Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Melissa Millard"'
Autor:
Teresa M DesRochers, Danielle Nadeau, Katy A Lassahn, Ashley K Elrod, Natalie W Dance, Kimberly J Burgess, Aaron L Carlson, Melissa Millard, Michael J Wick, Kathryn M Appleton
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/766d95c0b234474891756f460d0c7398
Publikováno v:
Theranostics, Vol 1, Iss 1, Pp 154-188 (2011)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. As such, integrins are central to the etiology and pathology of many di
Externí odkaz:
https://doaj.org/article/d088c92cbd2245ceb31135277e75b471
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54346 (2013)
BACKGROUND: Pancreatic cancer is one of the deadliest cancers with a 5-year survival rate of 6%. Therapeutic options are very limited and there is an unmet medical need for safe and efficacious treatments. Cancer cell metabolism and mitochondria prov
Externí odkaz:
https://doaj.org/article/6575a5b369f948ae9055202476beb125
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e1000938 (2010)
BACKGROUND: Recently, there has been a surge of interest in developing compounds selectively targeting mitochondria for the treatment of neoplasms. The critical role of mitochondria in cellular metabolism and respiration supports this therapeutic rat
Externí odkaz:
https://doaj.org/article/2f30ea8bec0b4696bb1fc9a2bb82d4bb
Autor:
Katy A. Lassahn, Ashley K. Elrod, Aaron L. Carlson, Natalie A. Dance, Melissa Millard, Michael J. Wick, Teresa M. DesRochers, Kathryn M. Appleton
Publikováno v:
Cancer Research. 83:2275-2275
Biological therapies for the treatment of cancer are utilized for the same ultimate purpose as chemically derived cancer drugs, to induce tumor cell death. However, the differing mechanisms of action often make the evaluation of biologic drug efficac
Autor:
G. Larry Maxwell, Alpa M. Nick, Michael P. Stany, Christine Wilhelm, Stephen Shuford, Lauren O’Donnell, Howland E. Crosswell, Ashley M. Smith, Thomas P. Conrads, Melissa Millard, Xiaonan Hou, Larry Puls, Alina Lotstein, Valentina Zanfagnin, David E. Orr, S. John Weroha, Lillia Holmes, Jeffrey Elder, Teresa M. DesRochers, Ashley Elrod, Qi Jin Guo, Christina Mattingly, Melissa Rayner, Matthew R. Gevaert, Anil K. Sood
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports
Scientific Reports
Although 70–80% of newly diagnosed ovarian cancer patients respond to first-line therapy, almost all relapse and five-year survival remains below 50%. One strategy to increase five-year survival is prolonging time to relapse by improving first-line
Publikováno v:
Cancer Research. 82:177-177
Adenoid cystic carcinoma (ACC) is a rare, glandular cancer whose incidence rate and limited 2D cell culture capability make it difficult to study primary patient samples. Although well characterized ACC patient-derived xenografts (PDX) have proven to
Publikováno v:
Cancer Research. 82:3086-3086
Unlike cell lines, organoids maintain most of the biological properties of the parental tissue from which the starting cells were isolated including the histology and gene expression. When organoids include clinical annotation, they become a useful,
Autor:
Melissa Millard, Kathryn M. Appleton, Ashley Elrod, Thomas P. Conrads, Kelly A. Conrads, Brian L. Hood, Teresa M. DesRochers, Lillia Holmes, Tamara Abulez, Nicholas W. Bateman
Publikováno v:
Cancer Research. 80:6018-6018
Models that accurately reflect patient drug response are essential for the clinical design of personalized treatment plans and necessary for preclinical drug development. The advancement of predictive models for rare tumor types is impeded in part, b
Publikováno v:
Journal of Medicinal Chemistry. 56:9170-9179
Nitrogen mustards, widely used as chemotherapeutics, have limited safety and efficacy. Mitochondria lack a functional nucleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents. Importantly, cancer cells have hi