Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Melissa M, McGovern"'
Autor:
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves
Publikováno v:
eLife, Vol 11 (2022)
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss. ATOH1 expression in the developing cochlea can efficiently induce hair cell regeneration
Externí odkaz:
https://doaj.org/article/4cbcd933e07d46508ec37fe3ede0949c
Autor:
Melissa M. McGovern, Andrew K. Groves
Publikováno v:
Hair Cell Regeneration ISBN: 9783031206603
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d67ca37a788224cc2708eed8abdc628a
https://doi.org/10.1007/978-3-031-20661-0_5
https://doi.org/10.1007/978-3-031-20661-0_5
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
During embryonic development, differentiation of cochlear progenitor cells into hair cells (HCs) or supporting cells (SCs) is partially controlled through Notch signaling. Many studies have shown that inhibition of Notch signaling allows SCs to conve
Externí odkaz:
https://doaj.org/article/390e2dc31f2847cca857632e00e4cc44
Autor:
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fb899682977eaa33a98d9bf44af4bb7
https://doi.org/10.7554/elife.79712.sa2
https://doi.org/10.7554/elife.79712.sa2
Autor:
Teng-Wei Huang, Amrita A. Iyer, Melissa M. McGovern, Jeanne M. Manalo, Kevin K. Ohlemiller, Navish A. Bosquez Huerta, Heinrich Schrewe, Benjamin Deneen, Junsung Woo, Andrew K. Groves, Fredrick A. Pereira
Publikováno v:
J Neurosci
The Journal of Neuroscience
The Journal of Neuroscience
Mediator protein complex subunit 12 (Med12) is a core component of the basal transcriptional apparatus and plays a critical role in the development of many tissues. Mutations in Med12 are associated with X-linked intellectual disability syndromes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00e34f75e25fc41192fee652cc170cf
https://doi.org/10.1523/jneurosci.0070-21.2021
https://doi.org/10.1523/jneurosci.0070-21.2021
Autor:
Melissa M, McGovern, Byron, Hartman, Ankita, Thawani, Helen, Maunsell, Hongyuan, Zhang, Rizwan, Yousaf, Stefan, Heller, Jennifer, Stone, Andrew K, Groves
Publikováno v:
Hearing research. 428
The mammalian inner ear contains six sensory patches that allow detection of auditory stimuli as well as movement and balance. Much research has focused on the organ of Corti, the sensory organ of the cochlea that detects sound. Unfortunately, these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37a3967e0ca689639e3812ad1a48b6f0
https://pubmed.ncbi.nlm.nih.gov/36587458
https://pubmed.ncbi.nlm.nih.gov/36587458
Autor:
Melissa M. McGovern, Byron Hartman, Ankita Thawani, Helen Maunsell, Hongyuan Zhang, Rizwan Yousaf, Stefan Heller, Jennifer Stone, Andrew K. Groves
Publikováno v:
Hearing Research. 428:108686
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2f0734bb46c22429db9f5f13caebc48
https://doi.org/10.1016/j.heares.2022.108686
https://doi.org/10.1016/j.heares.2022.108686
Autor:
Melissa M. McGovern, Juan Llamas, Ksenia Gnedeva, Welly Makmura, Matthew Barton, James F. Martin, Xizi Wang, Talon Trecek, Andrew K. Groves, Neil Segil, Tanner O. Monroe, Mark E. Warchol, Litao Tao
Publikováno v:
Proc Natl Acad Sci U S A
Precise control of organ growth and patterning is executed through a balanced regulation of progenitor self-renewal and differentiation. In the auditory sensory epithelium—the organ of Corti—progenitor cells exit the cell cycle in a coordinated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b30a996a1d46d5c8abf75eaecb5b75
https://pubmed.ncbi.nlm.nih.gov/32482884
https://pubmed.ncbi.nlm.nih.gov/32482884
Publikováno v:
Development (Cambridge, England). 146(4)
Supporting cells (SCs) are known to spontaneously regenerate hair cells (HCs) in the neonatal mouse cochlea, yet little is known about the relative contribution of distinct SC subtypes which differ in morphology and function. We have previously shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8104cf9ed3187bcc0f91d712888cb3b
https://pubmed.ncbi.nlm.nih.gov/30770379
https://pubmed.ncbi.nlm.nih.gov/30770379
Four CreER lines that are commonly used in the auditory field to label cochlear supporting cells (SCs) are expressed in multiple SC subtypes, with some lines also showing reporter expression in hair cells (HCs). We hypothesized that altering the tamo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3580bd6139b3305e45b980b1b544f9c1
https://europepmc.org/articles/PMC5352607/
https://europepmc.org/articles/PMC5352607/