Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Melissa L. Sykes"'
Autor:
Christopher JS. Hart, Andrew G. Riches, Snigdha Tiash, Rebecca Abraham, Keely Fayd’Herbe, Ellis Joch, Bilal Zulfiqar, Melissa L. Sykes, Vicky M. Avery, Jan Šlapeta, Sam Abraham, John H. Ryan, Tina S. Skinner-Adams
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 54-62 (2023)
Giardia duodenalis is the causative agent of the neglected diarrhoeal disease giardiasis. While often self-limiting, giardiasis is ubiquitous and impacts hundreds of millions of people annually. It is also a common gastro-intestinal disease of domest
Externí odkaz:
https://doaj.org/article/3fa7736589924458957c5c2cc3f0b335
Autor:
Amanda F. Francisco, Gong Chen, Wen Wang, Melissa L. Sykes, Fanny Escudié, Ivan Scandale, Francisco Olmo, David M. Shackleford, Bilal Zulfiqar, Jadel M. Kratz, Thao Pham, Jessica Saunders, Meiyu Hu, Vicky M. Avery, Susan A. Charman, John M. Kelly, Eric Chatelain
Publikováno v:
Frontiers in Tropical Diseases, Vol 4 (2023)
The repurposing of approved drugs is an appealing method to fast-track the development of novel therapies for neglected diseases. Amiodarone and dronedarone, two approved antiarrhythmic agents, have been reported to have potential for the management
Externí odkaz:
https://doaj.org/article/ef8763e0491744609722bd57eeca7461
Publikováno v:
Microorganisms, Vol 11, Iss 2, p 476 (2023)
Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The disease causes ~12,000 deaths annually and is one of the world’s 20 neglected tropical diseases, as defined by the World Health Organisation. The drug discove
Externí odkaz:
https://doaj.org/article/5e6ae74c032e48f0ae19c6ecfb2a89e2
Publikováno v:
Microorganisms, Vol 10, Iss 7, p 1287 (2022)
Chagas disease caused by the protozoan Trypanosoma cruzi is endemic to 21 countries in the Americas, effects approximately 6 million people and on average results in 12,000 deaths annually. Human African Trypanosomiasis (HAT) is caused by the Trypano
Externí odkaz:
https://doaj.org/article/c9eba067cf6a428696091151793d2dc6
Autor:
Sabine Fletcher, Leonardo Lucantoni, Melissa L. Sykes, Amy J. Jones, John P. Holleran, Kevin J. Saliba, Vicky M. Avery
Publikováno v:
Parasites & Vectors, Vol 9, Iss 1, Pp 1-13 (2016)
Abstract Background In the fight against malaria, the discovery of chemical compounds with a novel mode of action and/or chemistry distinct from currently used drugs is vital to counteract the parasite’s known ability to develop drug resistance. An
Externí odkaz:
https://doaj.org/article/62bf9a4e1dc84e1eb1c8f9ff9c11a61a
Autor:
Melissa L. Sykes, Vicky M. Avery
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 5, Iss 3, Pp 215-228 (2015)
We have developed a high content 384-well, image-based assay to estimate the effect of compound treatment on Trypanosoma cruzi amastigotes in 3T3 fibroblasts. In the same well, the effect of compound activity on host cells can also be determined, as
Externí odkaz:
https://doaj.org/article/6fd7cbce4087459eafd2fddf72211c03
Publikováno v:
Marine Drugs, Vol 11, Iss 10, Pp 4058-4082 (2013)
Marine natural products are a diverse, unique collection of compounds with immense therapeutic potential. This has resulted in these molecules being evaluated for a number of different disease indications including the neglected protozoan diseases, h
Externí odkaz:
https://doaj.org/article/22c5ca0003a24c69a374858e16190b10
Autor:
Bilal Zulfiqar, Amy J. Jones, Melissa L. Sykes, Todd B. Shelper, Rohan A. Davis, Vicky M. Avery
Publikováno v:
Molecules, Vol 22, Iss 10, p 1715 (2017)
Kinetoplastid parasites cause vector-borne parasitic diseases including leishmaniasis, human African trypanosomiasis (HAT) and Chagas disease. These Neglected Tropical Diseases (NTDs) impact on some of the world’s lowest socioeconomic communities.
Externí odkaz:
https://doaj.org/article/f6967332bf034c9e9544a561ab4b7ec8
Autor:
Melissa L. Sykes, Jonathan B. Baell, Marcel Kaiser, Eric Chatelain, Sarah R. Moawad, Danny Ganame, Jean-Robert Ioset, Vicky M. Avery
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 7, Iss 1 (2013)
Externí odkaz:
https://doaj.org/article/6d7685be77c14a0c94ca1dabffe6f57b
Autor:
Chee Wei Ang, Brendon M. Lee, Colin J. Jackson, Yuehong Wang, Scott G. Franzblau, Amanda F. Francisco, John M. Kelly, Paul V. Bernhardt, Lendl Tan, Nicholas P. West, Melissa L. Sykes, Alexandra O. Hinton, Raghu Bolisetti, Vicky M. Avery, Matthew A. Cooper, Mark A.T. Blaskovich
Publikováno v:
Journal of Medicinal Chemistry. 65:13125-13142
Tuberculosis remains one of the leading causes of death from a single infectious agent, surpassing both AIDS and malaria. In recent years, two bicyclic nitroimidazole drugs, delamanid and pretomanid have been approved to treat this airborne infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48815ad0d1eeea35672ca673f74e283c
https://doi.org/10.1021/acs.jmedchem.2c00972
https://doi.org/10.1021/acs.jmedchem.2c00972