Výsledky vyhledávání - "Melissa M Mangala"

Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization

Autor: Melissa M Mangala, Timothy Y M Ng, Jamie I. Vandenberg, Matthew D. Perry, Adam D Hines, Whitney Liang, Chai Ann Ng, Michelle J O Xu, Adam P. Hill

Publikováno v: Cardiovascular Research. 116:1434-1445

Aims Current treatment for congenital long QT syndrome Type 2 (cLQTS2), an electrical disorder that increases the risk of life-threatening cardiac arrhythmias, is aimed at reducing the incidence of arrhythmia triggers (beta-blockers) or terminating t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7844f9ef082b403fbce3e7d313a1cbac
https://doi.org/10.1093/cvr/cvz247

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Comprehensive preclinical evaluation of how cardiac safety profiles of potential COVID-19 drugs are modified by disease associated factors

Autor: Stewart Heitmann, Jamie VaAndenberg, Nicholas Kerr, Monique J. Windley, Matthew D. Perry, Melissa M Mangala, Adam P. Hill, Jeffrey R. McArthur, Clifford TeBay

Background and Purpose: Hydroxychloroquine and chloroquine, alone or in combination with azithromycin, have been proposed as therapies for COVID-19. However, there is currently scant and inconsistent data regarding their proarrhythmic potential in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bda90ee0a593764c99e6e159daacbe5
https://doi.org/10.22541/au.161429217.72966648/v1

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Co-expression of calcium channels and delayed rectifier potassium channels protects the heart from proarrhythmic events

Autor: Jamie I. Vandenberg, Melissa M Mangala, Jesse Gillis, Adam P. Hill, Perry, Sara Ballouz, Stewart Heitmann

Cardiac electrical activity is controlled by the carefully orchestrated activity of more than a dozen different ion conductances. Yet, there is considerable variability in cardiac ion channel expression levels both within and between subjects. In thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c12d9b849b6ac97ca11370abfee598dd
https://doi.org/10.1101/659821

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Development of induced pluripotent stem cells from a patient with hypertrophic cardiomyopathy who carries the pathogenic myosin heavy chain 7 mutation p.Arg403Gln

Autor: Henrietta Cserne Szappanos, Samantha Barratt Ross, Christopher Semsarian, Melissa M Mangala, Adam P. Hill, Livia C. Hool, Mira Holliday, Seakcheng Lim

Publikováno v: Stem Cell Research, Vol 33, Iss, Pp 269-273 (2018)

Hypertrophic cardiomyopathy (HCM) is an inherited cardiomyopathy characterized by left ventricular hypertrophy ≥15 mm in the absence of loading conditions. HCM has a prevalence of up to one in 200, and can result in significant adverse outcomes inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca7fc347b33a82ef3d58ff016f70887
https://pubmed.ncbi.nlm.nih.gov/30508693

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