Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Melissa McAlonis-Downes"'
Autor:
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS)
Externí odkaz:
https://doaj.org/article/95638d30dda343ee9bedd62a7544c554
Autor:
Inmaculada Sanjuan-Ruiz, Noé Govea-Perez, Melissa McAlonis-Downes, Stéphane Dieterle, Salim Megat, Sylvie Dirrig-Grosch, Gina Picchiarelli, Diana Piol, Qiang Zhu, Brian Myers, Chao-Zong Lee, Don W Cleveland, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Luc Dupuis
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-14 (2021)
Abstract Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the t
Externí odkaz:
https://doaj.org/article/99efacbef7004ce6bd0c304590be3071
Autor:
Shuo-Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Lim, Hristelina Ilieva, Philippe A Parone, Sheue-Houy Tyan, Tsemay M Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Bui, Anne Vetto, Shuying Sun, Melissa McAlonis-Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, Gene W Yeo, Lino Tessarollo, Martin Marsala, Christopher E Shaw, Greg Tucker-Kellogg, Albert R La Spada, Clotilde Lagier-Tourenne, Sandrine Da Cruz, Don W Cleveland
Publikováno v:
eLife, Vol 8 (2019)
Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either o
Externí odkaz:
https://doaj.org/article/04213ee8809d4946acefc96cd36ba9b2
Autor:
Christine Vande Velde, Karli K McDonald, Yasmin Boukhedimi, Melissa McAlonis-Downes, Christian S Lobsiger, Samar Bel Hadj, Andre Zandona, Jean-Pierre Julien, Sameer B Shah, Don W Cleveland
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22031 (2011)
Mutations in superoxide dismutase (SOD1) are causative for inherited amyotrophic lateral sclerosis. A proportion of SOD1 mutant protein is misfolded onto the cytoplasmic face of mitochondria in one or more spinal cord cell types. By construction of m
Externí odkaz:
https://doaj.org/article/14f4e00cf1e547a98d384acdc5447147
Autor:
Jone Lopez-Erauskin, Mariana Bravo-Hernandez, Maximiliano Presa, Michael W. Baughn, Ze’ev Melamed, Melinda S. Beccari, Ana Rita Agra de Almeida Quadros, Aamir Zuberi, Karen Ling, Oleksandr Platoshyn, Elkin Niño-Jara, I. Sandra Ndayambaje, Olatz Arnold-Garcia, Melissa McAlonis-Downes, Larissa Cabrera, Jonathan W. Artates, Jennifer Ryan, Frank Bennett, Paymaan Jafar-nejad, Frank Rigo, Martin Marsala, Cathleen M. Lutz, Don W. Cleveland, Clotilde Lagier-Tourenne
The human mRNA most affected by TDP-43 loss-of-function is transcribed from theSTMN2gene and encodes stathmin-2 (also known as SCG10), whose loss is a neurodegenerative disease hallmark. Here using multiplein vivoapproaches, including transient antis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fca87f97b78a3be286544a9b3838f6
https://doi.org/10.1101/2022.12.11.519794
https://doi.org/10.1101/2022.12.11.519794
Autor:
Melanie, Jambeau, Kevin D, Meyer, Marian, Hruska-Plochan, Ricardos, Tabet, Chao-Zong, Lee, Ananya, Ray-Soni, Corey, Aguilar, Kitty, Savage, Nibha, Mishra, Nicole, Cavegn, Petra, Borter, Chun-Chia, Lin, Karen R, Jansen-West, Jie, Jiang, Fernande, Freyermuth, Nan, Li, Pierre, De Rossi, Manuela, Pérez-Berlanga, Xin, Jiang, Lilian M, Daughrity, João, Pereira, Sarav, Narayanan, Yuanzheng, Gu, Shekhar, Dhokai, Isin, Dalkilic-Liddle, Zuzanna, Maniecka, Julien, Weber, Michael, Workman, Melissa, McAlonis-Downes, Eugene, Berezovski, Yong-Jie, Zhang, James, Berry, Brian J, Wainger, Mark W, Kankel, Mia, Rushe, Christoph, Hock, Roger M, Nitsch, Don W, Cleveland, Leonard, Petrucelli, Tania F, Gendron, Fabio, Montrasio, Jan, Grimm, Magdalini, Polymenidou, Clotilde, Lagier-Tourenne
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
Hexanucleotide G
Autor:
Don W. Cleveland, Amy Taylor, Albert R. La Spada, Clotilde Lagier-Tourenne, Jie Jiang, Tania F. Gendron, Sandra Diaz Garcia, Huaxi Xu, John Ravits, Somasish Ghosh Dastidar, Lu-Lin Jiang, Leonard Petrucelli, Melissa McAlonis-Downes, María José Cubillas Rodríguez, Patrick King, Sandrine Da Cruz, Qiang Zhu, Yong Jie Zhang
Publikováno v:
Nature Neuroscience. 23:615-624
Hexanucleotide expansions in C9orf72, which encodes a predicted guanine exchange factor, are the most frequent genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although repeat expansion has been established to g
Autor:
Melissa McAlonis-Downes, Sandrine Da Cruz, Salim Megat, Qiang Zhu, Noé Govea-Perez, Diana Piol, Gina Picchiarelli, Stéphane Dieterlé, Brian Myers, Luc Dupuis, Don W. Cleveland, Clotilde Lagier-Tourenne, Sylvie Dirrig-Grosch, Inmaculada Sanjuan-Ruiz, Chao-Zong Lee
Mutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS is likely to be a major culprit in the toxicity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f96d97967de60107ba40dded3d5727e5
https://doi.org/10.1101/2020.12.16.423060
https://doi.org/10.1101/2020.12.16.423060
Autor:
Don W. Cleveland, Sarthak M Singhal, Sandrine Da Cruz, Alysson R. Muotri, Melissa McAlonis-Downes, Roy Maimon, Frank Rigo, C. Frank Bennett, Karen Ling, Thomas S. Hnasko, Cedric E Snethlage, Carlos Chillon-Marinas
Publikováno v:
Nat Neurosci
Methods to enhance adult neurogenesis by reprogramming glial cells into neurons enable production of new neurons in the adult nervous system. Development of therapeutically viable approaches to induce new neurons is now required to bring this concept
Autor:
Noe Govea-Perez, Zoltán Tomori, Atsushi Miyanohara, PeiXi Chen, Mariana Bravo-Hernández, Wenlian Zhu, Joseph D. Ciacci, Brian K. Kaspar, Dara Ditsworth, Melissa McAlonis-Downes, Thomas D. Glenn, Oleksandr Platoshyn, Vladimír Proks, Samuel L. Pfaff, Stefan Juhas, Don W. Cleveland, Sandrine Da Cruz, Michael R. Navarro, Jana Juhasova, Eric T. Ahrens, Helena Kupcova Skalnikova, Ivo Vanicky, Hana Studenovská, Takahiro Tadokoro, Martin Marsala, Yoshiomi Kobayashi, Shawn P. Driscoll, Silvia Marsala, Shang Gao
Publikováno v:
Nat Med
Nature medicine, vol 26, iss 1
Nature medicine, vol 26, iss 1
Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherited neurodegenerative disorders. In the present study we develop a subpial technique, which we show in adult animals successfully delivers adeno-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d6e6d341c49955c92f1d93ffac3ebe
https://europepmc.org/articles/PMC8171115/
https://europepmc.org/articles/PMC8171115/