Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis.

Autor: Melissa N van Tok, Nataliya G Yeremenko, Christine A Teitsma, Barbara E Kream, Véronique L Knaup, Rik J Lories, Dominique L Baeten, Leonie M van Duivenvoorde

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0163632 (2016)

Insulin like growth factor (IGF)-I can act on a variety of cells involved in cartilage and bone repair, yet IGF-I has not been studied extensively in the context of inflammatory arthritis. The objective of this study was to investigate whether IGF-I

Externí odkaz: https://doaj.org/article/030aabf482754014b446c5a5712e7c94

Dual Blockade of TNF and IL-17A Inhibits Inflammation and Structural Damage in a Rat Model of Spondyloarthritis

Autor: Ihsan Hammoura, Renee H. Fiechter, Shaughn H. Bryant, Susan Westmoreland, Gillian Kingsbury, Wendy Waegell, Sander W. Tas, Dominique L. Baeten, Marleen G. H. van de Sande, Melissa N. van Tok, Leonie M. van Duivenvoorde

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 2; Pages: 859
Hammoura, I, Fiechter, R H, Bryant, S H, Westmoreland, S, Kingsbury, G, Waegell, W, Tas, S W, Baeten, D L, van de Sande, M G H, van Tok, M N & van Duivenvoorde, L M 2022, ' Dual Blockade of TNF and IL-17A Inhibits Inflammation and Structural Damage in a Rat Model of Spondyloarthritis ', International Journal of Molecular Sciences, vol. 23, no. 2, 859 . https://doi.org/10.3390/ijms23020859
International Journal of Molecular Sciences, 23(2):859. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, Vol 23, Iss 859, p 859 (2022)
International Journal of Molecular Sciences
International journal of molecular sciences, 23(2):859. Multidisciplinary Digital Publishing Institute (MDPI)

The tumor necrosis factor (TNF) and IL-23/IL-17 axes are the main therapeutic targets in spondyloarthritis. Despite the clinical efficacy of blocking either pathway, monotherapy does not induce remission in all patients and its effect on new bone for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5f1f63d1651f69dc2e508db8c0637d

The Transcriptional Coactivator Bob1 Is Associated With Pathologic B Cell Responses in Autoimmune Tissue Inflammation

Autor: Melissa N van Tok, Dominique Baeten, Frans G. M. Kroese, Hergen Spits, Nataliya Yeremenko, Tineke Cantaert, Juan D. Cañete, Maria J. Levels, Kristine Germar

Publikováno v: Arthritis & Rheumatology, 69(4), 750-762. Wiley
Arthritis & rheumatology (Hoboken, N.J.), 69(4), 750-762. John Wiley and Sons Ltd
Arthritis & Rheumatology

Objective. The molecular mechanisms steering abnormal B cell responses in autoimmune diseases remain poorly understood. We undertook this study to identify molecular switches controlling pathologic B cell responses in rheumatoid arthritis (RA).Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52b531d71a5ace92ecbc3da047aff775
https://hdl.handle.net/11370/bb5a18d2-b68e-4412-b049-83f016b6a3f9

The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling

Autor: Melissa N. van Tok, Songqing Na, Christopher R. Lao, Marina Alvi, Desirée Pots, Marleen G. H. van de Sande, Joel D. Taurog, Jonathon D. Sedgwick, Dominique L. Baeten, Leonie M. van Duivenvoorde

Publikováno v: Frontiers in Immunology, Vol 9 (2018)
Frontiers in immunology, 9(JUL):1550. Frontiers Media S.A.
Frontiers in Immunology

IL-17A is a central driver of spondyloarthritis (SpA), its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence suggests, however, that IL-17A and IL-23 have a partially overlapping but distinct biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6133c325556325c8e73b23a58876370
https://www.frontiersin.org/article/10.3389/fimmu.2018.01550/full

Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats

Autor: Melissa N. van Tok, Nimman Satumtira, Martha Dorris, Desirée Pots, Gleb Slobodin, Marleen G. van de Sande, Joel D. Taurog, Dominique L. Baeten, Leonie M. van Duivenvoorde

Publikováno v: Frontiers in Immunology
Frontiers in immunology, 8. Frontiers Media S.A.
Frontiers in Immunology, Vol 8 (2017)

Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8(+) T cells are not required for disease induction in the HLA-B27/Huβ2m transgenic rats. We used Lewis HLA-B27/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eceaa3593e5fa909ebc5eadf26600b8