Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Melissa M. Heintz"'
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
HFPO-DA (ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate; CASRN 62037-80-3) is a component of the GenX technology platform used as a polymerization aid in the manufacture of some types of fluoropolymers. The liver is the primary target
Externí odkaz:
https://doaj.org/article/d689d5df4c3846ae9e1640cd9bf92500
Publikováno v:
Data in Brief, Vol 41, Iss , Pp 108013- (2022)
Cytochrome P450 2B6 (CYP2B6) is a human enzyme important in chemical detoxification, steroid and fatty acid metabolism that is primarily hepatic. Therefore, induction or inhibition of CYP2B6 may perturb endo- and xenobiotic metabolism and cause adver
Externí odkaz:
https://doaj.org/article/12de062068304dfeab0bf6c687867507
Autor:
Melissa M Heintz, Jazmine A Eccles, Emily M Olack, Kristal M Maner-Smith, Eric A Ortlund, William S Baldwin
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0277053 (2022)
Multiple factors in addition to over consumption lead to obesity and non-alcoholic fatty liver disease (NAFLD) in the United States and worldwide. CYP2B6 is the only human detoxification CYP whose loss is associated with obesity, and Cyp2b-null mice
Externí odkaz:
https://doaj.org/article/0503e917e1ce4e339c2b7eb665b32a7b
Publikováno v:
Journal of Lipids, Vol 2022 (2022)
Increases in traditional serum lipid profiles are associated with obesity, cancer, and cardiovascular disease. Recent lipidomic analysis has indicated changes in serum lipidome profiles, especially in regard to specific phosphatidylcholines, associat
Externí odkaz:
https://doaj.org/article/c25dd50b9a7a4058be8a42064267d301
Publikováno v:
Toxicological Sciences. 192:15-29
HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) is a short-chain polyfluorinated alkyl substance (PFAS) used in the manufacture of some types of fluorinated polymers. Like many PFAS, toxicity studies with HFPO-DA indicate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9607b33433b019341e35e8e516c2273
https://doi.org/10.1093/toxsci/kfad004
https://doi.org/10.1093/toxsci/kfad004
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229896 (2020)
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease; however, progression to nonalcoholic steatohepatitis (NASH) is associated with most adverse outcomes. CYP2B metabolizes multiple xeno- and endobiotics, and male Cyp2b-null mic
Externí odkaz:
https://doaj.org/article/77cbe9ee14f74ae6b3781f748d84f76d
Publikováno v:
Birth Defects Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4aae054ab7c98101ffdd75db2eba872
https://doi.org/10.1002/bdr2.2185
https://doi.org/10.1002/bdr2.2185
Publikováno v:
The American Biology Teacher. 84:202-206
What’s in Our Waters Jr. (WOW Jr.) is an environmental outreach program designed to teach fourth grade elementary students about watershed protection. This program is unique because of the partnership that brings together students, teachers, scient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bdc5f1cf6a3b14cda1fc4c7183cb019
https://doi.org/10.1525/abt.2022.84.4.202
https://doi.org/10.1525/abt.2022.84.4.202
Publikováno v:
Critical Reviews in Toxicology. 51:820-849
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2629f6115206910844eae8ea98e1f35
https://doi.org/10.1080/10408444.2021.2000934
https://doi.org/10.1080/10408444.2021.2000934
Autor:
Rayetta G. Henderson, Timothy W. Lefever, Melissa M. Heintz, Kristen R. Trexler, Susan J. Borghoff, Marcel O. Bonn-Miller
Publikováno v:
Food and Chemical Toxicology. 176:113778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0afc1aa6239d18e078ba461c4fd185b
https://doi.org/10.1016/j.fct.2023.113778
https://doi.org/10.1016/j.fct.2023.113778