Integrated multi‐omics approach reveals the role of striated muscle preferentially expressed protein kinase in skeletal muscle including its relationship with myospryn complex

Autor: Qifei Li, Jasmine Lin, Shiyu Luo, Klaus Schmitz‐Abe, Rohan Agrawal, Melissa Meng, Behzad Moghadaszadeh, Alan H. Beggs, Xiaoli Liu, Mark A. Perrella, Pankaj B. Agrawal

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 3, Pp 1003-1015 (2024)

Abstract Background Autosomal‐recessive mutations in SPEG (striated muscle preferentially expressed protein kinase) have been linked to centronuclear myopathy with or without dilated cardiomyopathy (CNM5). Loss of SPEG is associated with defective

Externí odkaz: https://doaj.org/article/4a401a4397804f1bafdbce30c8191ed7

Enhanced Stability of DNA Oligonucleotides with Partially Zwitterionic Backbone Structures in Biological Media

Autor: Melissa Meng, Boris Schmidtgall, Christian Ducho

Publikováno v: Molecules, Vol 23, Iss 11, p 2941 (2018)

Deficient stability towards nuclease-mediated degradation is one of the most relevant tasks in the development of oligonucleotide-derived biomedical agents. This hurdle can be overcome through modifications to the native oligonucleotide backbone stru

Externí odkaz: https://doaj.org/article/78ecaa1c6e084dd4b5d68101b8b53dfc

Oligonucleotide analogues with cationic backbone linkages

Autor: Christian Ducho, Melissa Meng

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 1293-1308 (2018)
Beilstein Journal of Organic Chemistry

Their unique ability to selectively bind specific nucleic acid sequences makes oligonucleotides promising bioactive agents. However, modifications of the nucleic acid structure are an essential prerequisite for their application in vivo or even in ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e840ad96f9b4661231bba312380e48
https://doaj.org/article/0e3b0ab0d1a24a0fbf21fd96e4aba461

Effect of an educational intervention on colonoscopy quality outcomes

Autor: David Pace, Matthew Miné-Goldring, Jane Brodie, John D. Harnett, Jerry McGrath, Mark Borgaonkar, Melissa Meng Ge, Bradley Evans, Darryl Boone

Publikováno v: Surgical endoscopy. 34(11)

We aimed to assess the effect of a colonoscopy skills improvement (CSI) course on quality indicators at our institution. This retrospective cohort study included ten surgeons and nine gastroenterologists practicing in a tertiary referral center who h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9f06132b9c25bccc726a55554e7aa1c
https://pubmed.ncbi.nlm.nih.gov/31820159

Oligonucleotides with Cationic Backbone and Their Hybridization with DNA:Interplay of Base Pairing and Electrostatic Attraction

Autor: Tom N. Grossmann, Boris Schmidtgall, Melissa Meng, Christian Ducho, Arne Kuepper

Publikováno v: Schmidtgall, B, Kuepper, A, Meng, M, Grossmann, T N & Ducho, C 2018, ' Oligonucleotides with Cationic Backbone and Their Hybridization with DNA : Interplay of Base Pairing and Electrostatic Attraction ', Chemistry: A European Journal, vol. 24, no. 7, pp. 1544-1553 . https://doi.org/10.1002/chem.201704338
Chemistry (Weinheim an Der Bergstrasse, Germany)
Chemistry: A European Journal, 24(7), 1544-1553. Wiley-VCH Verlag

Non‐natural oligonucleotides represent important (bio)chemical tools and potential therapeutic agents. Backbone modifications altering hybridization properties and biostability can provide useful analogues. Here, we employ an artificial nucleosyl a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f64f53aebbb6c7fe8a3a878270e9ab0
https://research.vu.nl/en/publications/e4d024b9-5dae-4f34-9d4e-5c39b7f0c72b