Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Melissa Mun"'
Autor:
Patrick Ahyow, Angela Meier, Melissa Mun, Christopher M. Rose, Inn H. Yuk, Wendy Sandoval, Anh Nguyen Dang
Publikováno v:
Biotechnology and Bioengineering.
The extent of afucosylation, which refers to the absence of core fucose on Fc glycans, can correlate positively with the antibody-dependent cellular cytotoxicity (ADCC) activity of a monoclonal antibody (mAb). Therefore, it is important to maintain c
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Autor:
Michael W. Laird, Melissa Mun, Melody Trexler-Schmidt, James Dvornicky, Yung-Hsiang Kao, Stefanie Khoo, Aline Do Minh
Publikováno v:
Biotechnology and Bioengineering. 112:734-742
During the scale-up of several Chinese Hamster Ovary (CHO) cell monoclonal antibody production processes, significant reduction of the antibody interchain disulfide bonds was observed. The reduction was correlated with excessive mechanical cell shear
Autor:
Jun Egawa, Reza K. Arta, Vance P. Lemmon, Melissa Muños-Barrero, Yan Shi, Michihiro Igarashi, Toshiyuki Someya
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-5 (2022)
Abstract Protein kinases are responsible for protein phosphorylation and are involved in important signal transduction pathways; however, a considerable number of poorly characterized kinases may be involved in neuronal development. Here, we consider
Externí odkaz:
https://doaj.org/article/7a5657b35acb4c48aad0a7a846d298cd
Autor:
Andrea D. Guastello, Corey Lieneman, Brittany Bailey, Melissa Munson, Megan Barthle-Herrera, Miranda Higham, Lindsay Druskin, Cheryl B. McNeil
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
This fictionalized case report captures the common themes and considerations during the diagnostic assessment and behavioral treatment of adolescents demonstrating symptoms of autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD), and a
Externí odkaz:
https://doaj.org/article/1471b4b9ca464bd79e234bf2b4362151
Autor:
Robert Darren Brooks, Melissa Mun
Publikováno v:
Emerging Markets Review. 13:1-7
The global financial crisis has again brought the interdependencies of international financial markets to the fore, particularly during times of financial crises. This paper explores the relative roles of news and volatility in explaining the changes
Air sparging for prevention of antibody disulfide bond reduction in harvested CHO cell culture fluid
Autor:
Melissa, Mun, Stefanie, Khoo, Aline, Do Minh, James, Dvornicky, Melody, Trexler-Schmidt, Yung-Hsiang, Kao, Michael W, Laird
Publikováno v:
Biotechnology and bioengineering. 112(4)
During the scale-up of several Chinese Hamster Ovary (CHO) cell monoclonal antibody production processes, significant reduction of the antibody interchain disulfide bonds was observed. The reduction was correlated with excessive mechanical cell shear
Autor:
Boyan Zhang, Natarajan Vijayasankaran, Robert Kiss, Steve Meier, Yi Yang, Amy Lim, Martin Gawlitzek, Feng Li, Sharat Varma, Melissa Mun, Silvana R. Arevalo, Trevor E. Swartz
Publikováno v:
Biotechnology progress. 29(5)
As the industry moves toward subcutaneous delivery as a preferred route of drug administration, high drug substance concentrations are becoming the norm for monoclonal antibodies. At such high concentrations, the drug substance may display a more int
Publikováno v:
Horticulturae, Vol 9, Iss 6, p 646 (2023)
Cut roses are highly valuable ornamentals and their profitability depends on the flower postharvest performance. Bent neck symptoms in roses make them unmarketable and are typically related to physiological disorders, bacteria accumulation in the vas
Externí odkaz:
https://doaj.org/article/8a0a56be690647549117bccdd96ee565
Publikováno v:
Molecular biotechnology. 45(3)
The goal of quality by design (QbD) in cell culture manufacturing is to develop manufacturing processes which deliver products with consistent critical quality attributes (CQAs). QbD approaches can lead to better process understanding through the use
Identification and prevention of antibody disulfide bond reduction during cell culture manufacturing
Autor:
Melissa Mun, Sandy Sargis, Stefanie Sze-Khoo, Michael W. Laird, Jason Chiu, Yung-Hsiang Kao, Melody Trexler-Schmidt
Publikováno v:
Biotechnology and bioengineering. 106(3)
In the biopharmaceutical industry, therapeutic monoclonal antibodies are primarily produced in mammalian cell culture systems. During the scale-up of a monoclonal antibody production process, we observed excessive mechanical cell shear as well as sig