Výsledky vyhledávání - "Melissa Mattia"

The p53 C Terminus Controls Site-Specific DNA Binding and Promotes Structural Changes within the Central DNA Binding Domain

Autor: James J. Manfredi, Ella Freulich, Andrew Zupnick, Tamar Kahan, Inbal Shamir, Itamar Simon, Oleg Laptenko, Melissa Mattia, William A. Freed-Pastor, Idit Shiff, Noam Kadouri, Carol Prives

Publikováno v: Molecular Cell. 57:1034-1046

DNA binding by numerous transcription factors including the p53 tumor suppressor protein constitutes a vital early step in transcriptional activation. While the role of the central core DNA binding domain (DBD) of p53 in site-specific DNA binding has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b664a7394e76e8458b05ba4436c310
https://doi.org/10.1016/j.molcel.2015.02.015

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Lysines in the tetramerization domain of p53 selectively modulate G1 arrest

Autor: Rachel Beckerman, Susan Keezer, Andrew Zupnick, Kathryn E. Yoh, Oleg Laptenko, Jinwoo Ahn, Melissa Mattia-Sansobrino, Orit Karni-Schmidt, Carol Prives, In-Ja L. Byeon

Functional in a tetrameric state, the protein product of the p53 tumor suppressor gene confers its tumor-suppressive activity by transactivating genes which promote cell-cycle arrest, senescence, or programmed cell death. How p53 distinguishes betwee

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee0c331c84cac63290674eedfde3cee4

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The C terminus of p53 binds the N-terminal domain of MDM2

Autor: Maria Lokshin, Oleg Laptenko, Assaf Friedler, Masha V. Poyurovsky, Rachel Beckerman, Chen Katz, Melissa Mattia, Lewis M. Brown, Carol Prives, Ronen Gabizon, In-Ja L. Byeon, Andrew Zupnick, Jinwoo Ahn

Publikováno v: Nature structural & molecular biology

The p53 tumor suppressor interacts with its negative regulator Mdm2 via the former’s N-terminal region and core domain. Yet the extreme p53 C-terminal region contains lysine residues ubiquitinated by Mdm2 and can bear post-translational modificatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a694a9fcea1f619f0c1760991c158f5b
https://doi.org/10.1038/nsmb.1872

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DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms

Autor: Lois Resnick-Silverman, Wen Jun Liu, Melissa Mattia, James J. Manfredi, Andrea DaCosta, Jayasri Dastidar, Abhilash Padi, Shohreh Varmeh-Ziaie, Selvon St. Clair, Luciana E. Giono

Publikováno v: Molecular Cell. 16:725-736

The Cdc25C phosphatase mediates cellular entry into mitosis. The cdc25C gene is a target for transcriptional downregulation by the tumor suppressor protein p53, and this repression can be shown to contribute to p53-dependent cell cycle arrest. Two in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aacc41dad03b5bc8a60ff4362edb307f
https://doi.org/10.1016/j.molcel.2004.11.002

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Specific expression of soluble adenylyl cyclase in male germ cells

Autor: Xiangyuan Wang, Melissa Mattia, Jochen Buck, Marco Conti, Lonny R. Levin, Meeghan L. Sinclair, Debra J. Wolgemuth

Publikováno v: Molecular Reproduction and Development. 56:6-11

The cAMP signaling pathway is an important mediator of extracellular signals in organisms from prokaryotes to higher eukaryotes. In mammals two types of adenylyl cyclase synthesize cAMP; a ubiquitous family of transmembrane isoforms regulated by G pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::091e2c79c06e132ae593cd98dcb3cc1d
https://doi.org/10.1002/(sici)1098-2795(200005)56:1<6::aid-mrd2>3.0.co

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A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint

Autor: Melissa J. Peart, James L. Manley, Carol Prives, Rachel Beckerman, Melissa Mattia, Joaquín M. Espinosa, Aaron J Donner

We reported previously that when cells are arrested in S phase, a subset of p53 target genes fails to be strongly induced despite the presence of high levels of p53. When DNA replication is inhibited, reduced p21 mRNA accumulation is correlated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ee339159ea01a553b207fc1553b8ca
https://europepmc.org/articles/PMC2701578/

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Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein

Autor: Jinwoo Ahn, Carol Prives, Masha V. Poyurovsky, Rachel Beckerman, Nicole Baptiste, Melissa Mattia, Jianmin Zhou, Andrew Zupnick, Christine Cain, Kristine McKinney, Vanesa Gottifredi

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scopus-Elsevier

Both sequence-specific DNA binding and exonuclease activities have been mapped to the central conserved core domain of p53. To gain more information about these two activities a series of mutants were generated that changed core domain histidine resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e741908264c2bb127a851ae26516e5
http://www.tandfonline.com/doi/abs/10.4161/cc.8.10.8548

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Energy-dependent nucleolar localization of p53 in vitro requires two discrete regions within the p53 carbonyl terminus

Autor: Kristine McKinney, Alan R. Fersht, Michael P. Sheetz, Rachel Beckerman, Andrew Zupnick, Orit Karni-Schmidt, Philippe Bouvet, Assaf Friedler, Melissa Mattia, Carol Prives

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2007, 26, pp.3878-3891. ⟨10.1038/sj.onc.1210162⟩
Oncogene, 2007, 26, pp.3878-3891. ⟨10.1038/sj.onc.1210162⟩

The p53 tumor suppressor is a nucleocytoplasmic shuttling protein that is found predominantly in the nucleus of cells. In addition to mutation, abnormal p53 cellular localization is one of the mechanisms that inactivate p53 function. To further under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7a4fabe5f83eabc959752d9b6fd7cf
https://hal.archives-ouvertes.fr/hal-00378604

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p53-Dependent p21 mRNA elongation is impaired when DNA replication is stalled

Autor: Melissa Mattia, Carol Prives, Vanesa Gottifredi, Kristine McKinney

We have previously reported that when DNA replication is blocked in some human cell lines, p53 is impaired in its ability to induce a subset of its key target genes, including p21(WAF1/CIP1). Here, we investigated the reason for this impairment by co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::264069d1befd744e965e97fbb6c32d8a
http://mcb.asm.org/content/27/4/1309

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p53 linear diffusion along DNA requires its C terminus

Autor: Carol Prives, Kristine McKinney, Melissa Mattia, Vanesa Gottifredi

Publikováno v: Molecular cell. 16(3)

In cells, sequence-specific transcription factors must search through an entire genome to find their target sites in promoters. Such sites may be identified by using one-dimensional (linear diffusion) and/or three-dimensional (association/dissociatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d609b7de5dd1a1ce079146fc281a2bfc
https://pubmed.ncbi.nlm.nih.gov/15525514

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