Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures

Autor: Melissa Lo Monaco, Greet Merckx, Jessica Ratajczak, Pascal Gervois, Petra Hilkens, Peter Clegg, Annelies Bronckaers, Jean-Michel Vandeweerd, Ivo Lambrichts

Publikováno v: Stem Cells International, Vol 2018 (2018)

Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair. Moreover, stem cell-based therapies usin

Externí odkaz: https://doaj.org/article/395cd0a677224b58a20fcca2320df131

DSS1 restrains BRCA2’s engagement with dsDNA for homologous recombination, replication fork protection, and R-loop homeostasis

Autor: Yuxin Huang, Wenjing Li, Tzeh Foo, Jae-Hoon Ji, Bo Wu, Nozomi Tomimatsu, Qingming Fang, Boya Gao, Melissa Long, Jingfei Xu, Rouf Maqbool, Bipasha Mukherjee, Tengyang Ni, Salvador Alejo, Yuan He, Sandeep Burma, Li Lan, Bing Xia, Weixing Zhao

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract DSS1, essential for BRCA2-RAD51 dependent homologous recombination (HR), associates with the helical domain (HD) and OB fold 1 (OB1) of the BRCA2 DSS1/DNA-binding domain (DBD) which is frequently targeted by cancer-associated pathogenic vari

Externí odkaz: https://doaj.org/article/f3092df21106479a9c84ccc7612b0ff2

Chorioallantoic Membrane Assay as Model for Angiogenesis in Tissue Engineering: Focus on Stem Cells

Autor: Ivo Lambrichts, Melissa Lo Monaco, Greet Merckx, Ward De Spiegelaere, Annelies Bronckaers, Hanna Tay, Marc A. M. J. van Zandvoort

Publikováno v: Tissue Engineering-Part B: Reviews, 26(6), 519-539. Mary Ann Liebert Inc.
Merckx, G, Tay, H, Lo Monaco, M, Van Zandvoort, M, De Spiegelaere, W, Lambrichts, I & Bronckaers, A 2020, ' Chorioallantoic Membrane Assay as Model for Angiogenesis in Tissue Engineering : Focus on Stem Cells ', Tissue Engineering. Part B. Reviews, vol. 26, no. 6, pp. 519-539 . https://doi.org/10.1089/ten.teb.2020.0048

Tissue engineering aims to structurally and functionally regenerate damaged tissues, which requires the formation of new blood vessels that supply oxygen and nutrients by the process of angiogenesis. Stem cells are a promising tool in regenerative me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6ab8ddd3b0b4bc7d43bd29164412f3
https://doi.org/10.1089/ten.teb.2020.0048

Safety and Homing of Human Dental Pulp Stromal Cells in Head and Neck Cancer

Autor: Ivo Lambrichts, Annelies Bronckaers, Melissa Lo Monaco, Uwe Himmelreich, Esther Wolfs, Greet Merckx

Publikováno v: Stem cell reviews and reports. 17(5)

Background: Head and neck cancer (HNC) is one of the most common cancers, associated with a huge mortality and morbidity. In order to improve patient outcomes, more efficient and targeted therapies are essential. Bone marrow-derived mesenchymal strom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfd5a78fce90008f5953a8362e9c0c3a
https://pubmed.ncbi.nlm.nih.gov/33822326

Trigeminal schwannoma presenting with malocclusion: A case report and review of the literature

Autor: Melissa Lo Presti, Sandi Lam, Katie Stormes, Jeffrey S. Raskin, Daniel C. Chelius, Brandon Emilio Bertot, Andrew Jea

Publikováno v: Surgical Neurology International

Background: Trigeminal schwannomas are rare tumors of the trigeminal nerve. Depending on the location, from which they arise along the trigeminal nerve, these tumors can present with a variety of symptoms that include, but are not limited to, changes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f1d324db30ffa47af1db59b3986e4a
http://europepmc.org/articles/PMC7451153