Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Melissa M. Singh"'
Autor:
Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients. Epigenetic alterations have been well documented in
Externí odkaz:
https://doaj.org/article/8cf1141c8fd94cffbd85efb1ee005dde
Autor:
Melissa M Singh, Adrienne Howard, Mary E Irwin, Yin Gao, Xiaolin Lu, Asha Multani, Joya Chandra
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51611 (2012)
The BCR-ABL1 oncogene is a tyrosine kinase that activates many signaling pathways, resulting in the induction of chronic myeloid leukemia (CML). Kinase inhibitors, such as imatinib, have been developed for the treatment of CML; however, the terminal,
Externí odkaz:
https://doaj.org/article/ed0cff22051b49f38527f7a4e0f4f26c
Autor:
Matthew C. Madison, Dev K. Chatterjee, David B. Corry, Ed Felix, Atul Varadhachary, John S. McMurray, Melissa M. Singh, Joel M. Sederstrom, Brandon Saxton, Pietro Morlacchi, Garbo Mak, Cameron T. Landers, Pijus K. Mandal, Brian E. Gilbert, J. Morgan Knight, Evan Li
Publikováno v:
Journal of Biological Chemistry. 293:10026-10040
Asthma is a chronic inflammatory disease of the lungs and airways and one of the most burdensome of all chronic maladies. Previous studies have established that expression of experimental and human asthma requires the IL-4/IL-13/IL-4 receptor α (IL-
Publikováno v:
ACS Chemical Neuroscience. 9:107-117
Selective targeting of drug loaded nanovectors to specific epitopes highly expressed on the surface of cancer cells is a goal for nanotechnologists. We have modified our previously described PEGylated-hydrophilic carbon clusters (PEG-HCCs) so that th
Autor:
Garrett L. Robinson, Aimee Iberg, Melissa M. Singh, Joseph D. Dekker, Hilario J. Ramos, Jay Zhao, Sara LeMar, Erin Willert
Publikováno v:
Cancer Research. 80:521-521
CD45 is highly expressed on the cell surface of all nucleated hematopoietic cells, including malignant cells of B, T and myeloid lineage. CD45, a receptor tyrosine phosphatase that has important roles in antigen receptor signaling, has multiple isofo
Autor:
Sara LeMar, Hilario J. Ramos, Garrett L. Robinson, Joseph D. Dekker, Aimee Iberg, Asis K. Sarkar, Banmeet Anand, Brigitte Brieschke, Melissa M. Singh, Jack P. Higgins, Jay Zhao, Erin Willert
Publikováno v:
Cancer Research. 80:3366-3366
Engineered toxin bodies (ETBs) comprised of a proprietarily engineered Shiga-like Toxin A subunit (SLTA) genetically fused to antibody-like binding domains work through novel mechanisms of action and can force internalization, self-route through intr
Autor:
Tiewei Cheng, Hayley Donnella, Mary E. Irwin, Melissa M. Singh, Nilsa Rivera-Del Valle, Joya Chandra
PURPOSE: Amongst the epigenetically-targeted therapies, targeting of the histone deacetylases (HDACs) has yielded numerous drugs for clinical use in hematological malignancies, but none as yet for acute lymphocytic leukemia (ALL). Single agent activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db78d13230e1dcdbfdd31b589d9e711c
https://europepmc.org/articles/PMC5837827/
https://europepmc.org/articles/PMC5837827/
Autor:
Frederick F. Lang, Elsa R. Flores, Avinashnarayan Venkatarayan, Jianping Zhang, Blake Johnson, Melissa M. Singh, Joya Chandra, Xiaoping Su, Michelle Craig Barton
Publikováno v:
Neuro-Oncology. 17:1463-1473
Background Glioblastoma (GBM) is the most common and aggressive form of brain cancer. Our previous studies demonstrated that combined inhibition of HDAC and KDM1A increases apoptotic cell death in vitro. However, whether this combination also increas
Autor:
Joya Chandra, Christa A. Manton, Blake Johnson, Cavan P. Bailey, Melissa M. Singh, Lisa Bouchier-Hayes
Publikováno v:
Scientific Reports
New therapies for glioblastoma (GBM) are needed, as five-year survival is in vivo properties of MRZ in GBM. The activation kinetics of initiator caspases 2, 8 and 9 were assessed using chemical and knockdown strategies to determine their contribution
Autor:
Mary E. Irwin, Joya Chandra, Yin Gao, Ping Shi, Hesham M. Amin, Melissa M. Singh, Kechen Ban, Ralph B. Arlinghaus
Publikováno v:
Cancer. 118:3433-3445
BACKGROUND: Patients with chronic myelogenous leukemia (CML) in blast crisis have a poor response to tyrosine kinase inhibitors designed to inhibit the breakpoint cluster region–v-Abelson murine leukemia viral oncogene homolog 1 (BCR-ABL1) oncogene