Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Melissa M. Dix"'
Publikováno v:
mBio, Vol 6, Iss 4 (2015)
ABSTRACT Type I signal peptidase (SPase) is essential for viability in wild-type bacteria because the terminal step of the bacterial general secretory pathway requires its proteolytic activity to release proteins from their membrane-bound N-terminal
Externí odkaz:
https://doaj.org/article/08c0d951e2bf43b6b656e4227aded9c8
Autor:
Michael R. Lazear, Jarrett R. Remsberg, Martin G. Jaeger, Katherine Rothamel, Hsuan-lin Her, Kristen E. DeMeester, Evert Njomen, Simon J. Hogg, Jahan Rahman, Landon R. Whitby, Sang Joon Won, Michael A. Schafroth, Daisuke Ogasawara, Minoru Yokoyama, Garrett L. Lindsey, Haoxin Li, Jason Germain, Sabrina Barbas, Joan Vaughan, Thomas W. Hanigan, Vincent F. Vartabedian, Christopher J. Reinhardt, Melissa M. Dix, Seong Joo Koo, Inha Heo, John R. Teijaro, Gabriel M. Simon, Brahma Ghosh, Omar Abdel-Wahab, Kay Ahn, Alan Saghatelian, Bruno Melillo, Stuart L. Schreiber, Gene W. Yeo, Benjamin F. Cravatt
SummaryMost human proteins lack chemical probes, and several large-scale and generalizable small-molecule binding assays have been introduced to address this problem. How compounds discovered in such “binding-first” assays affect protein function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07f22999c7fd8b3058ebc700cdfeab3
https://doi.org/10.1101/2022.12.12.520090
https://doi.org/10.1101/2022.12.12.520090
Autor:
Chieh Chen, Brett Lomenick, Min Chai, Wilson Huang, Jessie Chu, Laurent Vergnes, Reid O’Brien Johnson, Ajay A. Vashisht, Randall M. Chin, Melissa M. Dix, Gabriel Simon, Xudong Fu, Jenny C. Link, Heejun Hwang, Xiang Yin, Stéphanie C. de Barros, Daniel Braas, Nahn Hee Diane Kim, Yibin Wang, Steven M. Dubinett, Michael A. Teitell, Oliver Fiehn, Meisheng Jiang, Benjamin F. Cravatt, James A. Wohlschlegel, Joseph A. Loo, Karen Reue, Jing Huang
Aging is a complex process that is directly related to human health and disease. The extraordinary finding that aging is malleable, as shown in model organisms whose life and health spans are extended by specific gene mutations or dietary or pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c4778bd35323664c7ac99f97892f9
https://doi.org/10.1101/2022.10.10.511641
https://doi.org/10.1101/2022.10.10.511641
Autor:
Amanda Long, Anagha Inguva, Marina Predovic, Jarrett R. Remsberg, Thomas W. Hanigan, Stewart K. Richardson, Noemi A. Zambetti, Micah J. Niphakis, Nhi Ngo, Amy R. Howell, Cassandra L. Henry, Ari J. Firestone, Benjamin F. Cravatt, Kenneth M. Lum, Ben Huang, Kevin Shannon, Radu M. Suciu, Melissa M. Dix
Publikováno v:
Nature chemical biology, vol 17, iss 8
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b253176c07cc9e4d8c9643b76bcc8a6
https://doi.org/10.1038/s41589-021-00785-8
https://doi.org/10.1038/s41589-021-00785-8
Autor:
Kristen A. Baltgalvis, Vincent M. Crowley, Michael A. Schafroth, Brian E. Nordin, Benjamin F. Cravatt, Christie L Eissler, Joe L Rodriguez, Shota Kikuchi, Xiaoyu Zhang, Thomas G Wucherpfennig, Todd Kinsella, Kent T Symons, Melissa M. Dix, David S. Weinstein, Dean Stamos, Gabriel M. Simon, Yu Yamashita, Ludwig Bauer, Lena M Luukkonen
Publikováno v:
J Am Chem Soc
Ligand-induced protein degradation has emerged as a compelling approach to promote the targeted elimination of proteins from cells by directing these proteins to the ubiquitin-proteasome machinery. So far, only a limited number of E3 ligases have bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9801b3a3bafd3e374259ca9ad1a1524
https://doi.org/10.1021/jacs.1c00990
https://doi.org/10.1021/jacs.1c00990
Publikováno v:
Tetrahedron Lett
Non-small-cell lung cancer (NSCLC) is a major disease that accounts for 85% of all lung cancer cases which claimed around 1.8 billion lives worldwide in 2020. Tyrosine kinase inhibitors (TKIs) that target EGFR have been used for the treatment of NSCL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::893c1374d954dc8260ffa4b9c3f85e6d
https://pubmed.ncbi.nlm.nih.gov/34764521
https://pubmed.ncbi.nlm.nih.gov/34764521
Autor:
Laura L. Kiessling, Radu M. Suciu, Madeline E. Kavanagh, Yongfeng Tao, Benjamin F. Cravatt, Michael R. Lazear, Taka-Aki Ichu, Matthew Merrill Hayward, Vincent M. Crowley, Mikail E. Abbasov, Melissa M. Dix, Jordan Ho, Stephan M. Hacker, Christopher W. am Ende
Publikováno v:
Nat Chem
Recent advances in chemical proteomics have begun to characterize the reactivity and ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic electrophiles have been evaluated for interactions with the lysine proteome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f78bea59a5068219806c4dd51496f4d
https://europepmc.org/articles/PMC8952960/
https://europepmc.org/articles/PMC8952960/
Publikováno v:
Nature methods. 19(3)
Proteomics has revealed that the ~20,000 human genes engender a far greater number of proteins, or proteoforms, that are diversified in large part by post-translational modifications (PTMs). How such PTMs affect protein structure and function is an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f94df497414ac127b5ceaac8ae41a237
https://pubmed.ncbi.nlm.nih.gov/35228728
https://pubmed.ncbi.nlm.nih.gov/35228728
Autor:
Gregory D. Vite, Melissa M. Dix, Benjamin F. Cravatt, Jarrett R. Remsberg, Hsinyu Lee, Steven P. Gygi, Yujia Wang, Giulia Bianco, Christopher G. Parker, R. Michael Lawrence, Marian Kalocsay, Stefano Forli
Publikováno v:
Nature Chemistry. 11:1113-1123
A fundamental challenge in chemical biology and medicine is to understand and expand the fraction of the human proteome that can be targeted by small molecules. We recently described a strategy that integrates fragment-based ligand discovery with che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41e802a6fddce0163812e91663a43514
https://doi.org/10.1038/s41557-019-0351-5
https://doi.org/10.1038/s41557-019-0351-5
Autor:
Jie H Hu, Ted R. Kohler, Nathan Airhart, Sina A. Gharib, Zachary E. Potter, Benjamin F. Cravatt, Tomas Vaisar, David A. Dichek, Kate Fox, Jay W. Heinecke, Roberto F. Nicosia, Melissa M. Dix, Gabriel M. Simon
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown. Objective: By
Rationale: Plaque rupture is the proximate cause of most myocardial infarctions and many strokes. However, the molecular mechanisms that precipitate plaque rupture are unknown. Objective: By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c577fb3289b11f7c70d65b252bc96d
https://pubmed.ncbi.nlm.nih.gov/32762496
https://pubmed.ncbi.nlm.nih.gov/32762496