3
Autor:
Ryan C. Henrici, Rachel L. Edwards, Martin Zoltner, Donelly A. van Schalkwyk, Melissa N. Hart, Franziska Mohring, Robert W. Moon, Stephanie D. Nofal, Avnish Patel, Christian Flueck, David A. Baker, Audrey R. Odom John, Mark C. Field, Colin J. Sutherland
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin enco
Externí odkaz:
https://doaj.org/article/783ffd262b134205b1f7de614ed72d61
Autor:
Brendan Farrell, Nawsad Alam, Melissa N. Hart, Abhishek Jamwal, Robert J. Ragotte, Hannah Walters-Morgan, Simon J. Draper, Ellen Knuepfer, Matthew K. Higgins
The symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The five-component PfPCRCR complex, containing PfRH5, PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f04cd68928d397a3b4e8c1a6cfdc1e2b
https://doi.org/10.1101/2023.01.30.526221
https://doi.org/10.1101/2023.01.30.526221
Autor:
Melissa N. Hart, Franziska Mohring, Sophia M. Donvito, James A. Thomas, Nicole Muller-Sienerth, Gavin J. Wright, Ellen Knuepfer, Helen R. Saibil, Robert W. Moon
SummaryInvasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb823e217e4a7a3d7bf4ac4c042644f6
https://doi.org/10.1101/2022.08.09.503398
https://doi.org/10.1101/2022.08.09.503398
Autor:
Kazuhide, Yahata, Melissa N, Hart, Heledd, Davies, Masahito, Asada, Samuel C, Wassmer, Thomas J, Templeton, Moritz, Treeck, Robert W, Moon, Osamu, Kaneko
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Plasmodium malaria parasites use a unique substrate-dependent locomotion, termed gliding motility, to migrate through tissues and invade cells. Previously, it was thought that the small labile invasive stages that invade erythrocytes, me
Autor:
Kazuhide Yahata, Heledd Davies, Melissa N. Hart, Robert W. Moon, Masahito Asada, Moritz Treeck, Thomas J. Templeton, Osamu Kaneko
Plasmodium malaria parasites are obligate intracellular protozoans that use a unique form of locomotion, termed gliding motility, to move through host tissues and invade cells. The process is substrate-dependent and powered by an actomyosin motor tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b440ba6e42ef2cdd8e0fc4a29832ecd4
Autor:
Martin Zoltner, Franziska Mohring, David A. Baker, Avnish Patel, Christian Flueck, Rachel L. Edwards, Mark C. Field, Robert W. Moon, Donelly A. van Schalkwyk, Stephanie D. Nofal, Colin J. Sutherland, Ryan C. Henrici, Melissa N. Hart, Audrey R. Odom John
Publikováno v:
mBio, Vol 11, Iss 1, p e02918-19 (2020)
mBio
mBio, Vol 11, Iss 1 (2020)
mBio
mBio, Vol 11, Iss 1 (2020)
We examine in detail the AP-2 adaptin complex from the malaria parasite Plasmodium falciparum. In most studied organisms, AP-2 is involved in bringing material into the cell from outside, a process called endocytosis. Previous work shows that changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b1077644e7070b5f115b3d04b22968
Autor:
Heledd Davies, Kazuhide Yahata, Melissa N. Hart, Robert W. Moon, Osamu Kaneko, Moritz Treeck, Thomas J. Templeton, Masahito Asada, Samuel C. Wassmer
Publikováno v:
Proceedings of the National Academy of Sciences. 118(48):e2114442118
Plasmodium malaria parasites are obligate intracellular protozoans that use a unique form of locomotion, termed gliding motility, to move through host tissues and invade cells. The process is substrate dependent and powered by an actomyosin motor tha
Publikováno v:
Bio Protoc
Plasmodium knowlesi is a zoonotic malaria parasite in Southeast Asia that can cause severe and fatal malaria in humans. The main hosts are Macaques, but modern diagnostic tools reveal increasing numbers of human infections. After P. falciparum, P. kn
Autor:
Simon J. Draper, Melissa N. Hart, James Charleston, Susana Campino, Joanna Hall, Ernest Diez Benavente, Taane G. Clark, Colin J. Sutherland, David A. Baker, Avnish Patel, Franziska Mohring, Thomas A. Rawlinson, Neil Almond, Ryan C. Henrici, Robert W. Moon
Publikováno v:
eLife, Vol 8 (2019)
Tackling relapsing Plasmodium vivax and zoonotic Plasmodium knowlesi infections is critical to reducing malaria incidence and mortality worldwide. Understanding the biology of these important and related parasites was previously constrained by the la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d170839b1dbd535707c2bff0c45e6bf
https://researchonline.lshtm.ac.uk/id/eprint/4653398/1/elife-45829-v1.pdf
https://researchonline.lshtm.ac.uk/id/eprint/4653398/1/elife-45829-v1.pdf