Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Melissa M. Clemens"'
Autor:
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3836-3846 (2021)
We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose
Externí odkaz:
https://doaj.org/article/4a3814ab452048b8af9da9c8afc86904
Autor:
Melissa M. Clemens, Joel H. Vazquez, Stefanie Kennon-McGill, Sandra S. McCullough, Laura P. James, Mitchell R. McGill
Publikováno v:
Liver Research, Vol 4, Iss 3, Pp 145-152 (2020)
Background and aim: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in the propagation of the hepatotoxicity is controversial. Early research revealed that macrophage inhibitors protect against APAP i
Externí odkaz:
https://doaj.org/article/58c6f21bf8b54812ba9fde44dcecdb1a
Autor:
Melissa M. Clemens, Victor M. Cardenas, Lori A. Fischbach, Ruiqi Cen, Eric R. Siegel, Hari Eswaran, Uwemedimbuk S. Ekanem, Anuradha Policherla, Heather L. Moody, Everett F. Magann, Gunnar Boysen
Publikováno v:
Tobacco Induced Diseases, Vol 17, Iss June (2019)
Introduction Public awareness of electronic nicotine delivery systems (ENDS) has increased over time, and the perception that ENDS offer a safer alternative to cigarettes may lead some pregnant women to use them to reduce cigarette smoking during pre
Externí odkaz:
https://doaj.org/article/44a94acab83e44f2abed9feff638c509
Autor:
Victor M. Cardenas, Ruiqi Cen, Melissa M. Clemens, Heather L. Moody, Uwemedimbuk S. Ekanem, Anuradha Policherla, Lori A. Fischbach, Hari Eswaran, Everett F. Magann, Robert R. Delongchamp, Gunnar Boysen
Publikováno v:
Tobacco Induced Diseases, Vol 17, Iss May (2019)
Introduction The 2016 US Surgeon General’s Report suggests that the use of electronic nicotine delivery systems (ENDS) is a fetal risk factor. However, no previous study has estimated their effect on adverse pregnancy outcomes. We assessed the prev
Externí odkaz:
https://doaj.org/article/44923d69515448349de4fc2872f1b863
Publikováno v:
Hear Res
Inner ear drug delivery is a major area of research and development, but relatively little is known about basic drug metabolism in the cochlea. Additionally, the use of potentially ototoxic drugs such as NSAIDs, chemotherapeutics and aminoglycosides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7626e510b436a289859a74b91f055c6f
https://doi.org/10.1016/j.heares.2019.05.002
https://doi.org/10.1016/j.heares.2019.05.002
Autor:
Eric U. Yee, Brian N. Finck, Donald J. Johann, Melissa M. Clemens, Erich A. Peterson, Mitchell R. McGill, Felicia D. Allard, Laura P. James, Sandra S. McCullough, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3836-3846 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3836-3846 (2021)
We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9554adccdd3dcaab71263f1caf737cd8
https://pubmed.ncbi.nlm.nih.gov/35024310
https://pubmed.ncbi.nlm.nih.gov/35024310
Autor:
Brian N. Finck, Hartmut Jaeschke, Mitchell R. McGill, Stefanie Kennon-McGill, Laura P. James, George G. Schweitzer, Melissa M. Clemens, Andrew J. Lutkewitte
Publikováno v:
Food and Chemical Toxicology. 115:273-283
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ffbbea04c0dac054c41f35196e4e040
https://doi.org/10.1016/j.fct.2018.03.014
https://doi.org/10.1016/j.fct.2018.03.014
Autor:
Eric U. Yee, Joel H. Vazquez, Samuel G. Mackintosh, Mitchell R. McGill, Stefanie Kennon-McGill, Melissa M. Clemens, Michael D. Hambuchen, Felicia D. Allard, Hartmut Jaeschke
Publikováno v:
Toxicol Sci
The standard circulating biomarker of liver injury in both clinical settings and drug safety testing is alanine aminotransferase (ALT). However, ALT elevations sometimes lack specificity for tissue damage. To identify novel serum biomarkers with grea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ece382576a9ffa3468b3343ed50e90b
https://europepmc.org/articles/PMC8445655/
https://europepmc.org/articles/PMC8445655/
Autor:
Uwemedimbuk Smart Ekanem, Lori A. Fischbach, Everett F. Magann, Melissa M. Clemens, Eric R. Siegel, Hari Eswaran, Heather L. Moody, Gunnar Boysen, Victor M. Cardenas, Ruiqi Cen, Anuradha Policherla
Publikováno v:
Tobacco Induced Diseases
Tobacco Induced Diseases, Vol 17, Iss June (2019)
Tobacco Induced Diseases, Vol 17, Iss June (2019)
Introduction Public awareness of electronic nicotine delivery systems (ENDS) has increased over time, and the perception that ENDS offer a safer alternative to cigarettes may lead some pregnant women to use them to reduce cigarette smoking during pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b388358500afe5e964ce165d682757da
http://europepmc.org/articles/PMC6662780
http://europepmc.org/articles/PMC6662780
Autor:
Stefanie Kennon-McGill, Udayan Apte, Brian N. Finck, Melissa M. Clemens, Laura P. James, Mitchell R. McGill
Repair mechanisms after acetaminophen (APAP) hepatotoxicity are poorly understood. We recently discovered that phosphatidic acid (PA) increases in mice and humans after APAP overdose, and is critical for liver regeneration. Here, we hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6329715b14800efeb015ef959c7422ac
https://europepmc.org/articles/PMC6443093/
https://europepmc.org/articles/PMC6443093/